اکسوزوم‌های مشتق از سلول‌های بنیادی مزانشیمی: پتانسیل برای نانومدیسین ترجمه‌ای

Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. __Mesenchymal Stem Cell Derived Exosomes__ provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool.* Introduces the MSC-exosome mediated cell-cell communication * Covers the major functional benefits in current MSC-derived exosome studies * Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies Content: Front matter,Copyright,List of Contributors,PrefaceEntitled to full textChapter 1 - Insights into the Mechanism of Exosome Formation and Secretion, Pages 1-19 Chapter 2 - An Overview of the Proteomic and miRNA Cargo in MSC-Derived Exosomes, Pages 21-36 Chapter 3 - Exosome Function in miRNA-Mediated Paracrine Effects, Pages 37-62 Chapter 4 - Current Methods to Purify and Characterize Exosomes, Pages 63-92 Chapter 5 - Stem Cell Extracellular Vesicles: A Novel Cell-Based Therapy for Cardiovascular Diseases, Pages 93-117 Chapter 6 - Therapeutic Potential of Stem Cell-Derived Extracellular Vesicles in Cardioprotection and Myocardium Repair, Pages 119-138 Chapter 7 - Engineered/Hypoxia-Preconditioned MSC-Derived Exosome: Its Potential Therapeutic Applications, Pages 139-159 Chapter 8 - Exosome-Based Translational Nanomedicine: The Therapeutic Potential for Drug Delivery, Pages 161-176 Chapter 9 - Effect of Exosomes from Mesenchymal Stem Cells on Angiogenesis, Pages 177-205 Chapter 10 - Exosomes for Bone Diseases, Pages 207-221 Chapter 11 - Diagnostic and Prognostic Applications of MicroRNA-Abundant Circulating Exosomes, Pages 223-256 Subject Index, Pages 257-271 Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool.

• Introduces the MSC-exosome mediated cell-cell communication
• Covers the major functional benefits in current MSC-derived exosome studies
• Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies

"Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas--cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and looks toward the clinical applications of this exciting phenomenon, which is emerging as an effective diagnostic technique. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool."-- Page 4 of cover