Micro- and Nano-Transport of Biomolecules

"This e-book introduces the reader to biomolecules and describes the experimental and theoretical aspects of their micro- and nano-scale motion in water. Particular emphasis is given to their transport in engineered micro-environments where they are driven by externally imposed electric fields. Envisaged application technologies of this wide-ranging science involve healthcare, food provisioning, environmental services, etc. The e-book is generally intended for undergraduate students studying chemical, life, physical and engineering sciences, and also interdisciplinary researchers." Content 1. Introduction 1.1. Motivation: biomolecules in scientific context 1.2. Length scale of transport 1.3. Biomolecule transport example: engineered microdevices 1.4. Structure of this e-book 2. Biomolecules and their electrical properties 2.1. Biomolecules in cells 2.2. Biomolecules: structure and function 2.3. Biomolecules: electrical properties 2.4. Concluding remarks 3. Moving biomolecules using electric fi elds 3.1. Electrophoresis 3.2. Dielectrophoresis (DEP) 3.3. Micro-environments for biomolecule transport 3.4. Concluding remarks 4. Basic micro- and nano-transport 4.1. Inertial, friction and sedimentation forces on single biomolecules 4.2. Electromagnetic forces acting on single biomolecules 4.3. Thermal fl uctuations 4.4. Combining forces for predicting single bioparticle trajectory 4.5. Langevin equation for a single bioparticle (biomolecule) 4.6. Langevin equation stochastic integration and the modifi ed diffusion equation (MDE) 4.7. Concluding remarks 5. Observing, quantifying and simulating electrically driven biomolecule microtransport 5.1. Micro-device and experimental arrangement 5.2. Observations and quantitative measurements 5.3. Simulations of electrically driven biomolecule micro-transport 5.4. Brief discussion of experiments and theory 5.5. Concluding remarks 6. References 6.1. General – selected books 6.2. Research articles and other reading Sisältö Introduction Motivation: biomolecules in scientific context Length scale of transport Biomolecule transport example: engineered microdevices Structure of this e-book Biomolecules and their electrical properties Biomolecules in cells Biomolecules: structure and function Biomolecules: electrical properties Concluding remarks Moving biomolecules using electric fi elds Electrophoresis Dielectrophoresis (DEP) Micro-environments for biomolecule transport Concluding remarks Basic micro- and nano-transport Inertial, friction and sedimentation forces on single biomolecules Electromagnetic forces acting on single biomolecules Thermal fl uctuations Combining forces for predicting single bioparticle trajectory Langevin equation for a single bioparticle (biomolecule) Langevin equation stochastic integration and the modifi ed diffusion equation (MDE) Concluding remarks Observing, quantifying and simulating electrically driven biomolecule microtransport Micro-device and experimental arrangement Observations and quantitative measurements Simulations of electrically driven biomolecule micro-transport Brief discussion of experiments and theory Concluding remarks References General – selected books Research articles and other reading Obsah Introduction Motivation: biomolecules in scientific context Length scale of transport Biomolecule transport example: engineered microdevices Structure of this e-book Biomolecules and their electrical properties Biomolecules in cells Biomolecules: structure and function Biomolecules: electrical properties Concluding remarks Moving biomolecules using electric fi elds Electrophoresis Dielectrophoresis (DEP) Micro-environments for biomolecule transport Concluding remarks Basic micro- and nano-transport Inertial, friction and sedimentation forces on single biomolecules Electromagnetic forces acting on single biomolecules Thermal fl uctuations Combining forces for predicting single bioparticle trajectory Langevin equation for a single bioparticle (biomolecule) Langevin equation stochastic integration and the modifi ed diffusion equation (MDE) Concluding remarks Observing, quantifying and simulating electrically driven biomolecule microtransport Micro-device and experimental arrangement Observations and quantitative measurements Simulations of electrically driven biomolecule micro-transport Brief discussion of experiments and theory Concluding remarks References General – selected books Research articles and other reading This e-book introduces the reader to biomolecules and describes the experimental and theoretical aspects of their micro- and nano-scale motion in water. Particular emphasis is given to their transport in engineered micro-environments where they are driven by externally imposed electric fields. You can download the book for free via the link below.