Modern Trends in Human Leukemia V: New Results in Clinical and Biological Research Including Pediatric Oncology (Haematology and Blood Transfusion Hämatologie und Bluttransfusion, 28)

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Front Matter....Pages I-XXIX Front Matter....Pages 1-2 Immunobiology of Lymphoid Malignancy....Pages 3-10 Bone Marrow Transplantation in Leukemia....Pages 11-15 Front Matter....Pages 17-17 Nucleotide Metabolism and Enzyme Inhibitors in Thymic Acute Lymphoblastic Leukaemia....Pages 19-23 Selective Killing of Leukemia Cells by Inhibition of TdT....Pages 24-27 Poly(A)-polymerase Levels in Leukemia....Pages 28-29 Short-term Therapy for Acute Myelogenous Leukaemia in Younger Patients....Pages 30-35 Multicentre Pilot Study for Therapy of Acute Lymphoblastic and Acute Undifferentiated Leukemia in Adults....Pages 36-40 The Treatment of Acute Myelogenous Leukemia in Children and Adults: VAPA Update....Pages 41-45 Improved Results in Treatment of Acute Myelogenous Leukemia in Children — Report of the German Cooperative AML Study BFM-78....Pages 46-50 Acute Myeloid Leukaemia in Childhood: Treatment in the United Kingdom....Pages 51-55 Interferon in Acute Myelogenous Leukaemia: A Preliminary Report....Pages 56-58 Human Interferon-Beta in the Treatment of Non-Hodgkin Lymphoma....Pages 59-61 Results of LSA 2 -L 2 Therapy in Children with High-Risk Acute Lymphoblastic Leukemia and Non-Hodgkin’s Lymphoma....Pages 62-66 Clinical and Epidemiological Observations on Acute Lymphoblastic Leukemia Subtypes at the Sheba Medical Center, Israel....Pages 67-69 The Clinical Pharmacology of Cytosine Arabinoside....Pages 70-75 Enhancement of the Cell-Mediated Lysis of Fresh Human Leukemia Cells by Cytostatic Drugs....Pages 76-77 Secretion of Plasminogen Activators by Human Myeloid Leukemic Cells: Modulation and Therapeutic Correlations....Pages 78-80 Bone Marrow Transplantation in West Germany in Patients with Leukemia....Pages 81-86 Cyclosporin A Following Matched and Mismatched Family Allogeneic Bone Marrow Transplants....Pages 87-89 Autologous Bone Marrow Transplantation in Acute Leukemia and Non-Hodgkin’s Lymphoma: A Phase I Study of 4-Hydroperoxycyclophosphamide (4HC) Incubation of Marrow prior to Cryopreservation....Pages 90-91 Front Matter....Pages 17-17 Serological Inhibition of Graft Versus Host Disease: Recent Results in 28 Patients with Leukemia....Pages 92-96 Graft-Versus-Host Disease: Immunobiological Aspects....Pages 97-101 T-Cell Phenotypes in Mixed Leukocyte Reactions and After Bone Marrow Transplantation: Are Ia-Antigen on T-Cells a Marker for GvH Reactions?....Pages 102-106 Monoclonal Antibody Therapy: “Model” Experiments with Toxin-Conjugated Antibodies in Mice and Rats....Pages 107-111 In Vitro Cytodestruction of Leukemic Cells in Human Bone Marrow Using a Cocktail of Monoclonal Antibodies....Pages 112-116 In Vitro Treatment with Monoclonal Antibody Prior to Autologous Bone Marrow Transplantation in Acute Lymphoblastic Leukemia....Pages 117-123 Immunological Classification of Acute Lymphatic Leukemia....Pages 124-125 Multimarker Analysis of Childhood Acute Lymphoblastic Leukemia (ALL): Heterogeneity of Cellular Phenotypes and Clinical Relevance of Immunological Defined ALL Subclasses....Pages 126-130 Morphological and Cytochemical Features of Adult T-Cell Lymphoma-Leukaemia....Pages 131-134 Activities and Specificities of N -Acetylneuraminyltransferases in Leukemic Cells....Pages 135-138 WT1: A Monoclonal Antibody Reactive with T-ALL but not with Other Leukemias....Pages 139-141 Dysfunctional Glucocorticoid Receptors in Acute Leukemia....Pages 142-145 Glucocorticoid-Induced Lysis of Various Subsets of Acute Lymphoblastic Leukemia....Pages 146-147 Epidemiology of HTLV-Associated Leukemia....Pages 148-155 Current Prospects for Clinical Care of Acute Leukemia....Pages 156-160 Front Matter....Pages 161-161 Viral Oncogenes and Cellular Prototypes....Pages 163-172 The Transforming Gene of Avian Acute Leukemia Virus MC29....Pages 173-177 Cellular onc Genes: Their Role as Progenitors of Viral onc Genes and Their Expression in Human Cells....Pages 178-185 The Biology of an Oncogene, Based Upon Studies on Neoplasia in Xiphophorus ....Pages 186-206 The Transforming Gene of Avian Myeloblastosis Virus (AMV): Nucleotide Sequence Analysis and Identification of Its Translational Product....Pages 207-213 Front Matter....Pages 161-161 DNA-Binding Ability of Transforming Proteins from Avian Erythroblastosis Virus and Mutant Avian Myelocytomatosis Virus, MC29, in Comparison with MC29 Wild Type....Pages 214-217 Lack of Expression of Cellular Homologues of Retroviral onc Genes in Bovine Tumors....Pages 218-221 Molecular Dissection of the Bovine Leukemia Virus Envelope Glycoprotein (BLV gp51) by a Monoclonal Antibody Study....Pages 222-226 Detection and Localization of a Phosphotyrosine-Containing onc Gene Product in Feline Tumor Cells....Pages 227-235 The Use of cDNA Cloning Techniques to Isolate Genes Activated in Tumour Cells....Pages 236-240 Cellular Transforming Genes in Cancer....Pages 241-246 The Human onc Gene c-myc : Structure, Expression, and Amplification in the Human Promyelocytic Leukemia Cell Line HL-60....Pages 247-254 Determination of Virulence Properties of Leukemia Viruses....Pages 255-260 Generation of Recombinant Murine Leukemia Viruses De Novo: An Alternative Model for Leukemogenesis....Pages 261-269 Expression of Retroviruses During Early Mouse Embryogenesis....Pages 270-274 Natural History of M-MSV Tumors in Mice Carrying Endogenized Moloney Leukemia Virus....Pages 275-279 Induction of Histiocytomas by Pristane Treatment of Mice Chronically Infected with Moloney Murine Leukemia Virus....Pages 280-281 Purification of a Reverse Transcriptase-like Protein from the Plasma of a Patient with Chronic Myelogenous Leukemia and Production of Monoclonal Antibodies....Pages 282-283 Detection of Group and Interspecies Reactivities in Mammalian C-Type Virus p30 Proteins and Corresponding Human Antigens....Pages 284-288 Papovaviruses and Human Tumors....Pages 289-292 Characterization of Proteins Induced by Herpesvirus saimiri : Comparative Immunoprecipitation and Analysis of Glycosylation....Pages 293-294 Structural Organization and Expression of the Epstein-Barr Virus Genome....Pages 295-296 Induction of Latent Epstein-Barr Virus Information by a Serum Factor....Pages 297-298 Thymic Nurse Cells and Radiation Leukemia Virus Induced Thymic Lymphomas in C57BL Mice....Pages 299-300 Construction and Characterization of Chromosomal DNA Libraries....Pages 301-310 Front Matter....Pages 161-161 Human T-Cell Leukemia-Lymphoma Virus (HTLV): A Progress Report....Pages 311-319 Early Events in the Suppression of Myeloid Leukemic Cells by Biological Regulators....Pages 320-326 Myeloid Leukemic Cell Differentiation Induced by Human Postendotoxin Serum and Vitamin Analogues....Pages 327-337 Effect of Colony-stimulating Factors on the Proteins Synthesized by Normal and Leukemic Myeloid Progenitor Cells....Pages 338-344 Molecular Properties of a Factor Inducing Differentiation in Murine Myelomonocytic Leukemic Cells....Pages 345-347 A Model Scheme for Human Hematopoietic Cell Differentiation as Determined by Multiple Markers of Leukemia-Lymphomas....Pages 348-350 Studies on the In Vitro Microenvironment in Man....Pages 351-354 Granulocyte-Macrophage Progenitor Cell Proliferation and Differentiation....Pages 355-357 Proliferation and Maturation of Hemopoietic Cells from Patients with Preleukemia and Aplastic Anemia in Agar and Diffusion Chamber Cultures....Pages 358-361 Persistent Deficiency of Myeloperoxidase and Lactoferrin in Granulopoietic Cells of Patients with Acute Leukemia....Pages 362-365 Studies on Normal B-Cells and Common Acute Lymphoblastic Leukemia Blast Cells Using a Colony Assay....Pages 366-368 Human Interleukin 2: Physiology, Biochemistry, and Pathophysiology in Lymphoblastic Leukemias and Immunodeficiency Syndromes....Pages 369-379 Studies of Myelopoiesis Using Monoclonal Antibodies and Variant Lines from the Promyeloid Cell Line HL60....Pages 380-383 Mechanisms for Induction of Differentiation in the Human Promyelocytic Cell Line HL-60....Pages 384-385 Differentiation of a Human Myeloid Cell Line (HL-60) Toward Granulocyte- and Macrophage-like Cells: Comparison of Cell Surface Antigen Expression....Pages 386-388 Transmission of Human T-Cell Leukemia Virus (HTLV) into Human Cord Blood T Cells....Pages 389-393 K 562 Cell Line in Plasma Clot Diffusion Chambers: Changes in Cell Surface Phenotype in Relationship to Culture Conditions....Pages 394-396 Antigen Expression on Normal and Leukaemic Erythroid Precursors....Pages 397-402 The Early Stage of Friend Virus Erythroleukemias: Mechanisms Underlying BPA-“independent” In Vitro Growth of BFU-E....Pages 403-406 Evidence for the Origin of Hodgkin and Sternberg-Reed Cells from a Newly Detected Small Cell Population....Pages 407-410 Front Matter....Pages 161-161 Hodgkin’s Disease Cell Lines: Characteristics and Biological Activities....Pages 411-417 Prelymphoma, Early Lymphoma, and Manifest Lymphoma in Immunosialadenitis (Sjögren’s Syndrome) — A Model of Lymphomagenesis....Pages 418-422 Front Matter....Pages 423-423 B-Cell Malignancies: Origin and Extent of Clonal Involvement....Pages 425-433 Transfection as an Approach to Understanding Membrane Glycoproteins....Pages 434-439 Structural and Functional Aspects of the T-Cell Differentiation Antigens T3, T6, and T8....Pages 440-446 Human Histocompatibility Antigens....Pages 447-453 Structure and Expression of Class I Genes of the Mouse Major Histocompatibility Complex....Pages 454-458 Presence of HTLV in a Subset of T Cells from an Infected Patient: Some Immunochemical Properties of the Infected Cells....Pages 459-461 Hybrids Between Human Cell Lines Belonging to Different Hematopoietic Pathways: Analysis of HLA and Myeloid Surface Antigens....Pages 462-465 Natural Killer Cells and Their Targets: Impact of Differentiation on Target Cell Susceptibility....Pages 466-469 Natural Cellular Defense Activities Against Tumors — Cytostasis and NK Activity....Pages 470-471 Structure and Function of the Transferrin Receptor — A Possible Role in the Recognition of Natural Killer Cells....Pages 472-474 NK and K Cells in Malignant Lymph Nodes....Pages 475-478 Contrasuppression, Class I Antigens, and Cancer Immunity....Pages 479-485 Inhibition of the Induction of Contrasuppression by Antisera Against Tumor-Associated Surface Antigens on Methylcholanthrene-induced Sarcomas....Pages 486-488 Dissection of a Unique Tumor-Specific Transplantation Antigen into Multiple Unique Independent Epitopes using Syngeneic T-Cell Lines....Pages 489-492 Detection of Antigen-(AKR MuLV gp70)-Specific Circulating Immune Complexes (CIC) in Mice with Lymphomas....Pages 493-497 Immunological Characterization of the Natural Antibodies to Human T-Cell Leukemia Virus in Human Sera....Pages 498-503 Front Matter....Pages 505-505 General Summary of the Meeting....Pages 507-513 Back Matter....Pages 515-518 Levy, 10 Po: General Summary of the Meeting 507 Subject Index 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 515 1 Also special Lecture for the Wilsede Joint Meeting on Pediatric Oncolo gy II 2 Were also presented in the Wilsede Joint Meeting on Pediatric Oncology II 3 Presented in the Wilsede Joint Meeting on Pediatric Oncology II xv Participants of the Meeting Anders, Fritz, Genetisches Institut der Universitaet, Heinrich-ButT-Ring 58-62,6300 Giessen, Federal Republic of Germany Bauer, Georg, Institut fuer Virologie im Zentrum fUr Hygiene, Hermann Herder-Strasse 11,7800 Freiburg, Federal Republic of Germany Bell, Richard, Medical Oncology University Hospital, 75 East Newton Street, Boston, MA 02062, USA Bernhard, Silke, Dahlem-Konferenzen, Wallotstrasse 19, 1000 Berlin 33, Federal Republic of Germany Bister, Klaus, Max-Planck-Institut fUr Molekulare Genetik, Ihnestrasse 63-73, 1000 Berlin 33, Federal Republic of Germany Blattner, William A., Family Studies Section, Environmental Epidemiology Branch, National Cancer Institute, Landow Building, Rm. 4C18, 7910 Woodmont Avenue, Bethesda, MD 20205, USA Boiron, Michel, Institut de Recherches sur les Leucemies et les Maladies du Sang, Universite Paris VII, Hopital Saint-Louis, 2 Place du Docteur-Four nier, 75475 Paris Cedex 10, France Boniver, Jacques, Institut de Pathologie B 23, Laboratoire d'Anatomie, Pathologique, 4000 Liege, Belgium Bornkamm, Georg W., Institut fuer Virologie im Zentrum fuer Hygiene, Hermann-Herder-Strasse 11,7800 Freiburg, Federal Republic of Germany Burgess, Antony W Organized on behalf of the Deutsche Gesellschaft für Hämatologie und Onkologie, Wilsede, June 21-23, 1982