Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes, Vol. 01

Springer Science + Business Media B.V. , 2008, 411 p. CARBON MATERIALS: CHEMISTRY AND PHYSICS A comprehensive book series which encompasses the complete coverage of carbon materials and carbon-rich molecules from elemental carbon dust in the interstellar medium to the most specialized industrial applications of elemental carbon and its derivatives. A great emphasis is placed on the most advanced and promising applications ranging from electronics to medicinal chemistry. The aim is to offer the reader a book series which not only consists of self-sufficient reference works, but one which stimulates further research and enthusiasm. Preface The emerging field of nanotechnology is affirming its increasing importance day by day. In this context fullerenes and carbon nanotubes (CNTs) play an important role. These new allotropic forms of carbon have been discovered in the last two decades, and, since then, they have stimulated the curiosity and interest of physicists and chemists. This book is the first of a new series entitled Carbon Materials: Chemistry and Physics, the purpose of which is to analyze the new frontiers of carbon. This volume summarizes the more recent advances on fullerenes and carbon nanotubes facing the biological-medical horizon, an important and interesting area to the scientific community. We will present general overviews of fullerenes and CNTs that are state-of-the-art in biomedical applications, deepening their principal and more promising exploitations. In particular for fullerenes, antioxidant properties and photodynamic activity are presented in detail, together with the analysis of gadolinium endohedrals as magnetic resonance imaging (MRI) contrast agents. Moreover, drug delivery based on carbon nanomaterials has been illustrated. Few chapters are dedicated to toxicity and to the use of nanomaterials as pollutant probes. The debate on fullerene and CNT toxicity is open and reports different results, which are not always able to abolish the concern about pollution related to the industrial production and their impact on the environment. However, it is possible to state that positive evidence for their favorable applications in medicine hasemerged. Theoretical calculation potentialities have been examined in few chapters, giving new instruments to predict fullerene solubility in different solvents, such as fatty acid esters. Visualization approaches necessary to study unusual compounds such as CNT are herein presented. Despite the structural novelty of CNT, its resemblance to cellular structures is highlighted, launching or confirming the hypothesis of using CNTs as communication devices between cells. Considering the specificity of the field, this book is mainly addressed to researchers who have delved, or who want to delve, into carbon nanoworld, but atthe same time, it presents a general and accurate view of carbon nanotechnology accessible to researchers intrigued by this topic, but not yet experts in the field. April 2008 Tatiana Da Ros Franco Cataldo

medicinal Chemistry And Pharmacological Potential Of Fullerenes And Carbon Nanotubes Features Important Insights Into The Applications Of Fullerenes And Carbon Nanotubes. It Discusses The Fullerene And Nanotubes Derivatives Which Are Effective Against Viruses, Cells, And Bacteria And Those Which Are Able To Interact And Inhibit Certain Enzymes. Also Covered In This Book Are The Formation Of Complex Structures Between Biologically Active Molecules And Carbon Materials. Furthermore, The Application Of Fullerenes In Certain Medical Therapies Is Explored, Including The Very Recent Discovery Of New Bio-compatible Media Which Could Be Used As Carriers In The Delivery Of Fullerenes In Vivo. An Additional Topic Of This Text Is The Formation Of Hybrids Between Nanotubes And Biological Molecules And Their Use As Chemical Sensors.

medicinal Chemistry And Pharmacological Potential Of Fullerenes And Carbon Nanotubes Will Be A Useful Tool Of Reference For Researchers, Postgraduates And Advanced Undergraduates In The Chemical, Biomedical, And Materials Sciences.

Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes features important insights into the applications of fullerenes and carbon nanotubes. It discusses the fullerene and nanotubes derivatives which are effective against viruses, cells, and bacteria and those which are able to interact and inhibit certain enzymes. Also covered in this book are the formation of complex structures between biologically active molecules and carbon materials. Furthermore, the application of fullerenes in certain medical therapies is explored, including the very recent discovery of new bio-compatible media which could be used as carriers in the delivery of fullerenes in vivo. An additional topic of this text is the formation of hybrids between nanotubes and biological molecules and their use as chemical sensors. Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes will be a useful tool of reference for researchers, postgraduates and advanced undergraduates in the Chemical, Biomedical, and Materials sciences Fullerenes and nanotubes are two classes of carbon structures or allotropes, which were discovered about 17 years ago. Since that time, many chemical derivatives have been synthesized using fullerenes and nanotubes as building blocks. Particularly promising was the theory that the chemical properties of fullerenes, and certain derivatives, made them likely candidates for anticancer drugs, inhibitors of viruses such as HIV, or even as anti-bacterials. Their cyctotoxicity can also be controlled by specific circumstances. In addition, the funtionalization of nanotubes has not only produced relatively simple derivatives, but also complex hybrids with biological macromolecules, which show unique supramolecular architecture and which are promising in many medical applications. The application of fullerenes and nanotubes in medicine is at the frontier of our knowledge, thus the work in this field represents the basis for future novel developments.