Mitochondria in Liver Disease (Oxidative Stress and Disease Book 39)

" excellent, well-organized, and timely."-Lester Packer and Enrique Cardenas, University of Southern California, Los Angeles, from the Series PrefaceThe liver is a vital organ that is responsible for a wide range of functions, most of which are essential for survival. The multitude of functions the liver performs makes it vulnerable to a wide range Content: OVERVIEW OF MITOCHONDRIAMetabolism of Superoxide Radical and Hydrogen Peroxide in the MitochondriaH. Susana Marinho and Fernando AntunesEnergy-Redox Axis in Mitochondria: Interconnection of Energy-Transducing Capacity and Redox StatusZhigang Liu, Harsh Sancheti, Enrique Cadenas, and Fei YinSignal Transduction Pathways That Regulate Mitochondrial Gene ExpressionChien-Yu Chen, Jingyu Chen, Anketse Debebe, Yang Li, and Bangyan StilesTranscriptional Regulation of Mitochondrial Biogenesis and Quality ControlHagir B. Suliman and Claude A. PiantadosiMitochondria in Liver Disease: Regulation of Liver Mitochondrial Function by Hydrogen SulfideKatalin Modis, Zahra Karimi, and Rui WangImpact of Aging and Calorie Restriction on Liver MitochondriaJon J. Ramsey, Jose Alberto Lopez-Dominguez, and Kevork HagopianDrug Delivery to Mitochondria: A Promising Approach for the Treatment of Liver DiseaseBhuvaneshwar Vaidya, Samit Shah, and Vivek GuptaROLE OF MITOCHONDRIA IN LIVER DISEASESCentral Role of Mitochondria in Drug-Induced Liver InjuryLily Dara, Heather Johnson, and Neil KaplowitzRole of Autophagy and Mitophagy in Liver DiseasesBilon Khambu, Hao Zhang, and Xiao-Ming YinMitochondrial Dynamics, Mitophagy and Mitochondrial Spheroids in Drug-Induced Liver InjuryJessica A. Williams, Hong-Min Ni, and Wen-Xing DingBiomarkers of Mitochondrial Damage in the LiverMitchell R. McGill and Hartmut JaeschkeAlterations of Mitochondrial DNA in Liver DiseasesEric A. Schon and Bernard FromentyEpigenetic Modifications of Mitochondrial DNA in Liver Disease: Focus on Nonalcoholic Fatty Liver DiseaseSilvia Sookoian and Carlos J. PirolaEmerging Role of Mitochondrial Dynamics in Viral HepatitisSeong-Jun Kim, Gulam Syed, Sohail Mohammad, Mohsin Khan, and Aleem SiddiquiMitochondrial Dynamics and Liver MetabolismMaria Isabel Hernandez-Alvarez and Antonio ZorzanoRole of JNK in Lipotoxicity in the LiverSanda Win, Tin Aung Than, and Neil KaplowitzMitochondrial Function, Dysfunction, and Adaptation in the Liver during the Development of DiabetesAndras Franko, Martin Hrabe de Angelis, and Rudolf J. WiesnerMitochondrial Dynamics and Adaptation in Alcoholic Liver Disease and Nonalcoholic Fatty Liver DiseaseJerome Garcia, Ho Leung, Bradley Blackshire, Carl Decker, Christopher Kyaw, and Derick HanAcid Sphingomyelinase, Mitochondria, and Liver DiseasesCarmen Garcia-Ruiz and Jose C. Fernandez-ChecaRegulation of Liver Metabolism by Sirtuins: Emerging RolesEric S. Goetzman The book is separated into two sections, the first of which highlights the latest developments in mitochondrial research. It includes cutting-edge topics such as the regulation of mitochondrial respiration using hydrogen sulfide and the regulation of mitochondrial fusionfission via the endoplasmic reticulum. The second section reviews the most current research on the role of mitochondria in a wide range of liver diseases. It also addresses novel topics such as the importance of liver mitochondrial constituents as biomarkers of liver injury in plasma and as regulators of the immune system