Modern Neurosurgery of Meningiomas and Pituitary Adenomas (Acta Neurochirurgica Supplement Book 65)

"Modem Neurosurgery of Meningiomas and Pituitary Adenomas" presents the state-of-the-art of neurosurgery for these two types of tumors. Following a classification of the pituitary adenomas according to pathology, molecular biological factors are presented and their effects evaluated as these aspects deepen our understanding of the growth and further expansion of these tumors. The diagnosis is made not only by a study of the hormonal status, but also by neuroradiology. A number of authors have devoted their efforts to the special problem groups such as the elderly patients and those with huge pituitary adenomas. Particular emphasis is of course placed on the surgical treatment, including transcranial and transphenoidal neurosurgery, but the use of medical treatment and irradiation must be discussed as well. The treatment of meningiomas has also been influenced by the molecular biology of hormone and growth factors. Therefore it is accorded extensive space in this volume. The prognostic significance of nuclear DNA content is discussed. Recent research with new diagnostic methods such as somatostatin scintigraphy, PET studies end progesterone receptor in tumor fragment spheroids is presented here. The treatment of these tumors, however, depends largely on their localization. For the neurosurgeon, the surgical treatment of meningiomas involving the cavernous sinus, meningiomas of the ventral Foramen of Monroe, meningiomas of the cerebello­ pontine angle and of the optic sheath is presented by prominent experienced leaders in this field. Front Matter....Pages I-VIII Current Pathological Classification of Pituitary Adenomas....Pages 1-3 Molecular Biological Research in Pituitary Adenomas from the Pathologists’ View....Pages 4-6 Molecular Biology of Growth-Hormone-Secreting Human Pituitary Tumours: Biochemical Consequences and Potential Clinical Significance....Pages 7-10 Surgical Results in Microadenomas....Pages 11-12 Management of Huge Pituitary Adenomas....Pages 13-15 The Role of Transcranial Surgery in the Management of Pituitary Adenoma....Pages 16-17 Proliferation Parameters for Pituitary Adenomas....Pages 18-21 Protein Kinase C and Growth Regulation of Pituitary Adenomas....Pages 22-26 MR Imaging of Residual Tumor Tissue After Transsphenoidal Surgery of Hormone-Inactive Pituitary Macroadenomas: A Prospective Study....Pages 27-30 Persistent and Recurrent Hypercortisolism After Transsphenoidal Surgery for Cushing’s Disease....Pages 31-34 Surgical Treatment of Pituitary Adenomas in Elderly Patients....Pages 35-36 Combined Surgery and Radiotherapy of Invasive Pituitary Adenomas — Problems of Radiogenic Encephalopathy....Pages 37-40 LINAC-Radiosurgery (LINAC-RS) in Pituitary Adenomas: Preliminary Results....Pages 41-43 Comparison of Thermoregulatory Characteristics of Patients with Intra- and Suprasellar Pituitary Adenomas....Pages 44-49 The Molecular Biology of Hormone and Growth Factor Receptors in Meningiomas....Pages 50-53 Hormonal Dependency of Cerebral Meningiomas....Pages 54-57 Surgical Treatment of Meningiomas Involving the Cavernous Sinus: Evolving Ideas Based on a Ten Year Experience....Pages 58-62 Meningiomas Involving the Parasellar Region....Pages 63-65 Atypical and Malignant Meningiomas: Evaluation of Different Radiological Criteria Based on CT and MRI....Pages 66-69 Prognostic Significance of Nuclear DNA Content in Human Meningiomas: A Prospective Study....Pages 70-72 Correlation Between Cytogenetic and Clinical Findings in 215 Human Meningiomas....Pages 73-76 Surgical Results of Spinal Meningiomas....Pages 77-81 Microsurgical Management of Ventral and Ventrolateral Foramen Magnum Meningiomas....Pages 82-85 Meningiomas of the Cerebellopontine Angle....Pages 86-91 Management of Petroclival Meningiomas: A Critical Analysis of Surgical Treatment....Pages 92-94 Symptomatology, Surgical Therapy and Postoperative Results of Sphenoorbital, Intraorbital-Intracanalicular and Optic Sheath Meningiomas....Pages 95-98 Factors Influencing Morbidity and Mortality After Cranial Meningioma Surgery — a Multivariate Analysis....Pages 99-101 Clinical Relevance of Somatostatin Receptor Scintigraphy in Patients with Skull Base Tumours....Pages 102-104 Progesterone Receptors in Tumor Fragment Spheroids of Human Meningiomas....Pages 105-107 PET-Study of Intracranial Meningiomas: Correlation with Histopathology, Cellularity and Proliferation Rate....Pages 108-111 Back Matter....Pages 112-115 This book presents todays level of knowledge about pituitary adenomas and meningiomas. Molecular biology has added significant new information to our understanding of these tumors which in turn affects the current treatment of these tumor types. Pituitary adenomas require meticulous study not only in the diagnosis, but also in the analysis of the right kind of therapy which includes surgery, radiosurgery and medical treatment. Great progress has also been achieved in research on the hormonal aspects of meningiomas. Clinical symptomatology and treatment of these tumors depend largely on the localization of these meningiomas. The special problems associated with meningiomas of the cavernous sinus differ greatly from those of ventral foramen magnum meningiomas or optic sheath meningiomas. Experts on these specialized localizations of meningiomas present their experience