Medicinal Chemistry of Nucleic Acids (Wiley Series in Drug Discovery and Development)

« Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry-a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids-such as the new advances in genome sequencing, and the processes for creating RNA interference (RNAi) based drugs-to assist pharmaceutical researchers in removing roadblocks that hinder their ability to predict drug efficacy. Offering the latest cutting-edge science in this growing field, Medicinal Chemistry of Nucleic Acids includes: In-depth coverage of the development and application of modified nucleosides and nucleotides in medicinal chemistry. A close look at a large range of current topics on nucleic acid chemistry and biology. Essential information on the use of nucleic acid drugs to treat diseases like cancer. A thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research area. Thorough in its approach and promising in its message, Medicinal Chemistry of Nucleic Acids probes the new domains of pharmaceutical research-and exposes readers to a wealth of new drug discovery opportunities emerging in the dynamic field of nucleic acid chemistry. »-- Résumé de l'éditeur

Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology

Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids—such as the new advances in genome sequencing, and the processes for creating RNA interference (RNAi) based drugs—to assist pharmaceutical researchers in removing roadblocks that hinder their ability to predict drug efficacy. Offering the latest cutting-edge science in this growing field, Medicinal Chemistry of Nucleic Acids includes:

• In-depth coverage of the development and application of modified nucleosides and nucleotides in medicinal chemistry
  
  

• A close look at a large range of current topics on nucleic acid chemistry and biology
  
  

• Essential information on the use of nucleic acid drugs to treat diseases like cancer
  
  

• A thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research area
  
  

Thorough in its approach and promising in its message, Medicinal Chemistry of Nucleic Acids probes the new domains of pharmaceutical research—and exposes readers to a wealth of new drug discovery opportunities emerging in the dynamic field of nucleic acid chemistry.

BComplete, up-to-date coverage of the broad area of nucleic acid chemistry and biology/b Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, iMedicinal Chemistry of Nucleic Acids/i presents a thorough overview of nucleic acid chemistry'a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids'such as the new advances in genome sequencing, and the processes for creating RNA interference (RNAi) based drugs'to assist pharmaceutical researchers in removing roadblocks that hinder their ability to predict drug efficacy. Offering the latest cutting-edge science in this growing field, Medicinal Chemistry of Nucleic Acids includes:ulli In-depth coverage of the development and application of modified nucleosides and nucleotides in medicinal chemistryli A close look at a large range of current topics on nucleic acid chemistry and biologyli Essential information on the use of nucleic acid drugs to treat diseases like cancerli A thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research area/ul Thorough in its approach and promising in its message, iMedicinal Chemistry of Nucleic Acids/i probes the new domains of pharmaceutical research'and exposes readers to a wealth of new drug discovery opportunities emerging in the dynamic field of nucleic acid chemistry Cover......Page 1 Frontmatter......Page 2 Copyright © 2011......Page 5 Contents......Page 6 Foreword......Page 8 Contributors......Page 12 Introduction......Page 16 Colour Plates......Page 28 1 - RECENT ADVANCES IN CARBOCYCLIC NUCLEOSIDES: SYNTHESIS AND BIOLOGICAL ACTIVITY......Page 36 2 - STRUCTURES AND FUNCTIONS OF NUCLEIC ACIDS MODIFIED WITH S, Se, AND Te AND COMPLEXED WITH SMALL MOLECULES......Page 136 3 - UNRAVELING THE NAD CYCLIZING AND CALCIUM SIGNALING FUNCTIONS OF HUMAN CD38......Page 177 4 - DNA AND RNA BINDING SMALL MOLECULES......Page 199 5 - G-QUADRUPLEX DNA AND ITS LIGANDS IN ANTICANCER THERAPY......Page 241 6 - MOLECULAR MODELING IN NUCLEIC ACID-TARGETED DRUG DESIGN......Page 293 7 - STRUCTURE OF 10–23 DNAzyme IN COMPLEX WITH THE TARGET RNA IN SILICO - A PROGRESS REPORTON THE MECHANISM OF RNA CLEAVAGE BY DNA ENZYME......Page 307 8 - LABELING OLIGONUCLEOTIDES TOWARD THE BIOMEDICAL PROBE......Page 327 9 - LOCKED NUCLEIC ACID OLIGONUCLEOTIDES TOWARD CLINICAL APPLICATIONS......Page 370 10 - THE PHARMACOKINETICS RESEARCH OF NUCLEIC ACID DRUGS......Page 384 11 - INDUCIBLE RNAi AND DRUG TARGET VALIDATION......Page 425 12 - siRNA: THE SPECIFICITY AND OFF-TARGET EFFECTS......Page 440 INDEX......Page 458 Titles in Series......Page 464 Recent advances in carbocyclic nucleosides : synthesis and biological activity / Jianing Wang, Ravindra K. Rawal, and Chung K. Chu Structures and functions of nucleic acids modified with S, Se, and Teand complexed with small molecules / Wen Zhang, Jia Sheng, and Zhen Huang Unraveling of the NAD cyclizing and calcium signaling functions of human CD38 / Hon Cheung Lee DNA and RNA binding small molecules / Shibo Li and Zhen Xi G-quadruplex DNA and its ligands in anticancer therapy / Zhi-shu Huang ... [et al.] Molecular modeling in nucleic acid targeted drug design / Lidan Sun ... [et al.] Structure of 10-23 DNAzyme in complex with the target RNA in silico : a progress report on the mechanism of RNA cleavage by DNA enzyme / Oleksandr Plashkevych and Jyoti Chattopadhyaya Labeling oligonucleotides towards the biomedical probe / Il Joon Lee and Byeang Hyean Kim Locked nucleic acid oligonucleotides towards clinical application / Rakesh N. Veedu and Jesper Wengel The pharmacokinetics researches of nucleic acid drugs / Shengqi Wang Inducible RNAi and drug target validation / Wei Xiong ... [et al.] SiRNA : the specificity and off-target effects Quan Du, Huang Huang, Zicai Liang. Covering all areas of the medicinal chemistry and therapeutic applications of nucleic acids, this book provides up-to-date coverage of the broad area of nucleic acid chemistry and biology. The book lays out the basic principles of medicinal chemistry of nucleic acids before focusing on the development and application of modified nucleosides and nucleotides in medicinal chemistry. Cutting-edge subjects for drug discovery like antisense, RNAi, and siRNA are also discussed, and help the target audience of chemists, pharmaceutical researchers, and academics understand the use of nucleic acid drugs to treat diseases