Meiosis and Gametogenesis : Meiosis and Gametogenesis

In spite of the fact that the process of meiosis is fundamental to inheritance, surprisingly little is understood about how it actually occurs. There has recently been a flurry of research activity in this area and this volume summarizes the advances coming from this work. All authors are recognized and respected research scientists at the forefront of research in meiosis. Of particular interest is the emphasis in this volume on meiosis in the context of gametogenesis in higher eukaryotic organisms, backed up by chapters on meiotic mechanisms in other model organisms. The focus is on modern molecular and cytological techniques and how these have elucidated fundamental mechanisms of meiosis. Authors provide easy access to the literature for those who want to pursue topics in greater depth, but reviews are comprehensive so that this book may become a standard reference. Key Features* Comprehensive reviews that, taken together, provide up-to-date coverage of a rapidly moving field* Features new and unpublished information* Integrates research in diverse organisms to present an overview of common threads in mechanisms of meiosis* Includes thoughtful consideration of areas for future investigation Content: Editorial Board Page ii Edited by Page iii Copyright page Page iv Contributors Pages xi-xii Preface Pages xiii-xv Mary Ann Handel 1 Recombination in the Mammalian Germ Line Original Research Article Pages 1-35 Douglas L. Pittman, John C. Schimenti 2 Meiotic Recombination Hotspots: Shaping the Genome and Insights into Hypervariable Minisatellite DNA Change Original Research Article Pages 37-75 Wayne P. Wahls 3 Pairing Sites and the Role of Chromosome Pairing in Meiosis and Spermatogenesis in Male Drosophila Original Research Article Pages 77-115 Bruce D. McKee 4 Functions of DNA Repair Genes during Meiosis Original Research Article Pages 117-140 W. Jason Cummings, Miriam E. Zolan 5 Gene Expression during Mammalian Meiosis Original Research Article Pages 141-200 E.M. Eddy, Deborah A. O'Brien 6 Caught in the Act: Deducing Meiotic Function from Protein Immunolocalization Original Research Article Pages 201-218,218a,218b,218c,219-226,226a,228-239 Terry Ashley, Annemieke Plug 7 Chromosome Cores and Chromatin at Meiotic Prophase Original Research Article Pages 241-243,243a,245-246,246a,246b,247-251,251a,253-254,254a,256-262 Peter B. Moens, Ronald E. Pearlman, Henry H.Q. Heng 8 Chromosome Segregation during Meiosis: Building an Unambivalent Bivalent Original Research Article Pages 263-299 Daniel P. Moore, Terry L. Orr-Weaver 9 Regulation and Execution of Meiosis in Drosophila Males Original Research Article Pages 301-332 Jean Maines, Steven Wasserman 10 Sexual Dimorphism in the Regulation of Mammalian Meiosis Original Research Article Pages 333-358 Mary Ann Handel, John J. Eppig 11 Genetic Control of Mammalian Female Meiosis Original Research Article Pages 359-381 Patricia A. Hunt, Renée LeMaire-Adkins 12 Nondisjunction in the Human Male Original Research Article Pages 383-388,388a,389-390,390a,392-394,394a,396-398,398a,400-406 Terry J. Hassold Index Pages 407-418 In spite of the fact that the process of meiosis is fundamental to inheritance, surprisingly little is understood about how it actually occurs. There has recently been a flurry of research activity in this area and this volume summarizes the advances coming from this work. All authors are recognized and respected research scientists at the forefront of research in meiosis. Of particular interest is the emphasis in this volume on meiosis in the context of gametogenesis in higher eukaryotic organisms, backed up by chapters on meiotic mechanisms in other model organisms. The focus is on modern molecular and cytological techniques and how these have elucidated fundamental mechanisms of meiosis. Authors provide easy access to the literature for those who want to pursue topics in greater depth, but reviews are comprehensive so that this book may become a standard reference.

Key Features
* Comprehensive reviews that, taken together, provide up-to-date coverage of a rapidly moving field
* Features new and unpublished information
* Integrates research in diverse organisms to present an overview of common threads in mechanisms of meiosis
* Includes thoughtful consideration of areas for future investigation The process of meiosis is fundamental to inheritance. This volume places emphasis on meiosis in the context of gametogenesis in higher eukaryotic organisms, backed up by chapters on meiotic mechanisms in other model organisms. It focuses on modern molecular and cytological techniques and how these have elucidated fundamental mechanisms of meiosis Elucidation of meiotic recombination mechanisms in mammals faces many obstacles.