Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells

Research has shown that the lung is capable of metabolically activating xenobiotics into intermediates that can covalently bind to pulmonary tissue. Further, it has been shown that the lung consists of many distinct cell types with the ability to take up and sequester metabolically unchanged drugs and chemicals that are ultimately toxic in effect. This volume reflects the extent of these developments and provides a state-of-the art reference in a rapidly evolving field incorporating both drug metabolism and pulmonary toxicology research. Content: EDITORIAL BOARD , Page ii Front Matter , Page iii Copyright , Page iv PREFACE , Page v , Theodore E. Gram LIST OF CONTRIBUTORS , Pages xv-xvi CHAPTER 1 - PULMONARY BRONCHIOLAR EPITHELIAL CYTOTOXICITY: MICROANATOMICAL CONSIDERATIONS , Pages 1-24 , C.G. PLOPPER CHAPTER 2 - XENOBIOTIC METABOLISM BY ISOLATED PULMONARY BRONCHIOLAR AND ALVEOLAR CELLS , Pages 25-40 , THEODORA R. DEVEREUX, BARBARA A. DOMIN, RICHARD M. PHILPOT CHAPTER 3 - LOCALIZATION, DISTRIBUTION AND INDUCTION OF XENOBIOTIC-METABOLIZING ENZYMES AND ARYL HYDROCARBON HYDROXYLASE ACTIVITY WITHIN LUNG , Pages 41-75 , JEFFREY BARON, JEFFREY M. VOIGT CHAPTER 4 - PURIFICATION AND CHARACTERIZATION OF LUNG ENZYMES INVOLVED IN XENOBIOTIC METABOLISM , Pages 77-87 , F. PETER GUENGERICH CHAPTER 5 - ACTION BY THE LUNGS ON CIRCULATING XENOBIOTIC AGENTS, WITH A CASE STUDY OF PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING OF BENZO(a)PYRENE DISPOSITION , Pages 89-105 , ROBERT A. ROTH, ALLEN VINEGAR CHAPTER 6 - METABOLISM OF ENDOGENOUS AND XENOBIOTIC SUBSTANCES BY PULMONARY VASCULAR ENDOTHELIAL CELLS , Pages 107-122 , UNA S. RYAN, ALBERT P. LI CHAPTER 7 - NAPHTHALENE AND 2-METHYLNAPHTHALENE-INDUCED PULMONARY BRONCHIOLAR EPITHELIAL CELL NECROSIS: METABOLISM AND RELATIONSHIP TO TOXICITY , Pages 123-144 , RONALD B. FRANKLIN, CHARLES G. PLOPPER, ALAN R. BUCKPITT CHAPTER 8 - PULMONARY TOXICITY OF 4-IPOMEANOL , Pages 145-152 , THEODORE E. GRAM CHAPTER 9 - PULMONARY TOXICITY INDUCED BY PHOSPHOROTHIOATE IMPURITIES PRESENT IN ORGANOPHOSPHATE INSECTICIDES , Pages 153-163 , JAY GANDY, STEPHEN K. DURHAM, TOSHIKO IMAMURA CHAPTER 10 - THE METABOLIC BASIS OF 3-METHYLINDOLE-INDUCED PNEUMOTOXICITY , Pages 165-184 , Tammy M. Bray, James B. Kirkland METABOLISM AND PULMONARY TOXICITY OF BUTYLATED HYDROXYTOLUENE , Pages 185-212 , HANSPETER WITSCHI, ALVIN M. MALKINSON, JOHN A. THOMPSON CHAPTER 12 - HEPATIC NONALTRUISM AND PULMONARY TOXICITY OF PYRROLIZIDINE ALKALOIDS , Pages 213-237 , RYAN J. HUXTABLE CYCLOPHOSPHAMIDE: PULMONARY METABOLISM, TOXICITY AND PROTECTIVE EFFECT OF VITAMIN E , Pages 239-254 , J.M. PATEL CHAPTER 14 - METABOLIC ACTIVATION AND BIOLOGICAL EFFECTS OF NITROSAMINES IN THE MAMMALIAN LUNG , Pages 255-266 , HILDEGARD M. SCHÜLLER, MIRIAM FALZON, JAMES B. MCMAHON CHAPTER 15 - THE USE OF BLEOMYCIN IN MODEL SYSTEMS TO STUDY THE PATHOGENESIS OF INTERSTITIAL PULMONARY FIBROSIS , Pages 267-283 , JOHN S. LAZO, DALE G. HOYT, SAID M. SEBTT, BRUCE R. PITT CHAPTER 16 - THE PULMONARY TOXICITY OF NITROSOUREAS , Pages 285-303 , ADALINE C. SMITH INDEX , Pages 305-308