Mechanisms of Lymphocyte Activation and Immune Regulation XI: B Cell Biology (Advances in Experimental Medicine and Biology Book 596)

In recent years, major developments have been made in understanding various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires. These include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. A role and mechanism of DNA repair proteins in somatic hypermutation has been elucidated. Genetic mutation studies have been instrumental in providing insight into some of the mechanisms involved in targeting CSR to various switch DNA regions located upstream of C region genes, especially a role of AID motifs, transcription, and R-loops. Recent studies support a dominant role of receptor editing in central B cell tolerance and signaling pathways that regulate receptor editing in self-reactive and non-self-reactive immature B cells. These were some of the topics of discussion at the 11th International Conference on B cell Biology. These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity. B Cell Development And Immunoglobulin Gene Rearrangement. Regulation And Function Of The E2a Proteins In B Cell Development / Cornelis Murre. Multiple Roles For Blimp-1 In B And T Lymphocytes / David Savitsky [and Others] Memory B Cell Evolution: B Cell Biology / Louise J. Mcheyzer-williams And Michael G. Mcheyzer-williams. Bcr-linked Factors In Developmental Fate Decisions / Randall J. Brezski And John G. Monroe. Gene Regulatory Networks That Orchestrate The Development Of B Lymphocyte Precursors / Harinder Singh, Jagan M.r. Pongubala, And Kay L. Medina. Rules For The Rearrangement Events At The L Chain Gene Loci Of The Mouse / Fritz Melchers [and Others] Regulation Of Aid Function In Vivo / Reiko Shinkura [and Others] Targeting Of Aid To Immunoglobulin Genes / Ursula Storb [and Others] Targeting Aid To The Ig Genes / Ziqiang Li [and Others] Dna Replication To Aid Somatic Hypermutation / Zhenming Xu [and Others] -- Cell Signalling Recepton Editing Tolerance And Autoimmunity. Regulation Of Activation Induced Deaminase Via Phosphorylation / Uttiya Basu [and Others] Modulation Of Mhc Class Ii Signal Transduction By Cd19 / David M. Mills, John C. Stolpa, And John C. Cambier. Role Of Nf[kappa]b Signaling In Normal And Malignant B Cell Development / Yoshiteru Sasaki [and Others] Fc Receptor-like Proteins (fcrl): Immunomodulators Of B Cell Function / Götz R.a. Ehrhardt [and Others] Tolerance Mechanisms In The Late Phase Of The Antibody Response / Christopher C. Goodnow [and Others] Role Of Rs/[kappa]de In B Cell Receptor Editing / José Luis Vela And David Nemazee. The Regulation Of Receptor Editing / Mark S. Schlissel. B Cell Hyporesponsiveness And Autoimmunity: A New Paradigm / Christine Grimaldi [and Others]. Edited By Sudhir Gupta . . . [et Al.]. Proceedings From The 11th International Conference On B Cell Biology Held In Newport Beach, Ca, February 3-5 2006--t.p. Verso. Conference Was Previously Known As The International Conference On Mechanisms Of Lymphocyte Activation And Immune Regulation. Includes Bibliographical References And Index. Regulation and Function of the E2A Proteins in B Cell Development....Pages 1-7 Multiple Roles for Blimp-1 in B and T Lymphocytes....Pages 9-30 Memory B Cell Evolution: B Cell Biology....Pages 31-45 BCR-linked Factors in Developmental Fate Decisions....Pages 47-55 Gene Regulatory Networks that Orchestrate the Development of B Lymphocyte Precursors....Pages 57-62 Rules for the Rearrangement Events at the L Chain Gene Loci of the Mouse....Pages 63-70 Regulation of AID Function In Vivo ....Pages 71-81 Targeting of AID to Immunoglobulin Genes....Pages 83-91 Targeting AID to the Ig Genes....Pages 93-109 DNA Replication to Aid Somatic Hypermutation....Pages 111-127 Regulation of Activation Induced Deaminase via Phosphorylation....Pages 129-137 Modulation of MHC Class II Signal Transduction by CD19....Pages 139-148 Role of NFUPκB Signaling in Normal and Malignant B Cell Development....Pages 149-154 Fc Receptor–like Proteins (FCRL): Immunomodulators of B Cell Function....Pages 155-162 Tolerance Mechanisms in the Late Phase of the Antibody Response....Pages 163-168 Role of RS/κDE in B Cell Receptor Editing....Pages 169-172 The Regulation of Receptor Editing....Pages 173-179 B Cell Hyporesponsiveness and Autoimmunity: A New Paradigm....Pages 181-190 Ironically, the loss of Challenger in January 1986 fired my interest in space exploration more than any other single event. I was nine years old. My parents were, at the time, midway through moving house and, luckily, the TV was one of the few domestic items still to be packed. I watched the entire horror unfold live on all of the network stations. Admittedly, my fascination with rockets and astronauts, stars and planets had begun several years earlier, but Challenger's destruction turned it from an occasional hobby to a fascination which has remained with me ever since. In September 1988, aged 11,1 came home from school to watch STS-26 return the Shuttle fleet to orbital operations. Five years later, I gave a speech on the STS-51L disaster to my teacher as part of my GCSE English assessment. Another decade passed and, now a teacher myself, I returned to my school one cold Monday morning to explain to my pupils what had happened to Challenger's sister ship, Columbia, a few days earlier. In some ways, the loss of Columbia affected me more deeply than Challenger In recent years, major developments have increased understanding of various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires. These include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity.