Medical Treatment of Glaucoma: The 7th Consensus Report of the World Glaucoma Association (Consensus Series)

'Medical Treatment of Glaucoma is the topic of the seventh World Glaucoma Association Consensus. Medical treatment of glaucoma continues to be at the core of glaucoma management. Hence, the results of this report will have broad and significant impact on glaucoma research and clinical practice. The global faculty, consisting of leading authorities on the clinical and scientific aspects of medical management, met in Fort Lauderdale on May 1, 2010 to discuss the reports and refine the consensus statements.'--Preface.

"Buzz Bissinger's Friday NightLights isan American classic. With The Mosquito Bowl, he is back with a true story even more colorful and profound. This book toois destined to become a classic. I devoured it." — John Grisham

An extraordinary, untold story of the Second World War in the vein of Unbroken and The Boys in the Boat, from the author of Friday Night Lights and Three Nights in August.

When the Japanese attacked Pearl Harbor, college football was at the height of its popularity.As the nation geared up for total war, one branch of the service dominated the aspirations of college football stars: the United States Marine Corps.Which is why, on Christmas Eve of 1944, when the 4th and 29th Marine regiments found themselves in the middle of the Pacific Ocean training for what would be the bloodiest battle of the war – the invasion of Okinawa—their ranks included one of the greatest pools of football talent ever assembled: Former All Americans, captains from Wisconsin and Brown and Notre Dame, and nearly twenty men who were either drafted or would ultimately play in the NFL.

When the trash-talking between the 4thand 29th over who had the better football team reached a fever pitch, it was decided: The two regiments would play each other in a football game as close to the real thing as you could get in the dirt and coral of Guadalcanal.The bruising and bloody game that followed became known as "The Mosquito Bowl."

Within a matter of months, 15 of the 65 players in "The Mosquito Bowl"would be killed at Okinawa, by far the largest number of American athletes ever to die in a single battle. The Mosquito Bowl is the story of these brave and beautiful young men, those who survived and those who did not.It is the story of the families and the landscape that shaped them. It is a story of a far more innocent time in both college athletics and the life of the country, and of the loss of that innocence.

Writing with the style and rigor that won him a Pulitzer Prize and have made several of his books modern classics, Buzz Bissinger takes us from the playing fields of America's campuses where boys played at being Marines, to the final time they were allowed to still be boys on that field of dirt and coral, to the darkest and deadliest days that followed at Okinawa.

PREFACE......Page 16 INTRODUCTION......Page 18 1. WHO SHOULD BE TREATED?......Page 20 2. TREATMENT GOALS. TARGET IOP*......Page 42 3. DRUGS......Page 48 I Cholingergic Agents......Page 50 II Beta-blockers......Page 56 III Alpha- and Beta-adrenergic Antagonists......Page 63 IV Alpha-adrenergic Agents......Page 78 V Prostaglandins......Page 93 VI Fixed-combination Preparations of IOP-lowering Agents inOpen-angle Glaucoma......Page 105 VII Investigational and Future Drugs......Page 124 VIII Preservatives in Topical Ophthalmic Medications......Page 129 IX Applying Pharmacogenomics to Improve Open-AngleGlaucoma Treatment Outcomes......Page 135 4. SELECTION OF DRUGS......Page 150 Initial therapy options......Page 151 Adjunctive therapy......Page 152 Surgery and medications......Page 157 5. MEDICAL TREATMENTS OF OTHER TYPESOF OPEN-ANGLE GLAUCOMA......Page 160 6. DRUG DELIVERY......Page 175 Adherence/Perseverance/Dyscompliance......Page 177 Delivery systems......Page 181 7. HEALTH ECONOMICS......Page 185 8. NON-PHARMACEUTICAL MEDICATIONSAND APPROACHES......Page 195 Quercetin and quercetin glycosides......Page 196 Methylcobalamin......Page 199 Curcumin......Page 201 Ginkgo biloba extract......Page 211 Grape seed extract......Page 215 Pycnogenol......Page 218 Fish oil and omega-3 fatty acids......Page 220 Alpha-lipoic acid......Page 224 Green tea......Page 228 Non-pharmaceutical approaches to the treatment of glaucomaCoffee, chocolate, and cocoa......Page 232 N-acetyl cysteine......Page 234 Citicoline......Page 238 Carnosine......Page 241 Carnitine......Page 242 Coenzyme Q10......Page 243 Folic acid......Page 244 Glutathione......Page 246 Melatonin......Page 247 Salvia miltiorrhiza......Page 248 Trifolium pratense (red clover)......Page 252 Bear bile......Page 254 Ginseng......Page 256 Wolfberry......Page 257 Bilberry......Page 261 Acupuncture and glaucoma......Page 262 Exercise......Page 268 Stress in glaucoma......Page 271 9. NEUROPROTECTION......Page 280 10. MEDICAL MANAGEMENT OF GLAUCOMAIN INFANTS AND CHILDREN......Page 285 11. TREATMENT OF GLAUCOMA INPREGNANCY......Page 292 12. UNMET NEEDS......Page 298 SUMMARY CONSENSUS POINTS......Page 305 DISCLOSURE CODES DEFINITIONS –CATEGORY CODE SPECIFIC FINANCIALINTERESTS:......Page 315 INDEX OF AUTHORS......Page 328