Metal Ions in Biological Systems: Volume 14: Inorganic Drugs in Deficiency and Disease

This book describes drug metal-ion interactions in the gut and deals with the deficiency of zinc and iron and their pharmacological use. It covers anti-inflammatory activities of copper and gold complexes and considers the role of metal ions and chelating agents in anti-viral chemotherapy. Cover Half Title Title Page Copyright Page Preface to The Series Preface to Volume 14 Table of Contents List of Contributors Contents of Other Volumes Chapter 1. Drug-Metal Ion Interaction in the Gut 1. Introduction 2. In Vitro Models of Drug Absorption Interactions 3. Interactions With Metal-Contatning Antacids or Metal Salts 4. Implications of Absorption Interactions on Drug Pharmacokinetic Profiles 5. Clinical Significance of Drug Absorption Interactions with Metal Ions and Metal-containing Antacids References Chapter 2. Zinc Deficiency and its Therapy 1. History 2. Causes of Human Zinc Deficiency 3. Clinical Manifestations of Zinc Deficiency 4. Laboratory Diagnosis of Zinc Deficiency 5. Treatment of Human Zinc Deficiency Acknowledgments References Chapter 3. The Pharmacological use of Zinc 1. History 2. Zinc Absorption 3. Oral Regimens 4. Diseases Which May Respond to Zinc Therapy 5. Mechanism of Action 6. Toxicity 7. The Future Acknowledgments References Chapter 4. The Anti-Inflammatory Activities of Copper Complexes 1. Introduction 2. Normal Physiology of Copper Complexes 3. Altered Physiology of Copper Complexes in Disease with Inflammatory Components 4. Pharmacologic Activities of Copper Complexes 5. Clinical Effectiveness of Copper Complexes in the Treatment of Rheumatoid and other Degenerative Diseases 6. Biochemistry of the Anti-Inflammatory Copper Complexes: Possible Mechanisms of Action 7. Chemistry of Copper Complexes Acknowledgments References Chapter 5. Iron-Containing Drugs 1. Introduction to the Chemistry of Iron 2. Biochemistry of Iron 3. Diseases Basho on Iron 4. Iron Therapy Glossary of Medical Terms References Chapter 6. Gold Complexes as Metallo-Drugs 1. Introduction 2. Gold Drugs Against Arthritis 3. Gold Poisoning, Contraindications, and Treatment 4. Gold Metabolism (Absorption, Distribution, and Excretion) 5. Physical Methods for Determining Interaction of Gold Drugs in Biological Systems 6. Detection and Estimation of Gold in Biological Systems References Chapter 7. Metal Ions and Chelating Agents in Antiviral Chemotherapy 1. Introduction 2. The Viral Cycle and its Impact on Host Organisms 3. Interfering With the Viral Cycle 4. Chelation and Biological Activity 5. Chelatinc agents with Antiviral Activity 6. Delivery of Drugs to Targets 7. Metal Ions in Antiviral Chemotherapy Abbreviations References Chapter 8. Complexes of Hallucinogenic Drugs 1. Introduction 2. The Chemistry of Hallucinogenic Drugs 3. The Role of Metal Ions in the Actions of Drugs 4. Complexes of Hallucinogenic and Related Drugs 5. Conclusions Abbreviations References Chapter 9. Lithium in Psychiatry 1. Introduction 2. Lithium in Psychiatry 3. Chemical Aspects of Lithium 4. Pharmacological and Biochemical Aspects of Lithium 5. Conclusions References Author Index Subject Index