Modern Trends in Human Leukemia VI New Results in Clinical and Biological Research Including Pediatric Oncology: Organized on behalf of the Deutsche Gesellschaft für Hämatologie und Onkologie. Wilsede, June 17–20, 1984 Wilsede Joint Meeting on Pediatric O

Organized on behalf of the Deutsche Gesellschaft für Hämatologie und Onkologie. Wilsede, June 17-20, 1984 Wilsede Joint Meeting on Pediatric Oncology III. Hamburg, June 21/22, 1984. Front Matter....Pages I-XXXII Front Matter....Pages XXIX-XXX Introduction for N. A. Mitchison....Pages 1-2 Repertoire Purging by Medium Concentration Self-Macromolecules is the Major Factor Determining Helper and Suppressor Repertoire Differences....Pages 3-6 Introduction for P.H. Duesberg....Pages 7-8 Are Activated Proto- onc Genes Cancer Genes?....Pages 9-27 Front Matter....Pages 29-29 Allogeneic Marrow Transplantation from HLA-Identical Siblings in the Acute Leukemias: Baltimore Experience....Pages 31-33 Monoclonal Antibodies and Immunotoxins in Bone Marrow Transplantation: Purging Marrow of ALL or GVHD Cells with Preservation of Stem Cells....Pages 34-38 Bone Marrow Transplantation for Acute Leukemia....Pages 39-41 T Cell Depletion of Donor Marrow for Prevention of Acute Graft-Versus-Host Disease....Pages 42-43 Long-Term Survivors of Adult Acute Nonlymphocytic Leukemia: Fact or Fiction?....Pages 44-47 Risk Groups in a Multicenter Pilot Study for Treatment of Acute Lymphoblastic and Acute Undifferentiated Leukemia in Adults....Pages 48-50 New Approaches to the Treatment of Chronic Myelogenous Leukemia....Pages 51-52 The Feasibility of Opal/High Dose Ara-C Treatment of Adult Acute Lymphoblastic Leukaemia....Pages 53-55 Treatment of Leukemia with Low Dose Ara-C: A Study of 159 Cases....Pages 56-59 Treatment of Acute Myeloid Leukemia and Myelodysplastic Syndrome by Low Dose Cytosine Arabinoside....Pages 60-62 The Results of High Risk Acute Lymphoblastic Leukemia and Non-Hodgkin’s Lymphoma Total Therapy....Pages 63-66 Adult Acute Lymphoblastic Leukaemia at University Hospital, Malaysia....Pages 67-69 The Epipodophyllotoxin VP16-213 in Combination Chemotherapy for Adults with Acute Nonlymphoblastic Leukaemia....Pages 70-74 Treatment of Acute Lymphoblastic Leukemia in Childhood: A Report for the ALL 77-02 Group....Pages 75-77 Recent Results from Total Therapy Study X for Standard and High Risk Acute Lymphoblastic Leukemia in Children: Recognition of New Clinical and Biologie Risk Features....Pages 78-81 Improved Treatment Results in Childhood Acute Myelogenous Leukemia: An Update of the German Cooperative Study AML-BFM-78....Pages 82-83 Front Matter....Pages 29-29 Clinical Experiences with a Modified BFM Protocol in Childhood Acute Lymphoblastic Leukemia....Pages 84-89 Mechanisms of Drug Resistance in Human Leukemia....Pages 90-95 Summary Overview of Clinical Session....Pages 96-101 Red Cell Transfusions for Polytransfused Patients....Pages 102-106 Gram-Negative Bacteraemia: New Therapeutic Possibilities with Anti-Endotoxin Antibodies....Pages 107-111 Empiric Antimicrobial Therapy in Cancer Patients....Pages 112-118 Prophylaxis of Infection in Granulocytopenic Patients....Pages 119-122 Are Granulocyte Transfusions Helpful in Treating and Preventing Infections?....Pages 123-131 Single Donor Platelet Transfusion....Pages 132-136 Advances in Parenteral Nutrition Support of Children with Neoplastic Diseases....Pages 137-142 Antiemetics in Cancer Chemotherapy....Pages 143-144 Chromosome Abnormalities in Malignant Lymphoma: Biologic and Clinical Correlations....Pages 145-149 Oncogenetic Aspects of Chronic Myelocytic Leukemia....Pages 150-153 Association Between the Philadelphia Chromosome and a Unique abl Transcript....Pages 154-158 Somatic N- ras Oncogene Activation in a Patient with Acute Myeloblastic Leukemia....Pages 159-162 Behavior of Human Leukemic Progenitor Populations in Long-Term Marrow Culture....Pages 163-167 Stromal Progenitor Cells in Bone Marrow of Patients with Aplastic Anemia....Pages 168-171 Dyserythropoiesis in Acute Lymphoblastic Leukemia of Childhood....Pages 172-173 Ultrastructural Analysis of Normal and Leukaemic Cells by the Immunogold Method and Monoclonal Antibodies....Pages 174-179 Immunocytochemical Labelling of Haematological Samples Using Monoclonal Antibodies....Pages 180-182 Front Matter....Pages 29-29 Myelolactoferrin Index (MLF) and Myelopoiesis During Bacterial Infections and Malignant Diseases....Pages 183-186 ß-Hexosaminidase Isoenzyme I: An Early Marker of Hematopoietic Malignancy....Pages 187-189 Analysis of Leukemic Cells with Monoclonal Antibodies in Acute Myelomonocytic Leukemia Suggests Abnormality at an Early Differentiation Stage in Certain Cases....Pages 190-193 Nonspecific Cross-Reacting Antigen as a Marker of Myelocytic Leukemias in Individual Stages of Myelocytic Cell Differentiation....Pages 194-196 Plasminogen Activator as a Prognostic Factor in Hematological Malignancies....Pages 197-199 Immune Status of Leukemia Patients....Pages 200-203 Differential Expression of a Glycoprotein (p15E-RT) of Retroviral Origin in Patients Suffering from Various Hematological Disorders....Pages 204-206 Discrimination of Leukemias, Lymphomas, and Non-Neoplastic Controls by Retroviral Serum Markers....Pages 207-214 Front Matter....Pages 215-215 Modulation of Gene Expression Through DNA-Binding Proteins: Is There a Regulatory Code?....Pages 217-223 Cellular Oncogenes as the Ancestors of Endocrine and Paracrine Growth Factors and Their Evolutionary Relic Status in Vertebrates....Pages 224-227 The Genes That Carcinogens Act Upon....Pages 228-252 Chromosome Alterations in Oncogenesis....Pages 253-260 Chromatin Structure of the Human c- myc Oncogene: Definition of Regulatory Regions and Changes in Burkitt’s Lymphomas....Pages 261-265 Identification of the Human Cellular myc Gene Product by Antibody Against the Bacterially Expressed Protein....Pages 266-268 Oncogenes of Avian Acute Leukemia Viruses are Subsets of Normal Cellular Genes....Pages 269-272 Structure and Function of ras and Blym Oncogenes....Pages 273-276 TLym 1, a Stage-Specific Transforming Gene Which Shares Homology to MHCI Genes and Encodes a Secreted Protein....Pages 277-279 The mil/raf and myc Oncogenes: Molecular Cloning and In Vitro Mutagenesis....Pages 280-283 Characterization of the Number of Carbohydrate Chains on the Avian Erythroblastosis Virus erb B Gene Product and Their Role in Transformation....Pages 284-289 Characterization of Hematopoietic Cells Transformed In Vitro by AEV-H, a v-erb B -Containing Avian Erythroblastosis Virus....Pages 290-297 Front Matter....Pages 215-215 Different Cellular Substrates of Abelson Leukemia Virus Transforming Protein Kinase in Murine Fibroblasts and Lymphocytes....Pages 298-301 Regulin, a Cytoskeleton-Associated Protein Affecting Phosphorylation-Dephosphorylation....Pages 302-305 Viruses as Tumor Initiators and Tumor Promoters....Pages 306-307 Endemic and Sporadic Cases of Epstein-Barr Virus-Positive Burkitt’s Lymphoma: Immunological Characterization of Derived Cell Lines....Pages 308-311 Herpesvirus HVMA: A New Representative in the Group of the EBV-like B-Lymphotropic Herpesviruses of Primates....Pages 312-313 Tumors Induced in Hairless Mice by DNA from Human Malignant Cells....Pages 314-316 The Human T-Cell Leukemia Virus Family, Adult T Cell Leukemia, and AIDS....Pages 317-325 Molecular Studies of Human T Cell Leukemia/Lymphotropic Retroviruses....Pages 326-330 The Molecular Biology of Human T Cell Leukemia Virus and its Roles in Leukemogenesis of Adult T Cell Leukemia....Pages 331-334 HTLV-I Antibodies Associated with Cutaneous T Cell Lymphoma in Denmark....Pages 335-337 Presence of Antibodies to the Human T-Cell Leukemia Virus HTLV I in German Patients with Symptoms of AIDS....Pages 338-341 Roles of HTLV-I p19 and Natural Antibody to HTLV-I in Host Immune Responses....Pages 342-344 Antibodies to Human T-Cell Leukemia Virus-Membrane Antigens in Macaques with Malignant Lymphoma....Pages 345-349 Front Matter....Pages 351-351 Normal Regulators of Growth and Differentiation and the Reversal of Malignancy in Leukemia....Pages 353-362 Self-Renewal of Haemopoietic Stem Cells: The Roles of the Environment, of Growth Factors and of the src Oncogene....Pages 363-371 Coordinated Expression of c- myc Gene and a Multigenic Set May Modulate the Malignant Phenotype in Human Haemopoietic Cell Lines....Pages 372-375 Proliferation In Vivo and In Vitro of Haemopoietic Progenitor Cells Induced by AF-1, a New ras -Containing Retrovirus....Pages 376-379 Cloning and Expression of the Gene for Murine Granulocyte-Macrophage Colony-Stimulating Factor....Pages 380-384 Partial Characterization of Murine Haematopoietic Cell Growth Factor mRNA....Pages 385-387 Molecular Cloning of cDNA for the Human Interleukin-2 Receptor....Pages 388-395 Front Matter....Pages 351-351 Purification of Normal Human T-Cell Growth Factor to Molecular Homogeneity....Pages 396-397 Purification to Apparent Homogeneity and Biochemical Characterization of Human Pluripotent Hematopoietic Colony-Stimulating Factor....Pages 398-401 Differentiation in Myelodysplastic, Myeloid Leukaemic and Normal Haemopoietic Cells: A New Approach Exploiting the Synergistic Interaction Between Differentiation Inducers and DNA Synthesis Inhibitors....Pages 402-408 Vitamin D: Myeloid Differentiation and Proliferation....Pages 409-417 Biological Activities of a Human Pluripotent Hemopoietic Colony-Stimulating Factor....Pages 418-422 A T Lymphocyte-Derived Differentiation-Inducing Factor for Myeloid Leukemia Cells: Purification and Characterization....Pages 423-425 A Model Scheme of Hematopoietic Cell Differentiation Based on Multiple Marker Analysis of Leukemia-Lymphomas: T Cell Lineage....Pages 426-429 Changes in Isoenzyme Patterns Expressed by the Erythroleukemia Cell Lines K-562 and HEL After Induction of Differentiation....Pages 430-432 B Cell Lineage: Part of the Differentiation Program of Human Pluripotent Stem Cells....Pages 433-435 Differentiation Capacity of Null-AL(L) Cells in Culture....Pages 436-440 Evidence of Sternberg-Reed Cells Being Derived from Activated Lymphocytes....Pages 441-444 Production and Characterization of Monoclonal Antibodies Against the Leukemic Cell Line K562....Pages 445-446 Front Matter....Pages 447-447 Lymphocyte and Lymphoma Receptors Utilized in Differentiation, in Homing, and in Lymphomagenesis....Pages 449-454 Quantitative Expression and Function of Differentiation Antigens on Normal and Malignant Lymphoid Cells....Pages 455-460 Development of B Cell Subpopulations in Humans and its Relevance to Malignancy....Pages 461-470 Genetic Determination of the Cytolytic T Lymphocyte Receptor Repertoire....Pages 471-476 Internal Activity of the Immune System and its Physiologie Significance....Pages 477-480 Antigen Presentation by Liposomes....Pages 481-485 Thymic Dendritic Cells Present Blood-Borne Antigens to Medullary Thymocytes In Vivo: A Possible Role in the Generation of the T-Cell Repertoire....Pages 486-491 Natural Defense and Chemical Carcinogenesis....Pages 492-498 Front Matter....Pages 447-447 Genes and Antigens Controlling Tumor Metastases....Pages 499-507 Killer Cells in Leukemia....Pages 508-510 Influence of Colchicine and Cytochalasin B on Pinocytosis, Phagocytosis, and Antibody-Dependent Cell-Mediated Cytotoxicity....Pages 511-513 In Vivo Studies with Covalent Conjugates of Cobra Venom Factor and Monoclonal Antibodies to Human Tumors....Pages 514-517 Back Matter....Pages 519-521 In June 1984 a total of 169 physicians, scientists and students assembled in the now familiar and much-loved lair in the Wilsede Luneberg Heath near Hamburg, Germany, for the sixth biennial conference on Modern Trends in Human Leukaemia. This meeting, conducted by Prof. Rolf Neth in his own inimitable style, has established itself as one ofthe major events in the all too crowded programme of international conferences on leukaemia, cancer and related topics. Some may ponder why, with its "rustic" setting - flies, equine deposits, and lack of easy exit -, Wilsede has such an irresistible and persistent lure for so many of the world's top practitioners ofleukaemia research? The an swer is, I suspect, a cocktail of Rolfs extraordinary charm, the pleasure of meeting friends and colleagues in a uniquely informal and relaxed atmo sphere and the special style of the proceedings themselves, which focus on the evaluation of ideas and hypotheses rather than the cataloguing of data Organized on behalf of the Deutsche Gesellschaft fur Hamatologie und Onkologie. Wilsede, June 17-20, 1984 Wilsede Joint Meeting on Pediatric Oncology III. Hamburg, June 21/22, 1984.