Metals in Bone : Proceedings of a EULEP Symposium on the Deposition, Retention and Effects of Radioactive and Stable Metals in Bone and Bone Marrow Tissues, October 11th – 13th 1984, Angers, France

In 1980 the Internal Emitters Committee of EULEP organised a symposium in Rotterdam on Bone and Bone Seeking Radionu cI ides: Their Physiology, Dosimetry and Effects. The speakers for this meeting, mostly from EULEP associ­ ated laboratories, were chosen to review this field of scientific research mostly for the benefit of interested scientists who were not actively researching with bone­ seeking radionuclides. This meeting was a success and its proceedings were subsequently published in the form of a book by the Commission of the European Communities, reflecting the great importance that both EULEP and the Radiologi­ cal Protection Programme of the Commission of the European Communities attaches to the study of radionuclides that deposit in bone. The Metals in Bone symposium in Angers was intended to serve a different function from that of the meeting held in Rotterdam in that, while these proceed­ ings will certainly be of interest to non-involved scientists, the meeting was intended to be of most benefit to those actively researching the metabolism and effects of bone-seeking metals. Moreover, in an attempt to increase the value of its discussions and the number of interested and participating scientists, the remit of the meeting was broader and set to include papers on stable as well as radioactive metals. Front Matter....Pages i-xv Front Matter....Pages 1-1 Receptor Molecules, Coprecipitation and Ion Exchange Processes in the Deposition of Metal Ions in Bone....Pages 3-20 Localization of 19m Technetium in Bone....Pages 21-28 The Pattern of Calcium Deposition in Rat Bone as demonstrated by Calcein Labeling....Pages 29-37 Front Matter....Pages 39-39 Iron Metabolism in the Bone Marrow....Pages 41-50 The Study of Damage to Bone Marrow Cells as a Biological Dosimeter after Contamination with Osteotropic α Emitters....Pages 51-61 Functional Damage to Bone Marrow Fibroblasts after Contamination with 241 Americum....Pages 63-70 The Release of Transportable Plutonium from Macrophages: The Effects of Dietary Iron....Pages 71-73 Front Matter....Pages 75-75 Long-Term Retention of Radium in Female Former Dial Workers....Pages 77-85 Strontium-90 Content in Human Bone in West German Residents....Pages 87-95 Long-Term Retention and Turnover Studies with 85 Sr....Pages 97-105 Dynamics of Lifespan Strontium-90 Distribution in Beagles with Uniformly Labelled Skeletons Acquired by Radionuclide Ingestion from In Utero to Adulthood....Pages 107-115 Effect of Stable Strontium on Bone Metabolism in Rats....Pages 117-125 The Distribution of Radium and Plutonium in Human Bone....Pages 127-147 Skeletal Distribution of Stable Strontium and its Incorporation into Bone Mineral In Vivo ....Pages 149-150 Convolution Analysis Applied to Skeletal Uptake of 47 Ca and 85 Sr Measured by External Counting....Pages 151-152 Front Matter....Pages 153-153 Toxicity of Plutonium and Americium: Relationship of Bone Composition to Location of 226 Ra, 239 Pu and 241 Am-Induced Bone Sarcomas....Pages 155-174 Initial Deposition Pattern of Actinides 91 to 96 in the Skeleton of the Rat....Pages 175-197 Pu Microdistribution Study in Cortical Bones of Beagle Dogs....Pages 199-210 Removal of Plutonium and Americium from Various Parts of Rat Skeleton....Pages 211-220 The Retention of Plutonium in Human Bone: A Reconnaissance....Pages 221-228 Front Matter....Pages 153-153 Distribution of Plutonium-239 and Americium-241 in the Human Skeleton....Pages 229-230 Uranium, Thorium and Plutonium in Bones from the General Population of the United States....Pages 231-241 Metabolic Behaviour of Plutonium in Mice....Pages 243-245 Front Matter....Pages 247-247 Microdosimetry of Bone: Implications in Radiological Protection....Pages 249-268 Localized Alpha-Dosimetry for Cancer Induction Studies....Pages 269-284 The Dosimetry of Plutonium-239 in Bones of the Female Mouse and its Relationship to Observed Effects....Pages 285-294 A New Dosimetric Model for Bone Surface Seeking Radionuclides in the Skeleton....Pages 295-296 Variation of Radiation Exposure due to the Administration of Iron-59 in Patients with Different Diseases....Pages 297-299 Front Matter....Pages 301-301 Pathogenesis of Radionuclide-Induced Bone Tumors....Pages 303-320 Effects of Iron Overload on Bone Remodelling in Pigs....Pages 321-331 Skeletal Lesions from Inhaled Plutonium in Beagles....Pages 333-341 The Induction, by 239 Pu of Myeloid Leukaemia and Osteosarcoma in Female CBA Mice (Interim Results)....Pages 343-351 The Effect of Manganese Ingestion, Phosphate Depletion and Starvation on the Epiphyseal Growth Plate....Pages 353-355 Influence of External Irradiation on Sr Deposit in Bone....Pages 357-359 Front Matter....Pages 361-361 The Variation with Flow-Rate of the Extraction of Bone-Seeking Tracers in Recirculation Experiments....Pages 363-372 Chromium Exchange in the Rat Skeleton....Pages 373-382 Historical Changes of Trace Metals in Human Bones from France....Pages 383-393 Some Aspects of Lead Uptake by the Bones....Pages 395-396 Lead Accumulation in Rat’s Bone in Relation to Age....Pages 397-399 The Autoradiographic Method for Lead-210 Quantitative Determination....Pages 401-401 Front Matter....Pages 361-361 Microdistribution of Lead-210 in the Rabbit’s Osseous Tissue....Pages 403-403 Lead in Human Bones and Teeth at the Part-Per-Million Level....Pages 405-406 Comparative Study of the Chemical Behaviour of Trace Elements in Dental Enamel....Pages 407-415 Front Matter....Pages 417-417 Ultrastructural Study of Bone and Small Intestine Cells in Lead-Intoxicated Rats....Pages 419-426 Aluminium Fluoride Inter-Relationships in Renal Failure....Pages 427-432 Evaluation of Different Techniques Used to Determine Aluminium in Patients with Chronic Renal Failure....Pages 433-441 Evaluation of the Role of Aluminium on the Bone Histomorphometry of Uremic Patients....Pages 443-450 In Vitro Modelling of the Role of Aluminium in Inducing Osteomalacia in Dialysis Patients....Pages 451-458 Is Osteomalacia of Renal Osteodystrophy due to Al Intoxication? An Experimental Study in the Rat....Pages 459-460 Back Matter....Pages 461-464