Metabolism In Cancer (recent Results In Cancer Research)

This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications. Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy. Front Matter....Pages i-ix The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells....Pages 1-22 Lactate—An Integrative Mirror of Cancer Metabolism....Pages 23-37 Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer....Pages 39-72 MYC, Metabolic Synthetic Lethality, and Cancer....Pages 73-91 The Role of pH Regulation in Cancer Progression....Pages 93-134 Metabolic Features of Cancer Treatment Resistance....Pages 135-156 Tissue-Based Metabolomics to Analyze the Breast Cancer Metabolome....Pages 157-175 Imaging of Tumor Metabolism Using Positron Emission Tomography (PET)....Pages 177-205 Quantitative Analysis of Cancer Metabolism: From pSIRM to MFA....Pages 207-220 Mathematical Modeling of Cellular Metabolism....Pages 221-232 Ketogenic Diet and Cancer—a Perspective....Pages 233-240 Fasting and Caloric Restriction in Cancer Prevention and Treatment....Pages 241-266 Contributors; Description and Purpose of the Work; The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells; Lactate - an integrative mirror of cancer metabolism ; Metabolic reprogramming by the PI3K-Akt-mTOR pathway in cancer ; MYC, metabolic synthetic lethality, and cancer ; The role of pH regulation in cancer progression ; Metabolic features of cancer treatment resistance ; Tissue-based metabolomics to analyze the breast cancer metabolome ; Imaging of tumor metabolism using positron emission tomography (PET) ; Quantitative analysis of cancer metabolism: from pSIRM to MFA ; Mathematical modelling of cellular metabolism ; Ketogenic diet and cancer - a perspective ; Fasting and caloric restriction in cancer prevention Thorsten Cramer, Clemens A. Schmitt, Editors. Includes Bibliographical References.