Modern organic synthesis in the laboratory : a collection of standard experimental procedures

Searching For Reaction In Organic Synthesis Has Been Made Much Easier In The Current Age Of Computer Databases. However, The Dilemma Now Is Which Procedure One Selects Among The Ocean Of Choices. Especially For Novices In The Laboratory, It Becomes A Daunting Task To Decide What Reaction Conditions To Experiment With First In Order To Have The Best Chance Of Success. This Collection Intends To Serve As An Older And Wiser Lab-mate One Could Have By Compiling Many Of The Most Commonly Used Experimental Procedures In Organic Synthesis. With Chapters That Cover Such Topics As Functional Group Manipulations, Oxidation, Reduction, And Carbon-carbon Bond Formation, Modern Organic Synthesis In The Laboratory Will Be Useful For Both Graduate Students And Professors In Organic Chemistry And Medicinal Chemists In The Pharmaceutical And Agrochemical Industries. 1. Fundamental Techniques; 2. Functional Group Manipulations; 3. Oxidation; 4. Reduction; 5. Carbon-carbon Bond Formation; 6. Protecting Groups. Jie Jack Li, Chris Limberakis, Derek A. Pflum. Includes Bibliographical References And Index. Contents......Page 14 Foreword......Page 8 Abbreviations and Acronyms......Page 16 1.1 Safety!......Page 24 1.2 Useful Preparations......Page 26 1.3 Chromatography......Page 38 1.4 Crystallization......Page 43 1.5 Residual Solvent Peaks in Nuclear Magnetic Resonance......Page 45 2.1 Alcohol Oxidation State......Page 49 2.2 Ketone Oxidation State......Page 60 2.3 Acid Oxidation State......Page 65 3.1 Alcohol to Ketone Oxidation State......Page 76 3.2 Alcohol to Acid Oxidation State......Page 89 3.3 Olefin to Diol......Page 91 3.4 Aldehyde to Acid Oxidation State......Page 97 3.5 Heteroatom Oxidations......Page 99 4.1 Alcohols to Alkanes......Page 102 4.2 Aldehydes, Amides, and Nitriles to Amines......Page 104 4.3 Carboxylic Acids and Derivatives to Alcohols......Page 106 4.4 Esters and Other Carboxylic Acid Derivatives to Aldehydes......Page 109 4.5 Ketones or Aldehydes to Alcohols......Page 112 4.6 Ketones to Alkanes or Alkenes......Page 119 4.7 Reductive Dehalogenations......Page 125 4.8 Carbon–Carbon Double and Triple Bond Reductions......Page 126 4.9 Heteroatom–Heteroatom Reductions......Page 129 5.1 Carbon–Carbon Forming Reactions (Single Bonds)......Page 132 5.2 Carbon–Carbon Double Bonds (Olefin Formation)......Page 171 5.3 Reactions that Form Multiple Carbon–Carbon Bonds......Page 187 6.1 Alcohols and Phenols......Page 189 6.2 Amines and Anilines......Page 197 6.3 Aldehydes and Ketones......Page 206 B......Page 212 C......Page 213 F......Page 214 L......Page 215 O......Page 216 R......Page 217 T......Page 218 Z......Page 219

Searching for reaction in organic synthesis has been made much easier in the current age of computer databases. However, the dilemma now is which procedure one selects among the ocean of choices. Especially for novices in the laboratory, it becomes a daunting task to decide what reaction conditions to experiment with first in order to have the best chance of success. This collection intends to serve as an "older and wiser lab-mate" one could have by compiling many of the most commonly used experimental procedures in organic synthesis. With chapters that cover such topics as functional group manipulations, oxidation, reduction, and carbon-carbon bond formation, Modern Organic Synthesis in the Laboratory will be useful for both graduate students and professors in organic chemistry and medicinal chemists in the pharmaceutical and agrochemical industries.