Metabolism of Human Diseases : Organ Physiology and Pathophysiology

“__Metabolism of Human Diseases__” examines the physiology of key organs (e.g. brain, eye, lung, heart, blood vessels, blood, immune system, gastrointestinal tract, pancreas, liver, fat tissue, kidney, reproductive system, teeth, bone and joints) and how defective metabolism and signaling pathways within these organs contribute to common human diseases. The latter include depression, schizophrenia, epilepsy, Parkinson's disease, Alzheimer's disease, migraine, multiple sclerosis, Down syndrome, macular degeneration, glaucoma, asthma, COPD, pneumonia, atherosclerotic heart disease, heart failure, stroke, varicose veins, Sickle cell disease, hyperlipidemia, fever, sepsis, allergies, peptic ulcer, gastroenteritis, lactose intolerance, colon cancer, diabetes, cirrhosis, metabolic syndrome, hypertension, chronic kidney disease, gout, urinary tract infections, kidney stones, dental caries, osteoporosis, osteoarthritis, rheumatoid arthritis, breast cancer and prostate cancer. The book also describes commonly used drugs and explains their molecular targets. It provides the first comprehensive and detailed summary of the metabolism of individual organs and their physiological and pathological functioning. Thus it serves as a useful supplement to previous textbooks of human physiology. “__Metabolism of Human Diseases__”is a must-have, state-of-the-art textbook written by International experts for graduate students, postdocs and scientists in metabolic research, biochemistry, physiology and pharmacy as well as for physicians interested in molecular mechanisms underlying common human diseases. Front Matter....Pages i-ix Introduction....Pages 1-2 Front Matter....Pages 3-3 Overview....Pages 5-10 Major Depressive Disorder....Pages 11-16 Schizophrenia....Pages 17-22 Epilepsy....Pages 23-27 Parkinson’s Disease....Pages 29-33 Alzheimer’s Disease....Pages 35-40 Migraine and Cluster Headache....Pages 41-45 Multiple Sclerosis....Pages 47-52 Down Syndrome....Pages 53-56 Front Matter....Pages 57-57 Overview....Pages 59-65 Age-Related Macular Degeneration....Pages 67-72 Glaucoma....Pages 73-77 Front Matter....Pages 79-79 Overview....Pages 81-85 Dental Caries....Pages 87-92 Osteoporosis....Pages 93-98 Front Matter....Pages 99-99 Overview....Pages 101-106 Osteoarthritis....Pages 107-113 Rheumatoid Arthritis....Pages 115-120 Front Matter....Pages 121-121 Overview....Pages 123-128 Front Matter....Pages 121-121 Peptic Ulcer Disease....Pages 129-135 Gastroenteritis....Pages 137-142 Lactose Intolerance....Pages 143-148 Colorectal Cancer....Pages 149-154 Front Matter....Pages 155-155 Overview....Pages 157-162 Diabetes Mellitus....Pages 163-169 Front Matter....Pages 171-171 Overview....Pages 173-179 Cirrhosis....Pages 181-187 Front Matter....Pages 189-189 Overview....Pages 191-197 Metabolic Syndrome....Pages 199-203 Front Matter....Pages 205-205 Overview....Pages 207-213 Asthma....Pages 215-219 Chronic Obstructive Pulmonary Disease (COPD)....Pages 221-226 Community-Acquired Pneumonia....Pages 227-231 Front Matter....Pages 233-233 Overview....Pages 235-242 Atherosclerotic Heart Disease....Pages 243-249 Heart Failure....Pages 251-257 Front Matter....Pages 259-259 Overview....Pages 261-266 Stroke....Pages 267-271 Varicose Veins....Pages 273-277 Front Matter....Pages 279-279 Overview....Pages 281-287 Sickle Cell Disease....Pages 289-293 Hyperlipidemia....Pages 295-302 Front Matter....Pages 303-303 Overview....Pages 305-311 Fever....Pages 313-317 Sepsis....Pages 319-322 Allergies....Pages 323-328 Front Matter....Pages 329-329 Overview....Pages 331-337 Hypertension....Pages 339-344 Chronic Kidney Disease....Pages 345-350 Gout....Pages 351-356 Urinary Tract Infections....Pages 357-360 Kidney Stones....Pages 361-365 Front Matter....Pages 367-367 Overview....Pages 369-377 Breast Cancer....Pages 379-384 Prostate Cancer....Pages 385-390 Front Matter....Pages 391-391 Overview....Pages 393-399 Back Matter....Pages 401-416 “ Metabolism of Human Diseases ” examines the physiology of key organs (e.g. brain, eye, lung, heart, blood vessels, blood, immune system, gastrointestinal tract, pancreas, liver, fat tissue, kidney, reproductive system, teeth, bone and joints) and how defective metabolism and signaling pathways within these organs contribute to common human diseases. The latter include depression, schizophrenia, epilepsy, Parkinson's disease, Alzheimer's disease, migraine, multiple sclerosis, Down syndrome, macular degeneration, glaucoma, asthma, COPD, pneumonia, atherosclerotic heart disease, heart failure, stroke, varicose veins, Sickle cell disease, hyperlipidemia, fever, sepsis, allergies, peptic ulcer, gastroenteritis, lactose intolerance, colon cancer, diabetes, cirrhosis, metabolic syndrome, hypertension, chronic kidney disease, gout, urinary tract infections, kidney stones, dental caries, osteoporosis, osteoarthritis, rheumatoid arthritis, breast cancer and prostate cancer. The book also describes commonly used drugs and explains their molecular targets. It provides the first comprehensive and detailed summary of the metabolism of individual organs and their physiological and pathological functioning. Thus it serves as a useful supplement to previous textbooks of human physiology. “ Metabolism of Human Diseases ” is a must-have, state-of-the-art textbook written by International experts for graduate students, postdocs and scientists in metabolic research, biochemistry, physiology and pharmacy as well as for physicians interested in molecular mechanisms underlying common human diseases.