Metabolic Basis of Detoxication: Metabolism of Functional Groups (Biochemical Pharmacology and Toxicology)

Metabolic Basis of Detoxication: Metabolism of Functional Groups considers the possible fates of the relatively circumscribed number of functional groups that xenobiotics bear. An understanding of the possible reactions, and the chemical and biological factors influencing them, will contribute to the overall predictability of the fate of "real" molecules. This approach attempts to knit together the understanding of metabolic pathways with that of the enzymes that catalyze the specific steps. The book contains 18 chapters and begins with a discussion of the biological oxidation of carbon atoms. This is followed by separate chapters on the metabolism of halogenated aliphatic hydrocarbons, aryl halides, heterocyclic rings, alcohols, aldehydes, and ketones. Subsequent chapters cover oxidative processes such as metabolic dealkylations and biological oxidation at nitrogen centers; the reduction of nitro and azo compounds and tertiary amine N-oxides; the oxidation, alkylation, acylation, and glycosylation of mercaptans; epoxide metabolism; and conjugation of phenols. The book aims to inform and interest the pharmacologist and toxicologist concerning the biochemical aspects and to orient the biochemist to the pharmacological insights required in dealing with the metabolism of xenobiotics. Content: BIOCHEMICAL PHARMACOLOGY AND TOXICOLOGY: A Series of Monographs , Page ii Front Matter , Page iii Copyright , Page iv Contributors , Pages xi-xii Preface , Page xiii Introduction , Pages 1-3 Chapter 1 - Oxidation of Foreign Compounds at Carbon Atoms , Pages 5-28 Chapter 2 - Aliphatic Halogenated Hydrocarbons , Pages 29-49 Chapter 3 - Aryl Halides , Pages 51-68 Chapter 4 - Oxidative Metabolism of Heterocyclic Ring Systems , Pages 69-89 Chapter 5 - Alcohols, Aldehydes, and Ketones , Pages 91-104 Chapter 6 - N-Dealkylation and Deamination , Pages 105-126 Chapter 7 - Oxidation at Nitrogen Centers , Pages 127-149 Chapter 8 - Reductive Metabolism of Nitrogen-Containing Functional Groups , Pages 151-170 Chapter 9 - Functional Groups Bearing Sulfur , Pages 171-184 Chapter 10 - Mercaptans , Pages 185-206 Chapter 11 - Metabolism of Epoxides , Pages 207-228 Chapter 12 - Hydrolysis of Carboxylic Esters and Amides , Pages 229-245 Chapter 13 - Conjugation of Phenols , Pages 247-269 Chapter 14 - Conjugation of Xenobiotic Carboxylic Acids , Pages 271-290 Chapter 15 - Conjugation Reactions of Nitrogen Centers , Pages 291-306 Chapter 16 - Metabolism of Organic Hydroperoxides , Pages 307-321 Chapter 17 - Role of the Intestinal Microflora , Pages 323-337 Chapter 18 - Metabolism and Urinary Excretion , Pages 339-357 Index , Pages 359-375