Microenvironmental Aspects of Immunity : Proceedings of the Fourth International Conference on Lymphatic Tissue and Germinal Centers in Immune Reactions Held in Dubrovnik, Yugoslavia, June 26–30, 1972

Front Matter....Pages i-xxxii Front Matter....Pages xxxiii-xxxiii Structural Correlates of Immune Microenvironment....Pages 1-4 Front Matter....Pages 5-5 Introduction: Microenvironments in the Lymphoid System....Pages 7-10 Differentiation of B Lymphocytes from Stem Cell Precursors....Pages 11-18 Hemopoietic Origin of B Cells in the Mouse....Pages 19-26 Lymphocyte Differentiation in the Chicken Embryo — Relationship to the Microenvironment....Pages 27-33 The Lymphoid Development of the Embryonic Chicken Thymus in Organ Culture....Pages 35-41 Colonizing Capacity of Lymphoid Cells Injected into Syngeneic Hosts....Pages 43-48 Differential Traffic Patterns of T and B Lymphocytes in Relation to Germinal Centre Development....Pages 49-53 Ecotaxis of B Cells in the Mouse....Pages 55-62 Homing of B-Lymphocytes to Follicles: Specific Retention of Immunologically Committed Cells....Pages 63-70 Antigenic Markers on Lymphoid Cells Varying in their Capacity to Recirculate....Pages 71-77 Thymus Cell Migration: 3 HTDR-Labeled and Theta-Positive Cells in Peripheral Lymphoid Tissues of Newborn Mice....Pages 79-85 Lymph Node Function and Lymphocyte Circulation in the Pig....Pages 87-93 Germinal Centers: A Microenvironment for the Production of Antibody Forming Cell Precursors?....Pages 95-100 Microenvironmental Aspects of Lymphatic Tissue: Summary....Pages 101-103 Front Matter....Pages 105-105 Introduction: Cell Cooperation in Antibody Production — A Perspective with Questions....Pages 107-111 Functional Heterogeneity of Thymus-Derived Lymphocytes....Pages 113-118 Some Cell Surface Properties of Thymus-Derived Lymphocytes in Bursectomized Chickens....Pages 119-124 Studies on the Influence of T Cells in Antibody Responses of Mice to SIII and DNP-Lysine-SIII....Pages 125-131 Induction of Anti-Hapten Antibody Responses Against Haptens Conjugated to Autologous and Heterologous Proteins....Pages 133-139 Front Matter....Pages 105-105 Contribution of B and T Lymphocytes to in Vitro Chicken Proliferative Spleen Cell Reactions to Antigens....Pages 141-148 Proliferation of Activated Thymocytes in Mixed Lymphocyte Reactions....Pages 149-156 Lymphoid Cell Interactions in Cell-Mediated Immunity....Pages 157-166 Appendix and Thymus Cell Synergism in the Direct and Indirect Plaque Forming Cell Response to Sheep Erythrocytes in the Rabbit....Pages 167-170 The Role of Soluble Factors in T-B Cell Collaboration....Pages 171-178 Studies on the Source and Action of the T-Cell Replacing Factor (TRF)....Pages 179-182 Thymus Extracts Induce Differentiation of Thymus Derived Cells....Pages 183-189 Interaction of Lymphatic Cells: Summary....Pages 191-193 Front Matter....Pages 195-195 Introduction: Antigen Recognizing and Processing Cells....Pages 197-202 Immunoglobulin Surface Determinants on Chicken Lymphoid Cells....Pages 203-208 Functional and Morphologic Characteristics of Complement Receptor Lymphocytes in Mice....Pages 209-215 Stimulation of Mouse Thymocytes by Syngeneic Spleen Cells in Mixed Lymphocyte Reactions....Pages 217-223 Differential Induction and Suppression of Direct and Indidirect PFC Responses to TNP Conjugated to Heterologous Erythrocytes....Pages 225-232 Reconstitution of Primary Response in Vitro by Defined Peritoneal Cells....Pages 233-238 Uptake and Degradation of a Synthetic Antigen by Mouse Macrophages Containing Different Levels of Lysosomal Enzymes....Pages 239-245 Direct Evidence for Plaque Formation by Macrophages....Pages 247-253 The Proportion of Lymphocytes Capable of Recognizing Strong Transplantation Antigens in Vivo....Pages 255-262 Recovery of the Immune Response after Depletion of Specific Cells....Pages 263-268 Early Appearance of Antigen-Binding Cells to Two Different Antigens during Fetal Lymphoid Development....Pages 269-275 Antigen Recognizing and Processing Cells: Summary....Pages 277-279 Front Matter....Pages 281-281 Introduction: Cellular Aspects of Immune Deficiency Diseases Involving B Cells....Pages 283-287 Enhancement of the Immune Response of Genetically Thymus-Less Mice by Different Cell Populations....Pages 289-294 Thymus Factors and Immunity: Enhancement of Immunologic Maturation by a Purified Calf Thymus Extract....Pages 295-300 Involution of the Thymus Dependent Lymphoid System....Pages 301-306 A Study on Human T Lymphocytes, their Function and Frequency in Some Diseases....Pages 307-314 Evidence of Two Functionally Distinct Lymphocyte Populations in Man....Pages 315-320 The Relation between Nutritional Deprivation and Immunity....Pages 321-326 Combined System Immunodeficiency with Digeorge Syndrome and Dissociation of PHA/MLC Responses....Pages 327-336 Transplantation of Haemopoietic Stem Cell (HSC) Concentrates for Treatment of Immune Deficiency Disease....Pages 337-342 Immunological and Clinical Effects of Transfer Factor in Anergic Subjects....Pages 343-350 Cellular Aspects of Immune Deficiency Diseases: Summary....Pages 351-353 Front Matter....Pages 355-355 Introduction: Different Types of Immunological Unresponsiveness....Pages 357-362 Mechanism of Antigen Binding to Receptor Antibody in B Cell Immunity and Tolerance in Vitro ....Pages 363-368 Characteristics of B Cell Tolerance Induced with T-Independent Polysaccharides....Pages 369-375 Cortisone Interfering with the Production of “T and B cells”....Pages 377-382 Immunosuppression of the Thymectomized Fetal Lamb and its Neonatal Reconstitution....Pages 383-389 Antigen Recognition and Localization in Res Blockaded Mice: Morphologic and Immunologic Studies....Pages 391-398 The Effect of Cyclophosphamide on the Primary Humoral Immune Response. The Immunological Priming....Pages 399-405 Germinal Center in Rat Lymphatic Tissues after the Administration of L-Asparaginase....Pages 407-410 Enhancement of Tumour Growth by Lymphoid Cells from Mice Treated with Antilymphocyte Globulin....Pages 411-417 Front Matter....Pages 355-355 Role of the Spleen in Immunologic Enhancement of Kidney Grafts in Rats....Pages 419-425 Tolerance in Ovum Fusion Derived Tetraparental Mouse Chimaeras....Pages 427-434 Role of IgG 1 in Immunological Enhancement — Facilitation....Pages 435-442 Lymphatic Tissue in Tolerance, Immunosuppression and Facilitation: Summary....Pages 443-446 Front Matter....Pages 447-447 Introduction: Immune Reactions to Neoplastic Disease....Pages 449-454 Foetal Liver Stem Cells Inhibition by Ehrlich Ascites Carcinoma....Pages 455-460 Suppressed Plaque and Rosette-Formation by Spleen Cells of Mice Injected with Tumor Extracts....Pages 461-468 Immunosuppressive Factors Associated with Tumors....Pages 469-475 Effect of Therapy and Tumour Stage on Cellular Immunity to Bladder Carcinoma....Pages 477-482 Phase Specific Surface Autoantigens on Membranes of Fetus and Tumors....Pages 483-490 B Cell, T Cell and Monocyte Origin of the Guinea Pig L 2 C Leukemia, Mouse Lymphomas and Human Leukemias and Lymphoblastic Cell Lines....Pages 491-498 Immunocytes and Leukemia Virus Infection: Effects on Bone Marrow and Thymus Cell Responses and Interactions....Pages 499-505 Influence of the Lymphatic System on Development of a Virus-Induced Tumor (Reticuloendotheliosis) in the Chicken....Pages 507-512 Immune Reactions of the Syngeneic Host after the Intradermal Injection of Tumor Cells and Microsomes....Pages 513-518 Enhancement of Metastases by L-Asparaginase in Allogeneic and Isogeneic Mouse Tumor Systems....Pages 519-525 Reaction of Lymphatic Tissue in Neoplastic Disease: Summary....Pages 527-530 Front Matter....Pages 531-531 Introduction: Interaction between B and T Lymphocytes in Delayed Hypersensitivity....Pages 533-537 Contact Sensitivity in the Pig....Pages 539-544 The Effect of Lymphatic Interruption and Immediate Vascularization on the Afferent Arc of Skin Graft Rejection....Pages 545-551 Homograft Sensitivity in the Mouse: The Periodic Redistribution of Sensitised Lymphoid Cells....Pages 553-559 Front Matter....Pages 531-531 The Onset and Time-Course of Delayed-Type Hypersensitivity in Rats....Pages 561-566 Adjuvants and in Vitro Antibody Production....Pages 567-571 Basophilic Leukocytes in Delayed-Type Hypersensitivity Reactions in Experimental Animals and Man....Pages 573-579 Antibody and Cell Requirements for Cytotoxicity by Non-Immune Effector Cells....Pages 581-588 The Induction of a Cellular Immune Reaction against Self-Antigens Present in the Thymus....Pages 589-595 Germinal Center Formation in Response to Skin Grafted across Weak and Strong Histocompatibility (H 2 ) Barrier....Pages 597-602 Thymectomy and Bursectomy in Chickens with Simultaneous Experimental and Spontaneous Autoimmune Disease....Pages 603-609 Possible Role of Lymphokines in the Development of Ectopic Lymphoid Foci in the Chicken....Pages 611-618 Mediators of Cellular Hypersensitivity and Immunity Including Immunologically Specific Factors....Pages 619-626 Lymphatic Tissue in Immunopathology, with Special Reference to Delayed Hypersensitivity: Summary....Pages 627-630 Front Matter....Pages 631-631 Introduction: New Experimental Approaches....Pages 633-636 Manipulation of Fertilised Mouse Eggs Applied to Immunology....Pages 637-641 The Use of Germ-Free Piglets in the Study of Lymphoid Tissue and Germinal Centre Formation....Pages 643-649 Influence of Thymus on the Development of Endocrine and Immune Functions in Ontogeny....Pages 651-654 Hormones and Lymphoid Tissues. Contact Sensitivity and Detection of Theta-Cells in Pituitary Dwarf Mice....Pages 655-660 Immune Response and Lymphatic Tissue Reaction in Brain-Lesioned Rats....Pages 661-666 Stress and Hormonal Intervention in the Graft-Versus-Host Response....Pages 667-674 Antibody Responses in Cell Cultures from Draining and Non-Draining Rabbit Lymph Nodes Primed with Native or Polymerized Human Albumin....Pages 675-682 Changes in DNA Synthesis During Immunization in Mouse Spleen as Shown by Autoradiographs with Long Exposure Times....Pages 683-691 The Specific Separation of Enzyme Antigen-Binding Cells by Substrate Affinity Chromatography....Pages 693-698 Front Matter....Pages 631-631 New Experimental Approaches: Summary....Pages 699-701 Front Matter....Pages 703-703 Molecular Pharmacology of Cell-Mediated Immunity....Pages 705-711 Immuno-Embryology....Pages 713-718 Back Matter....Pages 719-726