Metal Catalyzed Cascade Reactions (Topics in Organometallic Chemistry (19))

Transition metal-catalyzed cascade reactions are an elegant approach to complex molecular scaffolds. Besides their esthetics and increase in structural complexity, they have also become mechanistic challenges for the combination of organometallic elementary steps. As a consequence, cascade reactions have revolutionized synthetic strategies and conceptual thinking. The authors highlight cyclization via carbopalladation and acylpalladation and Heck-pericyclic sequences. They discuss p-allyl palladium-based cascade reactions, Michael-type additions as an entry to transition-metal-promoted cyclizative transformations, and sequential or consecutive palladium-catalyzed processes, and show Pauson-Khand cascades, metal-catalyzed cyclizations of acyclic precursors, as well as cascade and sequential ruthenium-catalyzed transformations. Therefore, the reader finds overview of an exciting and highly dynamic field of a new and innovative methodological concept. Palladium-Catalyzed Cyclization via Carbopalladation and Acylpalladation....Pages 1-48 Domino Heck-Pericyclic Reactions....Pages 49-89 Palladium Catalyzed Cascade Reactions Involving π-Allyl Palladium Chemistry....Pages 91-113 The Virtue of Michael-Type Addition Processes in the Design of Transition Metal-Promoted Cyclizative Cascade Reactions....Pages 115-148 Sequentially Palladium-Catalyzed Processes....Pages 149-205 Cascade Reactions Involving Pauson–Khand and Related Processes....Pages 207-257 Complex Polycyclic Molecules from Acyclic Precursors via Transition Metal-Catalyzed Cascade Reactions....Pages 259-294 Cascade and Sequential Catalytic Transformations Initiated by Ruthenium Catalysts....Pages 295-326 This Book Highlights Cyclization Via Carbopalladation And Acylpalladation And Heck-pericyclic Sequences. They Discuss P-allyl Palladium-based Cascade Reactions, Michael-type Additions As An Entry To Transition-metal-promoted Cyclizative Transformations, And Sequential Or Consecutive Palladium-catalyzed Processes, And Show Pauson-khand Cascades, Metal-catalyzed Cyclizations Of Acyclic Precursors, As Well As Cascade And Sequential Ruthenium-catalyzed Transformations. This Is A Comprehensive Overview Of An Exciting And Highly Dynamic, And Innovative Methodological Concept.