Mechanisms of secondary brain damage from trauma and ischemia : recent advances of our understanding : [proceedings of 7th International Symposium on Mechanisms of Secondary Brain Damage, Mauls, Italy

Top level clinical and laboratory scientists present their most recent clinical and experimental findings and concepts. The well balanced contributions illustrate the enormous significance of the dialogue between both laboratory and clinic, ultimately for the benefit of the patients, and contribute to a better understanding of secondary brain damage from trauma and ischemia as basis to develop more effective treatment including drugs. Front Matter....Pages I-VIII Front Matter....Pages 1-1 Knowledge matters....Pages 3-7 Gene profiling — chances and challenges....Pages 9-13 Role of mitochondrial proteins for neuronal cell death after focal cerebral ischemia....Pages 15-19 Signalling mechanisms for survival of lesioned motoneurons....Pages 21-35 Genetically modified animals in molecular stroke research....Pages 37-45 Front Matter....Pages 47-47 The Janus face of inflammation in ischemic brain injury....Pages 49-54 The natural course of lesion development in brain ischemia....Pages 55-61 Pharmacological preconditioning in global cerebral ischemia....Pages 63-66 Front Matter....Pages 67-67 The role of inflammatory processes in the pathophysiology and treatment of brain and spinal cord trauma....Pages 69-74 L-type calcium channel antagonist nifedipine reduces neurofilament restitution following traumatic optic nerve injury....Pages 75-80 Neuronal activity and cortical perfusion determined by quantitative EEG analysis and laser Doppler flowmetry are uncoupled in brain injured rats....Pages 81-85 Glial scar and axonal regeneration in the CNS: lessons from GFAP and vimentin transgenic mice....Pages 87-92 Front Matter....Pages 93-93 Recovery from spinal cord injury — underlying mechanisms and efficacy of rehabilitation....Pages 95-100 Lessons from epidemiologic studies in clinical trials of traumatic brain injury....Pages 101-107 The MRC CRASH trial — a large, simple randomised trial of steroids in head injury....Pages 109-112 Clinical trials in traumatic brain injury: current problems and future solutions....Pages 113-118 Prospective documentation and analysis of the pre- and early clinical management in severe head injury in Southern Bavaria at a population based level....Pages 119-123 Back Matter....Pages 125-132 Illustrates the significance of the dialogue between both laboratory and clinic, for the benefit of the patients. This work aims to contribute to a better understanding of secondary brain damage from trauma and ischemia as basis to develop more effective treatment, including drugs.