Mesotheliomas of Animals : A Comprehensive, Tabular Compendium of the World's Literature

Idiopathic -- Spontaneous -- Lower vertebrates -- Avian -- Rodents -- Bovine -- Feline -- Canine -- Equine -- Marsupials -- Porcine -- Ovine -- Controls -- Untreated -- Treated -- Sham -- Saline injection -- Nonfibrous dust -- Non carcinogenic implant -- Unspecified treatments -- Oil & gelatin -- Fibrous agents -- Natural fibres -- Asbestiform (including fibrous clays) -- Amosite -- Administered alone -- Coadministered -- Dose response studies -- Chrysotile -- Crocidolite -- Other natural fibres -- Administered alone -- Actinolite -- Anthophyllite -- Attapulgite -- Brucite -- Dawsonite -- Ferroactinolite -- Gypsumscite -- Halloysite -- Mg-arphvedsonite -- Marl -- Nemalite -- Palygorskite -- Pectinolite -- Quartz -- Sepiolite -- Silica & silicates -- Talc -- Tremolite -- Wollastonite -- Coadministered -- Dose response studies -- Asbestos fibres of unspecified type -- Administered alone -- Baker's unwashed -- (Na, Mg) synthetic -- Rhodesian -- Cement -- King's float -- Prefab pipe cover -- Coadministered -- Nonasbestiform fibres -- Zeolites -- Administered alone -- Dose response studies.;(cont) Man made mineral fibres -- Administered alone -- Fibrous glasses -- Specified types no. 100, no. 104, no. 106 & 110 -- Borosilicates -- Fibrefrax, filament & fybex -- Unspecified types -- Mineral wools -- Ceramic fibres -- Aramid-kevlar -- Coadministered -- Nonfibrous agents -- Chemicals -- Administered alone -- Acetamide N-2-flourenyl (AAF) -- Apholate, aphoxide & azaxanthine Benzo (a) pyrene -- Diethylstilbesterol -- Dichloro-3-nitronaphthalene (1,2) -- Dichlorobucil -- Dimethyl-4-amino-5-nitrosouracil -- Dimethlyacetamide (N, N) -- Dimethylaminostyrl benzothiazole (3,4) -- Methyl (acetoxy methyl) nitrosamine -- Estrogen synthetic -- Ethylene oxide -- Methyl-1-naphthylamine (3) -- Methylene-bis-(2-chloraniline) -- Methyl nitroso urea (MNU) -- Neohesperidin -- N-ethyl-N-nitrosourea (ENU) -- N-propyl-N-nitrosourea (PNU) -- Nitrolotrispropionamide -- Nitrosonaphthylamine -- Nitrosopyrrolide -- Nitrotriacetic acid (NTA) -- Potassium bromate (KBrO3) -- Sterigmatocystin -- Stilbesterol -- Trimethylcholanthrene (TMCA) -- Coadministered -- Dose response studies -- Metals -- Administered alone.;(cont) Aluminium oxide, nitride & carbonate -- Arsenic -- Barium -- Beryllium -- Cadmium -- Chromate sulfide, calcium, trioxide -- Chromite & chromium -- Cobalt -- Corundum -- Ferric oxide -- Magnetite -- Nickel subsulfide & oxide -- Plutonium dioxide -- Titanium dioxide -- Uranium -- Dose response studies -- Polymers -- Administered alone -- Aerosil -- Dextran -- Gelatine capsules -- Metaphosphate -- Polyether -- Polyethylene -- Polypropylene -- Polysilicone -- Polyurethane -- Polyvinyl chloride -- Polyvinyl alcohol -- Silastic rubber -- Viruses -- Administered alone -- BH-RSV (RAV-2) -- pJD-11 -- pRL v-src -- SV-40 -- MC 29 Leukosis -- T12 adeno -- Polyoma -- SE -- Coadministered -- Dose response studies.;Mesotheliomas of Animals is the first book to provide a comprehensive compilation of the diverse and often disparate literature regarding animal mesotheliomas. The compendium presents evidence to support the existence of "background" and "threshold," both of which are concepts central to the controversy surrounding nonasbestos-related mesotheliomas. Examples of "background" tumors (those which are nonasbestos-related) are described in detail, and indications of "threshold" for the induction of mesotheliomas following exposure to asbestiform and nonasbestiform agents are evident from the "positive dose-response" studies that are discussed. This compendium also allows for easy comparison of tumor yields elicited in "inoculation" studies performed with the same fiber types at similar doses. These comparisons often demonstrate markedly different tumor yields and highlight the limitations of injection techniques for fiber safety assessment. Mesotheliomas of Animals will be an essential reference for industrial hygienists, environmental lawyers, cancer researchers, and pulmonary scientists. It will be particularly useful to anyone involved with the design of fiber safety tests or with developing experimental models and protocols to assess the manner in which mesotheliomagenesis occurs. Cover......Page 1 Title Page......Page 2 Copyright Page......Page 3 Abstract......Page 4 Foreword......Page 5 Dedication......Page 6 Introduction......Page 8 Acknowledgements......Page 19 Table of Contents......Page 20 Lower Vertebrates......Page 26 Avian......Page 30 Rodents......Page 31 Bovine......Page 40 Feline......Page 61 Canine......Page 63 Equine......Page 75 Marsupials......Page 77 Ovine......Page 78 Untreated......Page 80 Sham......Page 84 Saline Injection......Page 85 Nonfibrous Dust......Page 87 Non Carcinogenic Implant......Page 88 Oil & Gelatin......Page 90 Administered Alone......Page 91 Coadministered......Page 107 Dose Response Studies......Page 110 Administered Alone......Page 114 Coadministered......Page 165 Administered Alone......Page 181 Coadministered......Page 191 Administered Alone......Page 194 Coadministered......Page 215 Administered Alone......Page 223 Coadministered......Page 228 Actinolite......Page 231 Anthophyllite......Page 232 Attapulgite......Page 235 Brucite......Page 236 Dawsonite......Page 237 Gypsumscite......Page 238 Nemalite......Page 239 Pectinolite......Page 240 Sepiolite......Page 241 "Silica & Silicates"......Page 242 Talc......Page 243 Tremolite......Page 244 Wollastonite......Page 246 Coad ministered......Page 248 Dose Response Studies......Page 250 (Na, Mg) Synthetic......Page 252 Cement......Page 253 "King's Float"......Page 256 Prefab Pipe Cover......Page 257 Coad ministered......Page 259 Administered Alone......Page 261 Dose Response Studies......Page 274 No. 100......Page 281 No. 104......Page 283 No. 106 & 110......Page 287 Borosilicates......Page 288 Fibrefrax, Filament, & Fybex......Page 291 Unspecified Types......Page 293 Mineral Wools......Page 307 Ceramic Fibres......Page 312 Aramid - Kevlar......Page 315 Coadministered......Page 318 Apholate, Aphoxide, & Azaxanthine......Page 319 Diethylstilbesterol......Page 320 Dimethlyacetamide (N,N)......Page 322 Methyl (acetoxy methyl) Nitrosamine......Page 323 Ethylene Oxide......Page 324 Methyl Nitroso Urea (MNU)......Page 325 N - ethyl - N - nitrosourea (ENU)......Page 326 N - propyl - N - nitrosourea (PNU)......Page 327 Potassium Bromate (KBrO3)......Page 328 Trimetbylcbolanthrene (TMCA)......Page 329 Coad ministered......Page 330 Dose Response Studies......Page 338 Aluminium oxide, nitride, & carbonate......Page 341 Barium......Page 343 Cadmium......Page 344 Chromate sulfide, calcium, trioxide......Page 345 Cobalt......Page 346 Nickel subsulfide & oxide......Page 347 Plutonium dioxide......Page 348 Uranium......Page 350 Dose Response Studies......Page 351 Polypropylene......Page 352 Polyurethane......Page 353 Silastic Rubber......Page 359 MC 29 Leukosis......Page 360 T12Adeno......Page 361 SE......Page 362 Coadministered......Page 363 Dose Response Studies......Page 364 Bibliocnphy Asbestos Meso......Page 366