Metallomics and the Cell (Metal Ions in Life Sciences Book 12)

__Metallomics and the Cell__ provides in an authoritative and timely manner in 16 stimulating chapters, written by 37 internationally recognized experts from 9 nations, and supported by more than 3000 references, several tables, and 110 illustrations, mostly in color, a most up-to-date view of the "metallomes" which, as defined in the "omics" world, describe the entire set of biomolecules that interact with or are affected by each metal ion. The most relevant tools for visualizing metal ions in the cell and the most suitable bioinformatic tools for browsing genomes to identify metal-binding proteins are also presented. Thus, MILS-12 is of relevance for structural and systems biology, inorganic biological chemistry, genetics, medicine, diagnostics, as well as teaching, etc. Metallomics and the Cell provides in an authoritative and timely manner in 16 stimulating chapters, written by 37 internationally recognized experts from 9 nations, and supported by more than 3000 references, several tables, and 110 illustrations, mostly in color, a most up-to-date view of the "metallomes" which, as defined in the "omics" world, describe the entire set of biomolecules that interact with or are affected by each metal ion. The most relevant tools for visualizing metal ions in the cell and the most suitable bioinformatic tools for browsing genomes to identify metal-binding proteins are also presented. Thus, this book is of relevance for structural and systems biology, inorganic biological chemistry, genetics, medicine, diagnostics, as well as teaching, etc.Lucia Banci is a bioinorganic chemist and a structural biologist who is studying, among various topics, metal transport and metal homeostasis processes. She is aiming towards a cellular perspective in the spirit of mechanistic systems biology, with the goal of describing functional processes with atomic resolution in a cellular context. Metallomics and the Cell provides in an authoritative and timely manner in 16 stimulating chapters, written by 37 internationally recognized experts from 9 nations, and supported by more than 3000 references, several tables, and 110 illustrations, mostly in color, a most up-to-date view of the "metallomes" which, as defined in the "omics" world, describe the entire set of biomolecules that interact with or are affected by each metal ion. The most relevant tools for visualizing metal ions in the cell and the most suitable bioinformatic tools for browsing genomes to identify metal-binding proteins are also presented. Thus, this book is of relevance for structural and systems biology, inorganic biological chemistry, genetics, medicine, diagnostics, as well as teaching, etc. Lucia Banci is a bioinorganic chemist and a structural biologist who is studying, among various topics, metal transport and metal homeostasis processes. She is aiming towards a cellular perspective in the spirit of mechanistic systems biology, with the goal of describing functional processes with atomic resolution in a cellular context Front Matter....Pages i-xxxvi Metallomics and the Cell: Some Definitions and General Comments....Pages 1-13 Technologies for Detecting Metals in Single Cells....Pages 15-40 Sodium/Potassium Homeostasis in the Cell....Pages 41-67 Magnesium Homeostasis in Mammalian Cells....Pages 69-118 Intracellular Calcium Homeostasis and Signaling....Pages 119-168 Manganese Homeostasis and Transport....Pages 169-201 Control of Iron Metabolism in Bacteria....Pages 203-239 The Iron Metallome in Eukaryotic Organisms....Pages 241-278 Heme Uptake and Metabolism in Bacteria....Pages 279-332 Cobalt and Corrinoid Transport and Biochemistry....Pages 333-374 Nickel Metallomics: General Themes Guiding Nickel Homeostasis....Pages 375-416 The Copper Metallome in Prokaryotic Cells....Pages 417-450 The Copper Metallome in Eukaryotic Cells....Pages 451-478 Zinc and the Zinc Proteome....Pages 479-501 Metabolism of Molybdenum....Pages 503-528 Comparative Genomics Analysis of the Metallomes....Pages 529-580 Back Matter....Pages 581-609 Suitable for structural and systems biology, inorganic biological chemistry, genetics, medicine, diagnostics, as well as teaching, this book presents the relevant tools for visualizing metal ions in the cell and the most suitable bioinformatic tools for browsing genomes to identify metal-binding proteins.