سلول‌های بنیادی مزانشیمی در سلامت و بیماری‌های انسان

Mesenchymal Stem Cells in Human Health and Diseases provides a contemporary overview of the fast-moving field of MSC biology, regenerative medicine and therapeutics. MSCs offer the potential to dramatically reduce human suffering from disease. Numerous MSC-based studies are ongoing each year, each offering hope for novel treatments in human disease. This book provides information on MSC application in well-studied human diseases and tissue repair/regeneration and recent advances in their research and treatment. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in our understanding of MSC biology. Includes insights ranging from MSC biology and development through the derivation and identification and properties of MSCs Helps to identify potential innovative solutions for restoring normal morphogenesis and/or regeneration of diseased organs Discusses the fact-based promise of MSC therapeutics and regenerative medicine in the real world Cover Mesenchymal Stem Cells in Human Health and Diseases Copyright Dedication How To Use Contributors About the editor Foreword by Alexzander A.A. Asea Foreword by Junfeng Ji Preface Acknowledgments 1 - Mesenchymal stem cells in regenerative medicine and diseases: hope for better human health References Further reading 2 - Application of mesenchymal stem cells in human diseases Introduction: background and driving forces History of mesenchymal stem cells Function of mesenchymal stem cells Mesenchymal stem cells as seed cells participate in tissue regeneration Mesenchymal stem cells for myocardial injury Mesenchymal stem cells for osteoarthritis, lower back pain, and cartilage repair Mesenchymal stem cells for pulmonary disease Mesenchymal stem cells for liver disease Mesenchymal stem cells for gastrointestinal disease Mesenchymal stem cells as modulators participate in tissue homeostasis and regeneration Controversy over and expectations for mesenchymal stem cells Conclusion References 3 - Immunoregulatory properties of mesenchymal stem cells and their application in immunotherapy Immunomodulatory effects of mesenchymal stem cells Mechanisms of antiinflammatory effects of mesenchymal stem cells Prospective and concluding remarks References 4 - Stem cell therapies in ocular repair, regeneration, and diseases Introduction Stem cell therapy for retinal diseases Stem cell therapy for corneal diseases Corneal stem cell types Corneal and limbal stem cell markers Regulatory factors of limbal stem cell proliferation Stem cell therapeutic approaches for corneal diseases Limbal stem cell deficiency The management of patients with limbal stem cell deficiency Conjunctival limbal autografts Living related conjunctival limbal allograft Cadaveric keratolimbal allografts Simple limbal epithelial transplantation Ex vivo expansion limbal stem cell transplantation Cultivated oral mucosal epithelial transplantation Conclusions, challenges and future directions References Further reading 5 - Applications of the stem cell secretome in regenerative medicine Introduction The potential of stem cells in regenerative medicine The concept of the secretome Modulation of the stem cell secretome profile Three-dimensional cultures and biomaterials Preconditioning of stem cells Bioreactors Application of the stem cell secretome in CNS disorders Stroke Traumatic brain injury Parkinson disease Spinal cord injury Concluding remarks References 6 - Innovation in induced mesenchymal stem cell uses in therapy Introduction Major sources of induced mesenchymal stromal/stem cells Induced mesenchymal stromal/stem cell applications in cell therapy Conclusion References 7 - Role of mesenchymal stem cells in bone fracture repair and regeneration Introduction Sources of mesenchymal stem cells for bone regeneration Mesenchymal stem cell homing in bone regeneration Molecular mechanisms affecting mesenchymal stem cell homing External factors affecting mesenchymal stem cell homing The application of mesenchymal stem cells in bone tissue regeneration Immunogenicity of mesenchymal stem cells The isolation and treatment approach of mesenchymal stem cells Genetically modified mesenchymal stem cells for bone regeneration Application of biological materials and growth factors in mesenchymal stem cell bone repair Clinical consequences Conclusion References 8 - Tendon stem cells and their interaction with microenvironments Introduction Isolation and culture of tendon stem/progenitor cells Characterization of tendon stem/progenitor cells Culture conditions Cell passage and senescence Growth factors Mechanical stimulation Extracellular matrix and scaffold Clinical relevance: the role of tendon stem/progenitor cells in tendon disease Conclusion and forecast Acknowledgments References 9 - Mesenchymal stem cell roles in osteoarthritis (joint) disease Conclusion References Further reading 10 - Mesenchymal stem cells and cancer therapy Introduction The application of mesenchymal stem cells in cancer treatments Limiting factors of the mesenchymal stem cell–mediated cancer therapies Conclusions and future directions References 11 - Mesenchymal stem cells in human health and diseases: general discussion, remarks, and future directions References Index A B C G H I L M N O P R S T V