Mitochondria and Longevity (Volume 340) (International Review of Cell and Molecular Biology, Volume 340)

Mitochondria and Longevity, Volume 340, the latest release in the International Review of Cell and Molecular Biology series reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics with this release focusing on topics such as Mitochondria metabolism and aging, Mitohormesis, Mitochondrial dynamics in the aging stem cell compartment, Mitochondrial proteostasis and aging, Mitochondrial DNA mutations and aging, Mitochondrial sirtuins, NAD+, NADH and aging, Mitophagy and aging, Mitochondria, calcium transport and aging. Publishes only invited review articles on selected topics in cell and molecular biology Authored by established and active cell and molecular biologists Drawn from international sources Offers a wide range of perspectives on specific subjects Front Cover International Review of Cell and Molecular Biology INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY INTERNATIONAL REVIEW OFCELL AND MOLECULAR BIOLOGY: Mitochondria and Longevity Contents CONTRIBUTORS One -- Mitochondrial Metabolism and Aging in Yeast 1. INTRODUCTION 2. THE TRICARBOXYLIC ACID CYCLE 3. TRICARBOXYLIC ACID CYCLE DYSFUNCTIONS AND AGING 4. IMPAIRED MITOCHONDRIAL PYRUVATE/ACETYL-COA METABOLISM AND AGING 5. MITOCHONDRIAL METABOLISM OF BRANCHED-CHAIN AMINO ACIDS AND AGING 6. THE OXIDATIVE PHOSPHORYLATION. 7. RESPIRATION, ROS PRODUCTION AND AGING: A COMPLEX INTERPLAY7.1 Complex I 7.2 Complex II 7.3 Complex III 7.4 Complex IV 7.5 F1FO ATPase 8. ROLE OF NAD+ METABOLISM IN MITOCHONDRIAL FUNCTIONALITY 9. NAD+ METABOLISM AND AGING 10. NAD+ IS A KEY MODULATOR OF PATHWAYS INVOLVED IN THE AGING PROCESS 11. CONCLUSIONS ACKNOWLEDGMENTS REFERENCES Two -- Mitohormesis, an Antiaging Paradigm 1. INTRODUCTION 2. MITONUCLEAR COMMUNICATION 3. MITOHORMESIS SIGNALING 3.1 Reactive Oxygen Species 3.2 Mitochondrial Ions and Metabolites 3.3 Proteotoxic Signals. 3.4 Mitochondria-Cytosol Stress Responses3.4.1 Translational Stress Response 3.4.2 Post-translational Stress Responses 3.5 Mitokines 4. MITOHORMESIS AND LIFESPAN 5. MITOHORMESIS AND HEALTHSPAN 6. CONCLUDING REMARKS AND FUTURE OUTLOOK REFERENCES Three -- Coordinating Mitochondrial Biology Through the Stress-Responsive Regulation of Mitochondrial Proteases 1. INTRODUCTION 1.1 Organization and Activity of the Mitochondrial Proteolytic Network 1.1.1 Processing Peptidases Facilitate Establishment of the Mitochondrial Proteome. 1.1.2 Mitochondrial Quality Control Proteases Regulate the Integrity and Function of the Mitochondrial Proteome1.1.3 Oligopeptidases Degrade Polypeptides Within Mitochondria 1.2 Mitochondrial Proteases Are Key Regulators of Organellar Quality Control 1.2.1 Mitochondrial Morphology Is Regulated by the Activity of Mitochondrial Proteases 1.2.2 Proteolytic Control of Mitophagy 1.3 Mitochondrial Proteases Link Mitochondrial Proteostasis to Apoptotic Signaling 1.4 Stress-Responsive Regulation of the Mitochondrial Proteolytic Network. 1.4.1 Mitochondrial Unfolded Protein Response-Dependent Regulation of Mitochondrial Proteostasis1.4.2 The Integrated Stress Response Coordinates Mitochondrial Proteostasis in Response to Diverse Insults 1.4.3 LON Is Also Transcriptionally Regulated by Other Stress-Responsive Signaling Pathways 1.4.4 Posttranslational Regulation of Mitochondrial Proteolytic Activity 1.5 Altered Mitochondrial Protease Activity in Aging and Disease 1.5.1 Mutations in Mitochondrial Proteases Are Genetically Linked to Diverse Neurodegenerative Disorders.