Metastasis of Breast Cancer (Cancer Metastasis - Biology and Treatment Book 11)

Metastasis (spread of cancer in the body) is the main cause of death for patients with breast cancer, the leading female tumour in the industrialised countries and developing countries alike. The biology and treatment of breast cancer metastasis remains an active area of scientific and clinical investigation. Written by experts in the subject area, the book has covered a broad range of topics in the metastasis of breast cancer, from genetics, biology to clinical management. Main topics include genetic control, biology, growth factors, cell adhesion, cell motility and invasion, natures of bone metastasis, sentinel node therapies, hormonal links, new biomarkers and detection of micrometastasis, and diagnosis The book also covers the current treatment options including surgical management, chemotherapy and hormonal therapies. This timely book provides the current knowledge in the area of breast cancer metastasis and will be of important reading material for oncologists, radiologists, cancer researchers, biologists and health worker. Front Matter....Pages i-xiv Metastasis of breast cancer: an introduction....Pages 1-5 The genetic control of breast cancer metastasis....Pages 7-30 BRCA1 in initiation, invasion, and metastasis of breast cancer: a perspective from the tumor microenvironment....Pages 31-46 Cell motility and breast cancer metastasis....Pages 47-75 Tight junctions and metastasis of breast cancer....Pages 77-110 Cell adhesion molecules in breast cancer invasion and metastasis....Pages 111-136 Endocrine resistance and breast cancer invasion....Pages 137-150 The role of aromatase and other oestrogen producing enzymes in mammary carcinogenesis....Pages 151-170 The role of the HGF regulatory factors in breast cancer....Pages 171-202 The insulin-like growth factor-1 ligand in breast cancer management....Pages 203-217 Lymphangiogenesis and metastatic spread of breast cancer....Pages 219-240 Breast cancer secreted factors alter the bone microenvironment....Pages 241-258 Cyclooxygenease-2 and breast cancer....Pages 259-277 Prognostic and predictive factors in human breast cancer....Pages 279-305 Molecular imaging in metastatic breast cancer....Pages 307-319 Detection of disseminated tumor cells in the bone marrow and blood of breast cancer patients....Pages 321-331 Sentinel lymph node biopsy in early-stage breast cancer....Pages 333-353 Surgical management of patients with metastatic breast cancer....Pages 355-372 Therapeutic aspect of metastatic breast cancer: chemotherapy....Pages 373-388 The diagnosis and treatment of bone metastases in breast cancer....Pages 389-403 Hormonal therapies of metastatic breast cancer: the past and the present....Pages 405-423 Back Matter....Pages 425-435 Written by experts in the subject area, the book covers a broad range of topics in the metastasis of breast cancer, from genetics, biology to clinical management. Main topics include genetic control, biology, growth factors, cell adhesion, cell motility and invasion, natures of bone metastasis, sentinel node therapies, hormonal links, new biomarkers and detection of micrometastasis and diagnosis. This timely book also covers the current treatment options. Edited By Robert E. Mansel, Oystein Fodstad, And Wen G. Jiang. Includes Bibliographical References And Index.