Modern Photocatalytic Strategies in Natural Product Synthesis 120

This book presents recent reports of total syntheses involving a photocatalytic reaction as a key step in the methodology. Modern photocatalysis has proven its generality for the development and functionalization of native functionalities. To date, the field has found broad applications in diverse research areas, including the total synthesis of natural products. Among the selected examples presented in this book, it highlights how the photocatalytic process proceeds in a highly chemo-, regio-, and stereoselective manner, thereby allowing the rapid access to structurally complex architectures under light-driven conditions. Cover Progress in the Chemistry of Organic Natural Products: Volume 120 Modern Photocatalytic Strategies in Natural Product Synthesis Copyright About This Book Contents Contributors Modern Photocatalytic Strategies in Natural Product Synthesis 1. Introduction 1.1. Fundamentals of Photocatalysis 1.2. Photocatalysts Used in Total Syntheses—Experimental 2. Radical Cyclizations 2.1. Cyclizations of Carbon-Centered Radicals 2.1.1. Alkyl Halides as Radical Precursors 2.1.2. Carboxylic Acids and Derivatives as Radical Precursors 2.2. Cyclizations of Nitrogen-Centered Radicals 2.3. Other C–C and C–N Bond-Forming Cyclization Reactions 3. Cycloadditions 3.1. (2 + 2) Cycloadditions 3.1.1. (2 + 2) Cycloadditions via Energy Transfer (EnT) 3.1.2. (2 + 2) Cycloadditions via Photoinduced Electron Transfer 3.2. (4 + 2) Cycloadditions 3.3. (3 + 2) Cycloadditions 3.4. (2 + 2 + 2) Cycloadditions 4. Radical Intermolecular Additions 4.1. Additions of Carbon-Centered Radicals to Alkenes 4.2. Additions of Carbon-Centered Radicals to Arenes or Hetarenes 5. Miscellaneous 5.1. Carbon–Carbon Bond Fragmentations 5.2. Reductive Dehalogenation and Decarboxylation 5.3. Mesolytic Cleavage 5.4. Oxidative Dehydrogenation 6. Concluding Remarks References About the Authors