Mitochondrial Disorders in Neurology: Butterworth-Heinemann International Medical Reviews (Butterworth-Heinemann International Medical Reviews. Neurology, 14)

Looks at the results of the recent discovery that disorders of the mitochondria have a role to play in many neurological disorders such as muscular degenerative diseases and Parkinson's Disease. Part of the ''BIMR'' series, this volume discusses this emerging field Content: Butterworth-Heinemann International Medical Reviews , Page ii Front Matter , Page iii Copyright , Page iv Contributors , Pages vii-viii Preface , Pages ix-x , Anthony H.V. Schapira, Salvatore DiMauro 1 - The structural organization of the mitochondrial respiratory chain , Pages 1-30 , J.M. Cooper, J.B. Clark 2 - Mitochondrial DNA and the genetics of mitochondrial disease , Pages 31-48 , Eric A. Schon 3 - Mitochondrial myopathies: clinical features, investigation, treatment and genetic counselling , Pages 49-74 , S.R. Hammans, J.A. Morgan-Hughes 4 - Biochemical and molecular features of deficiencies of Complexes I, II and III , Pages 75-90 , A.H.V. Schapira, J.M. Cooper 5 - Cytochrome oxidase deficiency: progress and problems , Pages 91-115 , Salvatore DiMauro, Michio Hirano, Eduardo Bonilla, Carlos T. Moraes, Eric A. Schon 6 - Mitochondrial encephalomyopathies: lumping, splitting and melding , Pages 116-129 , Lewis P. Rowland 7 - Intermediary Metabolism , Pages 130-144 , Darryl C. De Vivo 8 - Human defects of β-oxidation: clinical and molecular aspects , Pages 145-165 , Stefano DiDonato 9 - The use of tissue culture in the diagnosis of mitochondrial disease , Pages 166-180 , Brian H. Robinson 10 - Leber's hereditary optic neuropathy , Pages 181-198 , A.E. Harding, M.G. Sweeney 11 - Recent advances in mitochondrial genetics , Pages 199-226 , John M. Shoffner, Douglas C. Wallace 12 - Mitochondrial dysfunction in neurodegenerative disorders and aging , Pages 227-244 , A.H.V. Schapira Index , Pages 245-254 Mitochondrial Disorders in Neurology provides an overview of mitochondrial diseases. This book discusses the effects of mitochondrial dysfunction based on the relevant biochemistry and molecular genetics. The abnormal muscle and mitochondrial morphology in a variety of clinical presentations from isolated ophthalmoplegia to severe encephalopathy are also elaborated. This text likewise deliberates Leber's hereditary optic neuropathy, neurodegenerative disorders, and respiratory chain defects. Other topics covered include mitochondrial DNA and the genetics of mitochondrial disease; cytochrome oxidase deficiency; use of tissue culture in the diagnosis of mitochondrial disease; and advances in mitochondrial genetics. This publication is a good source for clinicians and students concerned with the defective mitochondrial function.