Modern Hematology: Biology and Clinical Management 2nd ed (CONTEMPORARY HEMATOLOGY)

Now in its second edition, Modern Hematology: Biology and Clinical Management reflects the major advances in the understanding, diagnosis, and treatment of blood disorders. It describes the latest clinical and scientific developments as well as details targeted and molecular therapies. The book brings together facts, concepts, and protocols important for the practice of hematology. In 23 chapters, all major blood diseases are covered, as well as rare diseases that are of scientific interest. As in the previous edition, each chapter is illustrated by tables, figures, and a selection of color plates. Over the past few decades the powerful methods of statistical physics and Euclidean quantum field theory have moved closer together, with common tools based on the use of path integrals. The interpretation of Euclidean field theories as particular systems of statistical physics has opened up new avenues for understanding strongly coupled quantum systems or quantum field theories at zero or finite temperatures. Accordingly, the first chapters of this book contain a self-contained introduction to path integrals in Euclidean quantum mechanics and statistical mechanics. The resulting high-dimensional integrals can be estimated with the help of Monte Carlo simulations based on Markov processes. The most commonly used algorithms are presented in detail so as to prepare the reader for the use of high-performance computers as an “experimental” tool for this burgeoning field of theoretical physics. Several chapters are then devoted to an introduction to simple lattice field theories and a variety of spin systems with discrete and continuous spins, where the ubiquitous Ising model serves as an ideal guide for introducing the fascinating area of phase transitions. As an alternative to the lattice formulation of quantum field theories, variants of the flexible renormalization group methods are discussed in detail. Since, according to our present-day knowledge, all fundamental interactions in nature are described by gauge theories, the remaining chapters of the book deal with gauge theories without and with matter. This text is based on course-tested notes for graduate students and, as such, its style is essentially pedagogical, requiring only some basics of mathematics, statistical physics, and quantum field theory. Yet it also contains some more sophisticated conceptswhich may be useful to active researchers in the field. Each chapter ends with a number of problems – guiding the reader to a deeper understanding of some of the material presented in the main text – and, in most cases, also features some listings of short, useful computer programs. Offers A Concise Summary Of The Fundamentals Of Clinical Hematology And Recent Developments, Facts On Malignant And Benign Blood Diseases, Therapies, Controversies, And Angiostatic Drugs. Basic Biology Of Hemopoiesis / Reinhold Munker -- Molecular Biology And Cytokines / Reinhold Munker And Amanda Sun -- Supportive Care In Hematology / John Hiemenz And Reinhold Munker -- Transplantation Of Stem Cells From Bone Marrow, Peripheral Blood And The Umbilical Cord / Ronald Paquette And Reinhold Munker -- Anemias: General Considerations, Microcytic, And Megaloblastic Anemias / Reinhold Munker -- Hemolytic Anemias / Reinhold Munker ... [et Al.] -- Leukocytosis, Leukopenia, And Other Reactive Changes Of Myelopoiesis / Reinhold Munker -- The Myeloproliferative Syndromes / Ronald Paquette, Erhard Hiller, And Reinhold Munker. Acute Myelogenous Leukemias / Reinhold Munker -- Acute Lymphoblastic Leukemias / Reinhold Munker And Vishwas Sakhalkar -- Myelodysplastic Syndromes / Ronald Paquette And Reinhold Munker -- Aplastic Anemias / Ronald Paquette And Reinhold Munker -- Lymphocytosis, Lymphopenia, Lymphadenopathy, And Splenomegaly / Reinhold Munker -- Hodgkin's Lymphoma / Erhard Hiller And Reinhold Munker -- The Non-hodgkin's Lymphomas / Reinhold Munker ... [et Al.] -- Multiple Myeloma And Related Paraproteinemias / Jonathan Glass And Reinhold Munker -- Congenital And Acquired Immunodeficiencies / Vishwas Sakhalkar And Reinhold Munker. Infections Relevant To Hematology / Reinhold Munker -- Basic Principles Of Hemostasis / Erhard Hiller -- Bleeding Disorders / Erhard Hiller -- Thrombophilia, Thromboembolic Disease, And Antithrombic Therapy / Erhard Hiller -- Transfusion Medicine And Immunohematology / Grace C. Tenorio, Snehalata C. Gupte, And Reinhold Munker -- Storage Disorders In Hematology / Reinhold Munker. Edited By Reinhold Munker ... [et Al.] ; Foreword By H. Phillip Koeffler. Rev. Ed. Of: Modern Hematology / Reinhold Munker, Erhard Hiller, Ronald Paquette. C2000. Includes Bibliographical References And Index. Reinhold Munker and his distinguished colleagues have updated and expanded Modern Hematology: Biology and Clinical Management, now in its second edition, to reflect the major advances in the understanding, diagnosis, and treatment of blood disorders. Modern Hematology: Biology and Clinical Management, Second Edition describes the latest clinical and scientific developments, including molecular studies used to diagnose a variety of hematological disorders and guide their treatment. Targeted and molecular therapies are discussed in detail, including kinase inhibitors in myeloproliferative disorders and humanized monoclonal antibodies. The use of peripheral blood and umbilical cord blood stem cells for transplantation is described, as well as the rationale and indications for non-myeloablative transplantation, emphasizing the preferability of immunotherapy over cytotoxic chemotherapy Offers a concise summary of the fundamentals of clinical hematology. This book presents the essential clinical facts concerning malignant and nonmalignant blood diseases, detailing diagnostic methods, angiostatic drugs, various therapies, classifications, scientific controversies, and treatment recommendations