Mechanisms of Lymphocyte Activation and Immune Regulation IV: Cellular Communications (Advances in Experimental Medicine and Biology, 323)

In recent years rapid progress has been made in the areas of T cell and B cell biology, cell-cell and cell-matrix/stroma interactions. The use of isolated subunits of the T cell receptor invariant chains has been instrumental in defining their role in signal transduction and tyrosine phosphorylation. A role of src family phosphotyrosine kinases in T cell activation has been demonstrated and several phosphotyrosine kinase substrates have been identified and their functions characterized. Homologous recombinant techniques have led to the development of murine strains that lack CD4 or CD8 expression. These models are likely to be instrumental in studying the role of T cell subsets in autoimmune disorders, tissue transplant rejection and tumor rejection. A role of major histocompatibility complex I in the development of T cell subsets and NK cells has been defined. Recent data suggest a role of interaction between plasma membrane molecules of activated T helper cells and B cells, B cells primed with plasma membrane of activated T helper cells and cytokines, and interaction between bone marrow stromal cells and B cell progenitors and precursors, in the B cell development, proliferation, and differentiation. The structure and functions of adhesion molecules, especially with regard to signal transduction and homing events, are better defined. Front Matter....Pages i-ix Front Matter....Pages 1-1 T Cell Receptor Structure and Function: Analysis by Expression of Portions of Isolated Subunits....Pages 1-7 The T Cell Antigen Receptor Tyrosine Kinase Pathway....Pages 9-16 Dissection of the Hb(64–76) Determinant Reveals That the T Cell Receptor May Have the Capacity to Differentially Signal....Pages 17-21 CD28 Receptor Crosslinking Induces Tyrosine Phosphorylation of PLC γ1 ....Pages 23-27 Structure and Function of CD45: A Leukocyte-Specific Protein Tyrosine Phosphatase....Pages 29-37 Multidrug Resistant Gene 1 Product in Human T Cell Subsets: Role of Protein Kinase C Isoforms and Regulation by Cyclosporin A....Pages 39-47 Integrins, γδ T Cells, and Autoimmunity....Pages 49-55 The Interleukin-2 Receptor: A Target for Immunotherapy....Pages 57-66 Front Matter....Pages 67-67 Lymphocyte Development in Mice Deficient for MHC Class I Expression....Pages 67-72 Generation of Mutant Mice Lacking Surface Expression of CD4 or CD8 Gene Targeting....Pages 73-77 Alteration of T Cell Lineage Commitment by Expression of a Hybrid CD8/CD4 Transgene....Pages 79-87 Differential Involvement of Protein Tyrosine Kinases p56 lck and p59 fyn in T Cell Development....Pages 89-99 Mechanism of Tolerance Induction....Pages 101-109 Front Matter....Pages 111-111 B-Lymphocyte Lineage-Committed, IL-7 and Stroma Cell- Reactive Progenitors and Precursors, and Their Differentiation to B Cells....Pages 111-117 Regulatory Cells and Cytokines Involved in Primary B Lymphocyte Production....Pages 119-123 The Role of IL-7 and Its Receptor in B-Cell Ontogeny....Pages 125-129 Role of Contact and Soluble Factors in the Growth and Differentiation of B Cells by Helper T Cells....Pages 131-138 B-Cell Activation Mediated by Interactions with Membranes from Helper T Cells....Pages 139-148 The Low Affinity IgE Fc Receptor (CD23) Participates in B Cell Activation....Pages 149-156 Front Matter....Pages 157-157 T Cell Adhesion Cascades: General Considerations and Illustration with CD31....Pages 157-162 Front Matter....Pages 157-157 Analyses of VLA-4 Structure and Function....Pages 163-170 On the Regulation of β2 Integrins....Pages 171-179 Leukocyte-Endothelial Cell Adhesion as an Active, Multi-Step Process: A Combinatorial Mechanism for Specificity and Diversity in Leukocyte Targeting....Pages 181-194 Back Matter....Pages 195-204 Section I.T cell receptors and T cell activation section II. T cell development section III. B cell development, activation, proliferation, and differentiation section IV. Adhesion molecules : structure, regulation and functions.