Mode of Action, Metabolism and Toxicology : Pesticide Chemistry: Human Welfare and the Environment

Pesticide Chemistry: Human Welfare and the Environment, Volume 3: Mode of Action, Metabolism and Toxicology covers the proceeding of the Fifth International Congress of Pesticide Chemistry. This book is organized into three parts that tackle relevant issues regarding the use of pesticide. The opening part tackles topics relevant to the biochemistry of pests and mode of action of pesticides, such as influence of chlorinated and parathyroid insecticide on cellular calcium regulatory mechanisms; behavioral and lethal actions of amidines on invertebrates; and insect chitin synthetase as biochemical probe for insecticidal compounds. The second part encompasses metabolism and degradation of pesticides and xenobiotics and includes topics on propesticides; selective toxicity conferred by activation; and comparative biochemistry of animal, plant, and microorganism oxidases. The last part covers the toxicology of pesticides and xenobiotics, including the role of biochemical studies in modern toxicological assessment of pesticides; neurophysiological and behavioral assessment of pesticide toxicity; and genetic toxicology applied to the assessment of mutagenic, carcinogenic, and teratogenic action of pesticides and related compounds. This book will be of great interest to chemists, biologists, botanists, and entomologists or professionals whose line of work involves the use of pesticides and who are concerned with pesticide side-effects to the users and the environment. Content: Some Other IUPAC Titles of Interest from Pergamon Press , Page ii Front Matter , Page iii Copyright , Page iv Organizing Committee , Page x PREFACE , Page xi , Junshi Miyamoto, Philip C. Kearney INFLUENCE OF CHLORINATED AND PYRETHROID INSECTICIDES ON CELLULAR CALCIUM REGULATORY MECHANISMS , Pages 3-13 , Fumio Matsumura BEHAVIORAL AND LETHAL ACTIONS OF AMIDINES ON INVERTEBRATES , Pages 15-24 , Robert M. Hollingworth, Albert E. Lund INSECT CHITIN SYNTHETASE AS A BIOCHEMICAL PROBE FOR INSECTICIDAL COMPOUNDS , Pages 25-32 , Ephraim Cohen, John E. Casida BIOSYNTHETIC PROCESSES OF ERGOSTEROL AS THE TARGET OF FUNGICIDES , Pages 33-41 , Toshiro Kato RESISTANCE TO PYRIMIDINE FUNGICIDES WHICH INHIBIT ERGOSTEROL BIOSYNTHESIS , Pages 43-49 , Maarten A. de Waard, Johan Dekker MOLECULAR CHARACTERIZATION OF THE TARGET SITE(S) FOR HERBICIDES WHICH AFFECT PHOTOSYNTHETIC ELECTRON TRANSPORT , Pages 51-58 , C.J. Arntzen, K.E. Steinback, W. Vermaas, I. Ohad TOXIC OXYGEN SPECIES AND HERBICIDE ACTION , Pages 59-66 , Alan D. Dodge DIAGNOSTIC TECHNIQUES FOR NERVE POISON MODE OF ACTION , Pages 67-68 , T.A. Miller PHARMACOKINETIC APPROACHES TO THE ACTION OF PYRETHROIDS IN INSECTS , Pages 69-74 , David M. Soderlund PYRETHROID- AND DDT-EVOKED RELEASE OF GABA FROM THE NERVOUS SYSTEM IN VITRO , Pages 75-78 , Russell A. Nicholson, Roger G. Wilson, Charles Potter, Malcolm H. Black MODE OF ACTION OF HERBICIDES THAT AFFECT CELL DIVISION , Pages 79-84 , F.D. Hess MODE OF ACTION AND MO CALCULATION OF TWO CLASSES OF HERBICIDES INTERACTING WITH THE REDUCING SIDE OF PHOTOSYSTEM II , Pages 85-90 , A. Trebst, W. Draber, W.T. Donner EVIDENCE FOR TWO DIFFERENT HERBICIDE BINDING PROTEINS AT THE REDUCING SIDE OF PHOTOSYSTEM II , Pages 91-96 , Walter Oettmeier, Klaus Masson, Carl Fedtke, Jörg Konze, Robert R. Schmidt MODE OF ACTION OF NITRODIPHENYLETHERS AFFECTING PIGMENTS AND MEMBRANE INTEGRITY , Pages 97-102 , R. Lambert, G. Sandmann, P. Böger SITE OF ACTION OF PYRETHROID INSECTICIDES IN NEURONAL MEMBRANES AS REVEALED BY THE KDR RESISTANCE FACTOR , Pages 103-107 , Michael P. Osborne, Anna Smallcombe NERVE MEMBRANE SODIUM CHANNELS AS THE MAJOR TARGET SITE OF PYRETHROIDS AND DDT , Pages 109-114 , Toshio Narahashi INTERACTION OF PYRETHROIDS AND DDT-LIKE COMPOUNDS WITH THE SODIUM CHANNELS IN THE NERVE MEMBRANE , Pages 115-121 , Joep van den Bercken, Henk P.M. Vijverberg MODE OF ACTION OF TRIDEMORPH AND RELATED COMPOUNDS , Pages 123-127 , A. Kerkenaar ERGOSTEROL BIOSYNTHESIS: A TARGET OF FUNGITOXIC ACTION , Pages 129-134 , H.D. Sisler, Rosemary C. Walsh, B.N. Ziogas KITAZIN P AND EDIFENPHOS, POSSIBLE INHIBITORS OF PHOSPHATIDYLCHOLINE BIOSYNTHESIS , Pages 135-140 , Osamu Kodama, Tadami Akatsuka SITE OF ACTION OF CARBOXAMIDES IN MITOCHONDRIAL COMPLEX II , Pages 141-146 , G.A. White, G.D. Thorn, B.A.C. Ackrell, E.B. Kearney, R.R. Ramsey, T.P. Singer MODE OF ACTION OF RICE BLAST PROTECTANT, PROBENAZOLE , Pages 147-152 , Yasuharu Sekizawa MODE OF ANTIFUNGAL ACTION OF A NEW FUNGICIDE, TOLCLOFOS-METHYL , Pages 153-157 , Toshiro Kato USE OF HETEROZYGOUS DIPLOID STRAINS OF ASPERGILLUS NIDULANS FOR THE RECOGNITION OF GENETICALLY ACTIVE PESTICIDES , Pages 159-164 , S.G. Georgopoulos METABOLISM OF A PHOSPHOROTHIOLATE FUNGICIDE IBP BY STRAINS OF PYRICULARIA ORYZAE WITH VARIED SENSITIVITY , Pages 165-170 , Yasuhiko Uesugi, Masako Katagiri CHARACTERIZATION OF A 32 KILODALTON HERBICIDE-BINDING POLYPEPTIDE , Pages 171-176 , H.Y. Nakatani, K. Satoh, K.E. Steinback, C.J. Arntzen BEHAVIOUR OF METRIBUZIN IN TOLERANT AND SUSCEPTIBLE SOYBEAN VARIETIES , Pages 177-182 , Carl Fedtke, Robert R. Schmidt EFFECT OF INSECTICIDE ROTATIONS ON EVOLUTION OF RESISTANCE , Pages 183-189 , George P. Georghiou, Angel Lagunes, Jack D. Baker THE BIOCHEMISTRY OF INSECTICIDE RESISTANCE IN THE PEACH-POTATO APHID, MYZUS PERSICAE , Pages 191-196 , Alan L. Devonshire, Graham D. Moores, Chiang Chia-liang THE PRESENCE OF TWO FORMS OF GLUTATHIONE S-TRANSFERASES WITH DISTINCT SUBSTRATE SPECIFICITY IN OP-RESISTANT AND -SUSCEPTIBLE HOUSEFLY STRAINS , Pages 197-202 , N. Motoyama, A. Hayashi, W.C. Dauterman CHANGED ACETYLCHOLINESTERASE AND RESISTANCE IN LEAF- AND PLANTHOPPERS , Pages 203-208 , Hiroshi Hama DISCOVERY AND DEVELOPMENT OF ANTIDOTES TO IMPROVE HERBICIDE SELECTIVITY , Pages 209-212 , Gerald R. Stephenson, Ferenc M. Pallos ON THE MODE OF ACTION OF EPTC AND ITS ANTIDOTES , Pages 213-218 , Ferenc Dutka, Tamás Kõmives INFLUENCE OF HERBICIDES AND ANTIDOTES ON THE GLUTATHIONE LEVELS OF MAIZE SEEDLINGS , Pages 219-224 , G.R. Stephenson, A. Ali, F.M. Ashton RAPID MULTILEVEL INTERACTIONS OF A THIOCARBAMATE HERBICIDE AND ITS PROTECTANT IN MAIZE CELL CULTURES , Pages 225-231 , G. Ezra, H.M. Flowers, J. Gressel EPTC INHIBITION OF GIBBERELLIN PRECURSOR BIOSYNTHESIS AND REVERSAL OF THE INHIBITION BY N, N-DIALLYL-2, 2-DICHLOROACETAMIDE , Pages 233-236 , Robert E. Wilkinson PROPESTICIDES: BIOACTIVATION IN PESTICIDE DESIGN AND TOXICOLOGICAL EVALUATION , Pages 239-246 , John E. Casida SELECTIVE TOXICITY CONFERRED BY ACTIVATION , Pages 247-254 , W.C. Dauterman COMPARATIVE BIOCHEMISTRY OF ANIMAL, PLANT, AND MICROORGANISM OXIDASES , Pages 255-262 , Tsuneo Omura, Nobuhiro Harada, Hidefumi Yoshioka BIOACTIVATION INVOLVING CHEMICALLY REACTIVE OXYGENATED CARBON , Pages 263-274 , David H. Hutson BIOACTIVATIONS INVOLVING HALOGEN-CONTAINING SUBSTITUENTS , Pages 275-278 , Norio Kurihara BIOACTIVATION INVOLVING NITROGEN-CONTAINING SUBSTITUENTS , Pages 279-286 , K. Tatsumi, H. Yamada, S. Kitamura METABOLISM AND DEGRADATION OF PESTICIDES AND XENOBIOTICS: BIOACTIVATIONS INVOLVING SULFUR-CONTAINING SUBSTITUENTS , Pages 287-294 , Ingolf Schuphan, John E. Casida MALONYLCYSTEINE CONJUGATES AS END-PRODUCTS OF GLUTATHIONE CONJUGATE METABOLISM IN PLANTS , Pages 295-300 , Gerald L. Lamoureux, Donald G. Rusness CONJUGATION REACTIONS OF PESTICIDE METABOLITES WITH LIPIDS IN ANIMALS , Pages 301-306 , David A. Schooley, Gary B. Quistad PYRETHROID DETOXIFICATION AND SYNERGISM IN INSECTS , Pages 307-310 , Isaac Ishaaya, John E. Casida PHOTODEGRADATION OF PESTICIDES IN SOLUTION: ISOMERIZATION, DEHALOGENATION AND ESTER CLEAVAGE REACTIONS OF THE PYRETHROID INSECTICIDES , Pages 311-316 , Luis O. Ruzo THERMAL DEGRADATION OF PESTICIDES AND XENOBIOTICS: FORMATION OF POLYCHLORINATED DIOXINS AND DIBENZOFURANS , Pages 317-322 , Christoffer Rappe, Stellan Marklund LIGHT-INDUCED TRANSFORMATIONS OF PESTICIDES ON SILICA GEL AS A MODEL SYSTEM FOR PHOTODEGRADATION ON SOIL , Pages 323-326 , H. Hulpke, R. Stegh, R. Wilmes ATMOSPHERIC REACTIONS OF PESTICIDES , Pages 327-332 , Donald G. Crosby ASSESSMENT OF ABIOTIC TRANSFORMATION , Pages 333-338 , S. Gäb, F. Korte, W. Merz, H.-J. Neu BEHAVIOR AND FATE OF PESTICIDES IN PADDY ECOSYSTEMS , Pages 339-344 , Yuh-Lin Chen HUMUS-BOUND RESIDUES OF PHENYLAMIDE HERBICIDES: THEIR NATURE, PERSISTENCE AND MONITORING , Pages 345-350 , R. Bartha, I.-S. You, A. Saxena ANAEROBIC MICROSITES IN SOILS AND THEIR POSSIBLE EFFECT ON PESTICIDE DEGRADATION , Pages 351-356 , K. Haider BOUND PESTICIDE RESIDUES IN PLANTS , Pages 357-362 , R. Huber, S. Otto THE CAPABILITIES OF FISH AND OTHER AQUATIC ORGANISMS FOR XENOBIOTIC METABOLISM , Pages 363-368 , Gary L. Foureman, John R. Bend THE FATE OF PESTICIDE PLANT METABOLITES IN VERTEBRATES , Pages 369-374 , John Harvey Jr. COMPARATIVE METABOLISM OF SULFAMETHAZINE [4-AMINO- N - (4,6-DIMETHYL-2-PYRIMIDINYL)BENZENESULFONAMIDE] IN THE RAT, CHICKEN, PIG AND SHEEP (Note a) , Pages 375-380 , G. Paulson, C. Struble, A. Mitchell THE USE OF NON-HUMAN PRIMATES AS MODELS FOR THE METABOLISM OF PESTICIDES AND XENOBIOTICS IN MAN , Pages 381-386 , David R. Hawkins ETHICAL CONSIDERATIONS INVOLVING STUDIES OF PESTICIDES AND OTHER XENOBIOTICS IN MAN , Pages 387-394 , Wayland J. Hayes Jr. METABOLISM STUDIES WITH LIVER HOMOGENATE, HEPATOCYTE SUSPENSION AND PERFUSED LIVER , Pages 395-400 , Tsutomu Nakatsugawa, Shuji Tsuda DEUTERATION AS A TOOL IN THE STUDY OF XENOBIOTIC METABOLISM , Pages 401-405 , J. Portig THE ROLE OF BIOCHEMICAL STUDIES IN MODERN TOXICOLOGICAL ASSESSMENT OF PESTICIDES , Pages 409-418 , W.N. Aldridge NEUROPHYSIOLOGICAL AND BEHAVIORAL ASSESSMENT OF PESTICIDE TOXICITY , Pages 419-424 , Alvin M. Revzin GENETIC TOXICOLOGY APPLIED TO ASSESSMENT OF MUTAGENIC, CARCINOGENIC AND TERATOGENIC ACTION OF PESTICIDES AND RELATED COMPOUNDS , Pages 425-431 , Iain F.H. Purchase ASSESSING PESTICIDE TOXICITY IN MAN AND CORRELATIONS WITH LABORATORY ANIMAL STUDIES , Pages 433-436 , John Doull AN ASSESSMENT OF THE HAZARD OF SYNTHETIC PYRETHROID INSECTICIDES TO FISH AND FISH HABITAT , Pages 437-450 , Nuzrat Yar Khan ABSORPTION AND TRANSPORT OF INSECTICIDES IN VERTEBRATES , Pages 451-456 , F.E. Guthrie, S.M. Ahdaya, P.V. Shah, B.P. Maliwal OXYGEN ACTIVATION AND LIPOPEROXIDATIVE MECHANISMS OF TOXICITY OF PESTICIDES AND OTHER XENOBIOTICS , Pages 457-462 , James S. Bus MECHANISTIC STUDIES ON THE INHIBITION OF CYTOCHROME P-450-MEDIATED MIXED FUNCTION OXIDATION , Pages 463-468 , C.F. Wilkinson, M. Murray, C. Marcus, C. Dubé CHROMATOGRAPHIC TRANSLOBULAR MIGRATION OF XENOBIOTICS , Pages 469-474 , Tsutomu Nakatsugawa, Shuji Tsuda, Wendy K. Sherman ORGANOCHLORINE PESTICIDES AND INHIBITION OF INTERCELLULAR COMMUNICATION AS THE MECHANISM FOR THEIR LIVER TUMOR PRODUCTION , Pages 475-478 , Gary M. Williams ASSESSMENT OF TERATOGENICITY OF ETHYLENETHIOUREA , Pages 479-484 , S. Teramoto, M. Kaneda, R. Suzuki, H. Aoyama, H. Kobayashi, Y. Shirasu TOXICOLOGY OF PYRETHROIDS , Pages 485-490 , W.N. Aldridge NEUROTOXIC ESTERASE: CHARACTERIZATION AND POTENTIAL FOR A PREDICTIVE SCREEN FOR EXPOSURE TO NEUROPATHIC ORGANOPHOSPHATES , Pages 491-495 , R.J. Richardson, B.R. Dudek METHODS FOR TESTING IMMUNE EFFECTS OF TOXIC CHEMICALS: EVALUATION OF THE IMMUNOTOXICITY OF VARIOUS PESTICIDES IN THE RAT , Pages 497-504 , J.G. Vos, E.I. Krajnc, P.K. Beekhof, M.J. van Logten FUNCTIONAL, MORPHOLOGIC AND BIOCHEMICAL CORRELATES OF PULMONARY TOXICITY OF PARAQUAT , Pages 505-510 , Lewis L. Smith LIMITED IN VIVO LIVER BIOASSAYS FOR IDENTIFYING LONG-TERM BIOLOGICAL EFFECTS , Pages 511-514 , Gary M. Williams INTERACTIONS BETWEEN PESTICIDES AND OTHER XENOBIOTICS IN THE KIDNEY , Pages 515-520 , Jerry B. Hook, Victoria C. Serbia DIETARY FACTORS AFFECTING PESTICIDE TOXICITY , Pages 521-525 , S.M. Charbonneau, I.C. Munro EFFECT OF PROTEIN MALNUTRITION ON THE TOXICITY OF PESTICIDES , Pages 527-529 , Fina Kaloyanova, Maria Tasheva MECHANISMS OF TOLERANCE TO ANTICHOLINESTERASE INSECTICIDE TOXICITY , Pages 531-536 , S.D. Murphy, L.G. Costa, B. Schwab CONSECUTIVE SYSTEM OF TESTS FOR ASSESSMENT OF THE EFFECTS OF CHEMICAL AGENTS IN THE AQUATIC ENVIRONMENT , Pages 537-544 , Dorothea M.M. Adema, Jan Kuiper, Arnbjørn O. Hanstveit, Hans H. Canton STANDARDIZATION OF TEST PROCEDURES AND SPECIES IN ECOTOXICITY ASSESSMENTS: AN ALGAL TEST TO OBSERVE THE PHOTOSYNTHETIC ACTIVITY OF PORPHYRA SP . USING RADIO ISOTOPE TECHNIQUES , Pages 545-549 , T. Yoshida, T. Maruyama, H. Kojima, H. Saito FATE AND BIOLOGICAL EFFECTS OF INSECTICIDES IN PONDS , Pages 551-556 , N.O. Crossland, K.E. Elgar AUTHOR INDEX TO VOLUME 3 , Pages 557-558 SUBJECT INDEX TO VOLUME 3 , Pages 559-569