Medicinal chemistry : chemistry and molecular aspects of drug design and action

An ever-increasing demand for better drugs, elevated safety standards, and economic considerations have all led to a dramatic paradigm shift in the way that drugs are being discovered and developed. Known as rational drug design, this contemporary process is defined by three main steps: the discovery of lead compounds, surgical manipulation to develop pharmacophores, and further optimization to produce the best compounds. Chemistry and Molecular Aspects of Drug Design and Action brings together an impressive collection of world-renowned pharmacochemistry scientists who are currently defining the emergence of rational drug design. Offering insight from their own specialized research, these pioneers highlight the variety of approaches being employed in this field, including those that start by considering either molecular mechanisms of drug action, or the metabolizing enzyme action occurring in the structure of a drug molecule. Another approach they explore is one that starts from the pathobiochemistry and pathophysiology of target diseases. Furthermore, the book also considers drug development that makes use of already developed compounds stored in data banks. Divided into five parts, each dedicated to various aspects of the classical medicinal chemistry approach, the text makes it easy for readers to focus on a field of specific interest. Chemical, Biochemical, and Biological Aspects of Pathophysiological Conditions Classical Medicinal Chemistry Drug Design, Chemical and Molecular Aspects of Drug Action Drug Xenobiotic Metabolism Physical Organic and Theoretical Medicinal Chemistry While each section can be studied independently, the combined material in this volume provides the most comprehensive overview available on rational drug design. This work is an invaluable resource both for those entering the field, as well as those researchers looking to build on current progress. Inflammatory mechanisms in Alzheimer's disease and other neurodegenerative disorders / J. Rogers ... [et al.] Treatment development strategies for Alzheimer's disease / E. Wülfert Lipoprotein-associated phospholipase A2 as a new prognostic factor for coronary artery disease / A. Tselepis Protein modifications by nitric oxide and reactive nitrogen species / H. Ischiropoulos Design, synthesis, and pharmacological evaluation of high affinity and selectivity sigma-1 and sigma-2 receptor ligands / J.H. Poupaert Synthesis of biologically active taxoids / K.C. Nicolaou and R.K. Guy From the molecular pharmacology to the medicinal chemistry of cannabinoids / D.M. Lambert New inhibitors of DNA topoisomerase in the treatment of experimental malignancies / C. Atassi Treatment of psoriasis with anthrones-biochemical aspects / W. Wiegrebe and K. Müller An appraisal of fomocaines, current situation, and outlook / H. Oelschläger and A. Seeling Ligands for the GABA recognition site at the GABAA receptor: structure-activity studies / B. Frølund ... [et al.] Discovery of potent and selective inhibitors of human aldosterone synthase (CYP11B2): a new target for the treatment of congestive heart failure and myocardial fibrosis: a review / R.W. Hartmann ... [et al.] Thiocarboxanilides: a new class of non-nucleoside reverse transcriptase inhibitors (NNRTIS) with great potential for the treatment of human immunodeficiency virus type 1 (HIV-1) infections / E. De Clercq, A. Karlsson, and J. Balzarini Histamine H3-receptor agonists and antagonists: chemical, pharmacological, and clinical aspects / H. Stark and W. Schunack Anti-inflammatory actions of flavonoids and structural requirements / T. Theoharides Molecular mechanisms of H2O2-induced DNA damage: the action of desferrioxamine / M. Tenopoulou, P.-T Doulias, and D. Galaris LNA (locked nucleic acid) and functionalized LNA: towards efficient gene targeting / J. Wengel The effect of diet on drug metabolism / K.J. Netter Cytochromes P450 in the metabolism and bioactivation of chemicals / C. Ioannides In vitro methods to measure drug metabolism and metabolic interactions in drug discovery and development / O. Pelkonen ... [et al.] How to probe the sites of action of drug molecules / A. Makriyannis and F. Bitter Lipophilicity as a descriptor of molecular properties in drug design / B. Testa ... [et al.] Drug membrane interaction and the importance for drug transport, distribution, accumulation, efficacy, and resistance / J.K. Seydel ... [et al.] Structure-based and computer-aided drug design / H. Kubinyi Physicochemical profiling in early drug discovery: new challenges at the age of high-throughput screen and combinatorial chemistry / B. Faller. Drawing from synthetic chemistry, molecular modelling, computational biology, structural genomics, and pharmacology, this text explores medicinal chemistry. It focuses on the correlation of properties and biological activity, and delves into the phenomenon of xenobiotic metabolism