Metastasis of Colorectal Cancer (Cancer Metastasis - Biology and Treatment Book 14)

Colorectal cancer is the third most common cancer worldwide, and in many parts of the western world, it is the second leading cause of cancer-related deaths. This book covers colon cancer metastasis from the most fundamental aspects to clinical practice. Major topics include physiopathology, genetic and epigenetic controls, cancer initiating cells, epithelial-mesenchymal transition, growth factors and signalling, cell adhesion, natures of liver metastasis, angiogenesis and lymphangiogenesis, inflammatory response, prognostic markers, sentinel node and staging, and finally diagnosis and treatment. Each chapter has been contributed by leaders in the field. A key feature is that it connects with a large readership including students, fundamentalists and clinicians. Another specific feature of the book is that the chapters are written in a didactic and illustrative fashion. These characteristics coupled with the choice of the topics and authors, makes this book a reference in the field. It represents an essential acquisition for medical libraries, clinicians as well as medical and graduate students. Front Matter....Pages i-xvi The Metastatic Process: An Overview....Pages 1-31 Physiopathology of Colorectal Metastasis....Pages 33-64 The Genetics of Colorectal Cancer....Pages 65-100 Epigenetics of Colorectal Cancer....Pages 101-125 Cancer-Initiating Cells in Colorectal Cancer....Pages 127-146 Epithelial-Mesenchymal Transition in Colorectal Cancer....Pages 147-172 Cell Adhesion Molecules in Colon Cancer Metastasis....Pages 173-203 Epithelial Cell Signalling in Colorectal Cancer Metastasis....Pages 205-241 Angiogenesis and Lymphangiogenesis in Colon Cancer Metastasis....Pages 243-287 Role of the Host Inflammatory Response in Colon Carcinoma Initiation, Progression and Liver Metastasis....Pages 289-319 Molecular Prognostic Markers in Colon Cancer....Pages 321-341 The Sentinel Lymph Node and Staging of Colorectal Cancer....Pages 343-358 Treatment of Colorectal Cancer....Pages 359-388 Diagnosis and Treatment of Rectal Cancer....Pages 389-407 Future Directions....Pages 409-411 Back Matter....Pages 413-416