MODa 9 – Advances in Model-Oriented Design and Analysis : Proceedings of the 9th International Workshop in Model-Oriented Design and Analysis Held in Bertinoro, Italy, June 14-18, 2010

The volume contains the proceedings of the 9th Workshop on Model-Oriented Design and Analysis. It offers leading and pioneering work on optimal experimental designs, both from a theoretical point of view and in respect of real applications. Scientists from Eastern and Western Europe, the US, Asia and Africa, are contributors to this volume. Designs for nonlinear models, for discriminating between models, for multivariate data and for applications to medicine are some of the primary topics covered. Front Matter....Pages i-xxv Impact of Stratified Randomization in Clinical Trials....Pages 1-8 The Non-Uniqueness of Some Designs for Discriminating Between Two Polynomial Models in One Variable....Pages 9-16 Covariate Adjusted Designs for Combining Efficiency, Ethics and Randomness in Normal Response Trials....Pages 17-24 Split-Plot and Robust Designs: Weighting and Optimization in the Multiple Response Case....Pages 25-32 An Improvement in the Lack-of-Fit Optimality of the (Absolutely) Continuous Uniform Design in Respect of Exact Designs....Pages 33-39 Optimal Allocation Proportion for a Two-Treatment Clinical Trial Having Correlated Binomial Responses....Pages 41-48 Sample Size Determination for Multivariate Performance Analysis with Complex Designs....Pages 49-55 Optimal Design for Compositional Data....Pages 57-64 Dose Finding Experiments: Responses of Mixed Type....Pages 65-72 Pharmacokinetic Studies Described by Stochastic Differential Equations: Optimal Design for Systems with Positive Trajectories....Pages 73-80 On Testing Hypotheses in Response-Adaptive Designs Targeting the Best Treatment....Pages 81-88 Towards Gaussian Process-based Optimization with Finite Time Horizon....Pages 89-96 Optimal Designs for Linear Logistic Test Models....Pages 97-104 A Class of Screening Designs Robust to Active Second-Order Effects....Pages 105-112 D-Optimal Design for a Five-Parameter Logistic Model....Pages 113-120 Sequential Barycentric Interpolation....Pages 121-128 Some Considerations on the Fisher Information in Nonlinear Mixed Effects Models....Pages 129-136 Designs with High Breakdown Point in Nonlinear Models....Pages 137-144 A Note on the Relationship between Two Approaches to Optimal Design under Correlation....Pages 145-148 The Role of the Nugget Term in the Gaussian Process Method....Pages 149-156 A Bonferroni-Adjusted Trend Testing Method for Excess over Highest Single Agent....Pages 157-164 Asymptotic Properties of Adaptive Penalized Optimal Designs over a Finite Space....Pages 165-172 Filling and D-optimal Designs for the Correlated Generalized Exponential Model....Pages 173-180 Designs for Dose Finding Studies on Safety and Efficacy....Pages 181-188 A Radial Scanning Statistic for Selecting Space-filling Designs in Computer Experiments....Pages 189-196 Optimal Designs for Two-Colour Microarray Experiments for Estimating Interactions....Pages 197-204 Discrimination Between Random and Fixed Effect Logistic Regression Models....Pages 205-212 Estimation and Optimal Designing under Latent Variable Models for Paired Comparisons Studies via a Multiplicative Algorithm....Pages 213-220 Pointwise Consistency of the Kriging Predictor with Known Mean and Covariance Functions....Pages 221-228 Information in a Two-stage Adaptive Optimal Design for Normal Random Variables having a One Parameter Exponential Mean Function....Pages 229-236 Back Matter....Pages 237-239