Mechanisms of Lymphocyte Activation and Immune Regulation VII: Molecular Determinants of Microbial Immunity (Advances in Experimental Medicine and Biology Book 452)

The latest developments in the area of microbial immunity are explored and explained in this timely volume, including new conceptual frameworks for the processing and presentation of peptides and nonpeptide antigens from microbes to T cells. Such experimental models have been instrumental in defining some of the pathways for generating protective immune responses against microbes. Other topics covered include: DAP 12, CD4+, Th1 and Th2 Cells, HIV infection, fusion, and tropism, and vaccine development. Front Matter....Pages i-xi Front Matter....Pages 1-1 Development of Self-Recognition Systems in Natural Killer Cells....Pages 1-12 Activating and Inhibitory NK Cell Receptors....Pages 13-18 Regulation of Immune Responses by Inhibitory Receptors....Pages 19-28 Innate Functions of Epithelial γδ T Cells....Pages 29-35 Front Matter....Pages 37-37 Interleukin-4 Receptor Signalling Mechanisms and Their Biological Significance....Pages 37-43 Development of CD4+ Effector T Cells and Susceptibility to Infectious Diseases....Pages 45-52 Anti-Leishmania Effector Functions of CD4 + Th1 Cells and Early Events Instructing Th2 Cell Development and Susceptibility to Leishmania Major in BALB/c Mice....Pages 53-60 Genetic Control of the T Cell Response to Leishmania Major Infection....Pages 61-66 The Initiation and Function of Th2 Responses during Infection with Schistosoma Mansoni ....Pages 67-73 Front Matter....Pages 75-75 Interleukin-4 Production in Response to Infection with Intracellular Bacteria....Pages 75-83 Cytotoxic T Lymphocytes in Resistance to Tuberculosis....Pages 85-101 The Role of Dendritic Cells in the Initiation of Host Resistance to Toxoplasma Gondii ....Pages 103-110 Dynamics of the CD8+ T Cell Response during Acute LCMV Infection....Pages 111-122 In Vivo Dynamics of Anti-Viral CD8 T Cell Responses to Different Epitopes....Pages 123-142 Early Cytokine Responses to Viral Infections and Their Roles in Shaping Endogenous Cellular Immunity....Pages 143-149 Front Matter....Pages 151-151 HIV Entry and Tropism....Pages 151-157 Immune Control of HIV-1 Replication....Pages 159-167 HIV Transmission and Immune Protection at Mucosal Surfaces....Pages 169-175 The CD8 + T Lymphocyte Response during Primary SIVmac Infection....Pages 177-179 Front Matter....Pages 181-181 Non-Structural Determinants of Immunogenicity and the B Cell Co-Receptors, CD19, CD21, and CD22....Pages 181-186 Front Matter....Pages 181-181 DNA Vaccines....Pages 187-191 Vaccines Against the Blood Stages of Falciparum Malaria....Pages 193-205 Immunity to Pertussis....Pages 207-218 Back Matter....Pages 219-223 Proceedings of the Seventh International Conference held in New Port Beach, California, February 6-8, 1998