Metal complexes: DNA interactions

Metal ions and metal complexes have long been recognized as critically important components of nucleic acid chemistry, both in regulation of gene expression and as promising therapeutic agents. Understanding how metal complexes interact with DNA has become an active research area at the interface between chemistry, molecular biology and medicine. Metal Complex - DNA Interactions provides a comprehensive overview of this increasingly diverse field, presenting recent developments and the latest research with particular emphasis on metal-based drugs and metal ion toxicity. The text is divided into four parts: Basic Structural and Kinetic Aspects: includes chapters on sequence-selective metal binding to DNA and thermodynamic models. Medical Applications: focuses on anticancer platinum drugs, including discussions on DNA repair in antitumor effects of platinum drugs and photo-dynamic therapy. DNA-Recognition - Nucleases and Sensor: describes probes for DNA recognition, artificial restriction agents, metallo-DNAzymes for metal sensing applications and metal ion dependent catalysis in nucleic acid enzymes. Toxicological Aspects: deals with structural studies of mercury–DNA interactions, chromium-induced DNA damage and repair, and the effect of arsenic and nickel on DNA integrity. This book will be a valuable resource for academic researchers and professionals from a range of pharmaceutical and chemical industries, particularly those involved in the development of new and less toxic anticancer metallo-drugs, and in the field of environmental and toxicological chemistry. Sequence-selective binding of transition metal complexes to DNA / Einar Sletten Thermodynamic models of metal ion-DNA interactions / Vasil Bergadze, Eteri Gelagutashvili, Ketvan Tsakadze Metal ion coordination in G-quadruplexes / Janez Plavec Supramolecular chemistry of metal-nucleobase complexes / P.J. Sanze Miguel ... [et al.] Platinum drugs, nucleotides, and DNA : the role of interligand interactions, nucleotides and DNA / Giovanni Natile and Francesco Cannito Role of DNA repair in antitumor effects of platinum drugs / Viktor Brabec and Jana Kasparkova Telomeres and telomerase : potential targets for platinum complexes / Isabell Ourliac-Garnier, Razan Charif and Sophie Bombard Toward photodynamic therapy of cancer with platinum group matal polyazine complexes / David F. Zigler and Karen J. Brewer Platinated oligonucleotides : synthesis and applications for the control of gene expression / Vicente Marchán and Anna Grandas New titanium and ruthenium anticancer drugs and their interaction with DNA / Kenneth D. Camm and Patrick C. McGowan Groove-binding ruthenium(II) complexes as probes of DNA recognition / Jayden A. Smith, J. Grant Collins and F. Richard Keene DNA recognition and binding by peptide-metal complex conjugate / Alexandra Myari and Nick Hadjiliadis Artificial restriction agents-hydrolytic agents for DNA cleavage / Fabrizio Mancin and Paolo Tecilla New metallo-DNAzymes : fundamental studies of metal-DNA interactions and metal sensing applications / Zehui and Yi Lu Two-metal ion dependent catalysis in nucleic acid enzymes / Wei Yang Mercury- DNA interactions : structural studies on mercuryII-mediated T-T base-pair with NMR spectroscopy / Yoshiyuki Tanaka and Akira Ono Chromium-induced DNA damage and repair / Laura G. Little and Kent D. Sugden Arsenic and nickel : mechanisms affecting DNA integrity / Andrea Hartwig and Tanja Schwerdtle. "Metal ions and metal complexes have long been recognized as critically important components of nucleic acid chemistry, both in regulation of gene expression and as promising therapeutic agents. Understanding how metal complexes interact with DNA has become an active research area at the interface between chemistry, molecular biology and medicine." "Metal Complex-DNA Interactions provides a comprehensive overview of this increasingly diverse field, presenting recent developments and the latest research with particular emphasis on metal-based drugs and metal ion toxicity. This book will be a valuable resource for academic researchers and professionals from a range of pharmaceutical and chemical industries, particularly those involved in the development of new and less toxic anticancer metallo-drugs, and in the field of environmental and toxicological chemistry."--Jacket The importance of metal-DNA interactions in living systems, and their potential applications especially in the treatment and diagnosis of diseases has stimulated considerable recent interest in this area. The most important application is the antitumour action of certain heavy metals, which work by binding to and distorting DNA, causing cell death. For example, Cisplatin (Cl2H6N2Pt) is one of the most potent and widely used anticancer drugs in use today. This book provides an overview of metal-DNA interactions, the mechanism of their interaction, metal-based drugs and metal ion toxicity. It i