Metabolic Effects of Psychotropic Drugs (Modern Trends in Pharmacopsychiatry Vol 26)

Major depression and bipolar disorder are chronic enduring serious mental illnesses (SMI) with devastating effects on psychosocial functioning and may culminate in suicide. Over the past years, it has become apparent that subjects with these conditions can also develop the metabolic syndrome, which is a series of obesity-related physical conditions with an endocrine basis. This book brings together reviews that help put into context exactly why subjects with SMI develop obesity, prediabetic status, overt type 2 diabetes mellitus and related cardiovascular events. The relationship between prolactin and bone mineral density in subjects under medical treatment and the underlying dopaminergic mechanisms as well as the immunological changes occurring as an integral part of SMI and their effects on endocrine function are discussed and reviewed. Psychiatrists, diabetologists, cardiologists, family practitioners, public health physicians as well as basic science researchers will find valuable guidelines when screening for type 2 diabetes mellitus and cardiovascular disease in SMI. Metabolic syndrome and schizophrenia : is inflammation the cause? / Leonard, B.E. Insulin resistance in bipolar women : effects of mood-stabilizing drugs / Vemuri, M. ... [et al.] Obesity and mental illness / Citrome, L., Vreeland, B. Glucose abnormalities in schizophrenia, bipolar, and major depressive disorders / Bushe, C. Screening for diabetes and cardiovascular risk factors in people with serious mental illness / Holt, R.I.G., Peveler, R.C. Stress axis dysfunction : a common finding in schizophrenia and the metabolic syndrome? / Afzal, A., Thakore, J. Metabolic syndrome in psychiatric inpatients treated for depression / Goethe, J.W., Szarek, B.L., Caley, C.F. Hyperprolactinaemia associated with antipsychotic medications / Fitzgerald, P., Dinan, T.G. Impact of hyperprolactinaemia on the general health of patients with schizophrenia / Wildgust, H.J., Kohen, D. cover......Page 1 1 Title Page.pdf......Page 2 2 Metabolic Syndrome and Schizophrenia Is Inflammation the Cause......Page 10 3 Insulin Resistance in Bipolar Women Effects of Mood-Stabilizing Drugs......Page 21 4 Obesity and Mental Illness......Page 34 5 Glucose Abnormalities in Schizophrenia, Bipolar and Major Depressive Disorders......Page 56 6 Screening for Diabetes and Cardiovascular Risk Factors in People with Serious Mental Illness......Page 75 7 Stress Axis Dysfunction A Common Finding in Schizophrenia and the Metabolic Syndrome......Page 91 8 Metabolic Syndrome in Psychiatric Inpatients Treated for Depression......Page 99 9 Hyperprolactinaemia Associated with Antipsychotic Medications......Page 114 10 Impact of Hyperprolactinaemia on the General Health of Patients with Schizophrenia......Page 125 Author Index......Page 138 Subject Index......Page 139