Mesenchymal Stromal Cells: Biology and Clinical Applications (Stem Cell Biology and Regenerative Medicine)

Mesenchymal Stromal Cell (MSC) biology has been studied for more than 4 decades and the cells have been investigated for potential clinical applications for more than 15 years. Progress has become exponential over the past decade due mainly to the broad therapeutic potential of these cells. However, MSC studies have also been subject to controversy and increasing scrutiny as new mechanisms of action are reported and ever-expanding therapeutic applications pursued. In this book, leading authorities from all over the world, who are actively involved in this field, provide state-of-the-art knowledge of the basic biology, translational requirements and latest clinical experience with MSCs. This cutting edge book is the ideal resource for scientists and clinicians interested in pursuing an important and rapidly developing field of research that will eventually help patients and address urgent unmet medical needs. Features include: * Coverage of the biology of MSCs, latest understanding of mechanisms of action, and role in tissue homeostasis and regeneration * Identifying the potential of MSCs in proceeding from bench to bedside from regulatory , GMP production, ethical and safety aspects * Critical analysis of clinical studies and the potential of MSCs to treat a wide variety of human diseases and tissues. Front Matter....Pages i-xxvi Front Matter....Pages 1-1 Mesenchymal Stromal Cells in Regenerative Medicine: A Perspective....Pages 3-16 MSCs: Changing Hypotheses, Paradigms, and Controversies on Mechanisms of Action in Repairing Tissues....Pages 17-42 MSCs: The Need to Rethink....Pages 43-57 Characterization of MSCs: From Early Studies to the Present....Pages 59-77 MSCs as Therapeutics....Pages 79-90 MSC Niche for Hematopoiesis....Pages 91-106 Immunomodulatory Properties of MSCs....Pages 107-134 MSCs and Innate Immune Responses: A Balancing Act....Pages 135-143 MSCs: Paracrine Effects....Pages 145-167 Cross-Talk Between MSCs and Their Environments....Pages 169-192 Human MSCs from Bone Marrow, Umbilical Cord Blood, and Adipose Tissue: All the Same?....Pages 193-208 MSCs in Solid Tumors and Hematological Malignancies: From Basic Biology to Therapeutic Applications....Pages 209-235 MSC Studies in Large-Animal Models....Pages 237-258 Defining the Potential of MSCs with a Prenatal Large Animal Model....Pages 259-275 Front Matter....Pages 277-277 Bench-to-Bedside Development of MSC Therapies: A Multidisciplinary Approach....Pages 279-315 cGMP Production of MSCs....Pages 317-341 MSCs: The US Regulatory Perspective....Pages 343-354 MSCs: Clinical Applications and European Regulatory Aspects....Pages 355-364 Stem Cell Treatments Around the World: Boon or Bane?....Pages 365-376 Safety Issues in MSC Therapy....Pages 377-387 Front Matter....Pages 277-277 In Vivo Imaging of MSCs....Pages 389-402 National Heart, Lung, and Blood Institute Support of Cellular Therapies Regenerative Medicine....Pages 403-423 Front Matter....Pages 425-425 MSC Therapy of Inborn Errors....Pages 427-441 MSCs for Enhancement of Hematopoietic Progenitor Cell Engraftment and Poor Graft Function....Pages 443-454 MSCs for Graft-Versus-Host Disease....Pages 455-465 MSCs in Pediatric Hematopoietic Stem Cell Transplantation....Pages 467-483 MSC for Ex Vivo Expansion of Umbilical Cord Blood Cells....Pages 485-501 MSCs for Autoimmune Diseases....Pages 503-517 MSCs for Induction of Solid Organ Allograft Acceptance....Pages 519-527 MSCs for Gastrointestinal Disorders....Pages 529-540 MSCs for Cardiac Repair....Pages 541-559 MSCs for Treatment of Acute Lung Injury....Pages 561-570 MSCs for Diabetes....Pages 571-597 MSCs for Renal Repair....Pages 599-615 MSCs for the Treatment of Stroke, Spinal Cord Injury, and Traumatic Brain Injury: From Bench Work to Clinical Trials....Pages 617-637 MSCs in Reconstructive Surgery....Pages 639-653 MSCs in Orthopedic Surgery....Pages 655-662 Adipose Tissue-Derived MSCs: Moving to the Clinic....Pages 663-681 Back Matter....Pages 683-695 In this book, leading authorities actively involved in this field provide state-of-the-art knowledge of the basic biology, translational requirements and latest clinical experience with Mesenchymal Stromal Cell (MSC) biology.