Mechanisms of cytotoxicity by NK cells: based on the Third International Workshop on NK Cells held at Meadow Brook Hall, Oakland University, Rochester, Michigan in May 1984

Mechanisms of Cytotoxicity by NK Cells is the resulting book of a workshop focused on the studies that enhance understanding of the basic mechanisms involved in the function and regulation of NK cells. The book presents the status of knowledge of the mechanisms responsible for the cytotoxic effects of NK cells and the regulation of their activity. The text is further divided into five major sections according to the sequence of the workshop sessions. A separate chapter from the sections has been included at the beginning of the book. The introductory chapter clarifies some points in the subject area of NK cells, particularly its definition. The heterogeneity of NK cells is also discussed in this chapter. Then, the book presents the major topics, including the purification and characterization of NK cells and NK target structures and recognition sites. The mechanisms of postrecognition interactions between NK cells and targets; regulation of NK activity and NK cells; and cultured cells with NK-like activity are also discussed. This book will serve as a helpful guide to students and professionals (scientists, researchers, and professors) in the fields of immunology, biology, microbiology, biochemistry, among others. Content: Front Matter , Page iii Copyright , Page iv Contributors , Pages xiii-xix Preface , Pages xxi-xxiii , DENIS M. CALLEWAERT, RONALD B. HERBERMAN PURIFICATION AND CHARACTERIZATION OF NK CELLS , Pages 17-28 , Denis M. Callewaert SURFACE PHENOTYPE AND FUNCTIONS OF HUMAN NATURAL KILLER CELLS , Pages 29-38 , Giorgio Trinchieri, Gino Degliantoni, Michiko Kobayashi, Lucille London, Bice Perussia CHARACTERISTICS OF MOUSE NK CELLS AND THEIR PRECURSORS , Pages 39-47 , Sylvia B. Pollack ENRICHMENT METHODOLOGY FOR MURINE NK ACTIVITY , Pages 49-58 , T. Juhani Linna, Mahadev R. Patel MOLECULAR CHARACTERIZATION OF NK TARGET ANTIGENS AND TARGET RECOGNITION SITES ON NK CEILS , Pages 61-69 , Joseph Kaplan ANALYSIS OF NK TARGET STRUCTURES. K562 MEMBRANE COMPONENTS ASSOCIATED WITH SUSCEPTIBILITY TO NK ATTACK , Pages 71-80 , Dorothy Hudig, Lory Minning ROLE OF TARGET HISTOCOMPATIBILITY ANTIGENS IN REGULATION OF NATURAL KILLER ACTIVITY: A REEVALUATION AND A HYPOTHESIS , Pages 81-92 , Klas Kärre ROLE OF NK CELLS IN HYBRID RESISTANCE TO BONE MARROW GRAFTS , Pages 93-102 , Ichiro Nakamura, Claudio Bordignon, John P. Daley EVIDENCE THAT NATURAL KILLER CELLS ARE PRE-THYMIC T CELLS WITH RECEPTORS FOR SELF AND NON-SELF H ANTIGENS , Pages 103-115 , Joseph Kaplan RECEPTORS FOR “SELF” RECOGNITION SHARED BY HUMAN T LYMPHOCYTES AND NK CELLS , Pages 117-124 , M. Schlesinger, E.J. Margalioth, J.G. Bekesi Analysis of NK Activity Against Virus-Infected Target Cells , Pages 125-134 , Carlos Lopez, Patricia A. Fitzgerald, Thomas E. Schindler BIOCHEMISTRY OF NK CYTOTOXICITY , Pages 137-153 , Ronald H. Goldfarb NK-TARGET CELL INTERACTIONS IN BINDING, TRIGGERING, PROGRAMMING, AND LETHAL HIT STAGES OF NK CYTOTOXICITY , Pages 155-172 , Stephan R. Targan, Richard L. Deem NK MEDIATED CELL LYSIS: A DIRECTED SECRETORY EVENT OF CYTOLYTIC TUBULAR STRUCTURES , Pages 173-184 , Gunther Dennert, Abraham Kupfer, J.S. Singer INVOLVEMENT OF THE CYTOSKELETON AND AN ASSOCIATED 95 KD PROTEIN IN RECOGNITION AND LYSIS BY NK CELLS , Pages 185-194 , Eero Saksela, Olli Carpén, Ismo Virtanen ULTRASTRUCTURAL ANALYSIS OF HUMAN NATURAL KILLER CELL - TARGET CELL INTERACTIONS LEADING TO TARGET CELL LYSIS , Pages 195-204 , John C. Hiserodt, Theodore F. Beals ROLE OF PROTEASES IN NK ACTIVITY , Pages 205-212 , Ronald H. Goldfarb ENZYMES INVOLVED IN NATURAL KILLER CELL ACTIVITY: EVIDENCE FOR PHOSPHOLIPASES, LIPOXYGENASES, AND SERINE DEPENDENT PROTEINASES , Pages 213-222 , Dorothy Hudig, Doug Redelman, Kathleen Carine, Lory Minning THE ROLE OF PHOSPHOLIPID METHYLATION AND CHROMOSOMALLY REGULATED TARGET STRUCTURES IN PRE– AND POST–RECOGNITION EVENTS IN THE NK CYTOLYTIC PATHWAY , Pages 223-230 , Robert J. Lauzon, Tatsuo Kiyohara, John C. Roder MONOSACCHARIDE CONCENTRATION DEPENDENT INHIBITION OF HUMAN NATURAL CYTOTOXICITY , Pages 231-243 , E.W. Ades, M. Culwell, A. Hinson THE POTENTIAL ROLE OF ARACHIDONIC ACID METABOLISM IN NATURAL KILLER CELL ACTIVITY , Pages 245-252 , William E. Seaman, Janet Woodcock, Colin G. Brooks THE ROLE OF THE LIPOXYGENASE IN REGULATION OF NK ACTIVITY , Pages 253-261 , Kam H. Leung, Margot M. Ip, Hillel S. Koren NO CONFIRMED BOLE FOR REACTIVE OXYGEN INTERMEDIATES IN NATURAL KILLER (NK) CELL-MEDIATED CYTOLYSIS , Pages 263-286 , H. David Kay, Ronald H. Goldfarb, Elizabeth A. Wayner, Colin G. Brooks OXIDATIVE BURST DOES NOT MEDIATE HUMAN MONOCYTE TUMORICIDAL ACTIVITY , Pages 287-304 , Allen R. Chen, Hillel S. Koren THE ROLE OF CYTOPLASM1C GRANULES IN NK CELL CYTOTOXICITY , Pages 305-322 , Pierre Henkart, Maryanna Henkart, Paul Millard, Robert Blumenthal, Craig W. Reynolds FUNCTIONAL AND BIOCHEMICAL CHARACTERIZATION OF NATURAL KILLER CYTOTOXIC FACTORS AND THEIR ROLE IN THE NK LYTIC MECHANISM , Pages 323-333 , Susan C. Wright, Stanley M. Wilbur, Benjamin Bonavida CHARACTERISTICS OF HUMAN NATURAL KILLER CYTOTOXIC FACTOR (NKCF) LYSIS AND POSSIBLE RELATIONSHIP TO LYSIS BY NK CELLS , Pages 335-350 , John R. Ortaldo, Isaac Blanca, Ronald B. Herberman Role of Soluble Lytic Factors in NK Activity , Pages 351-360 , William H. Chambers, James T. Forbes, Thomas N. Oeltmann CYTOTOXIC FACTORS FROM MARMOSET MONKEY NK-LIKE CELL LINES , Pages 361-370 , Donald R. Johnson REGULATION OF NK CELLS , Pages 373-379 , Hillel S. Koren KINETIC MODELS FOR NATURAL CYTOTOXICITY AND THEIR USE FOR STUDYING ACTIVATED NK CELLS , Pages 381-395 , Denis M. Callewaert, Norma H. Mahle Augmentation of Natural Killer Cell Activity by Recombinant Interleukin-2 and Recombinant Interferons , Pages 397-407 , Michael J. Brunda, Viveca Davatelis LYMPHOKINES INVOLVED IN THE GENERATION AND REGULATION OF NK AND NC CELLS , Pages 409-420 , Edmund C. Lattime, Stuart Macphail, Osias Stutman REGULATION OF MOUSE NK ACTIVITY , Pages 421-431 , Carlo Riccardi, Graziella Migliorati, Antonio Giampietri, Emira Ayroldi, Ronald B. Herberman ALTERATIONS IN NUMBERS OF LGLs AS IMPORTANT COMPONENT OF IN VIVO REGULATION OF NK ACTIVITY , Pages 433-442 , Angela Santoni, Mario Piccoli, Guido Forni, Ronald B. Herberman, Luigi Frati EFFECTS OF PHORBOL ESTERS ON NK ACTIVITY , Pages 443-452 , Eva Klein, Maria-Grazia Masucci, Oscar Ramos CHARACTERIZATION OF SOLUBLE SUPPRESSOR FACTORS PRODUCED BY UNSTIMULATED NORMAL HUMAN LYMPHOCYTES , Pages 453-464 , Stanley A. Schwartz, Madhavan P.N. Nair ROLE OF TRANSFERRIN AND TRANSFERRIN-RELATED PROTEINS IN REGULATION OF NK ACTIVITY IN VITRO , Pages 465-476 , H. David Kay, Howard T. Petrie, Philip J. Bierman, Lynell W. Klassen EFFECT OF UVR AND MEMBRANE FLUIDITY ON NK CYTOTOXIC ACTIVITY , Pages 477-488 , Benjamin Bonavida, Monica Weitzen, Robert C. Roozemond IMMUNOREGULATORY EFFECTS OF NK CELLS , Pages 489-498 , Katsuo Kumagai, Ryuji Suzuki, Satsuki Suzuki, Sumio Arai REGULATION OF THE B CELL RESPONSE BY NK CELLS , Pages 499-506 , Claire P. Robles, Peter Pereira, Pascale Wortley, Sylvia B. Pollack DEFECTIVE NK CELL MECHANISM IN PATIENTS WITH LEUKEMIA , Pages 507-519 , E. Lotzová, C.A. Savary, M.J. Keating, J.P. Hester CHARACTERIZATION OF NK CELLS IN PATIENTS WITH CHRONIC MYELOGENOUS LEUKEMIA , Pages 521-528 , Yoshiaki Fujimiya, Paul K. Pattengale NATURAL KILLER CELL ACTIVITY IN GENETIC DISEASES , Pages 529-540 , Hugh F. Pross, Jerome A. Werkmeister NK CLONES: ISOLATION AND CHARACTERIZATIONS , Pages 543-562 , Reinder L.H. Bolhuis K562 TUMOR CELLS PREFERENTIALLY ACTIVATE LEU 11+ HUMAN LARGE GRANULAR LYMPHOCYTES IN A MIXED LYMPHOCYTE RESPONSE CULTURE , Pages 563-587 , Joseph H. Phillips, Lewis L. Lanier DISCRIMINATION BETWEEN ANOMALOUS KILLER CELLS AND NK-LIKE CELLS , Pages 589-597 , Gordon F. Burns, Tony Triglia, Jerome A. Werkmeister DIFFERENTIATION OF LARGE GRANULAR LYMPHOCYTES DURING INDUCTION OF ACTIVATED KILLER CELLS IN VITRO , Pages 599-606 , Tuomo Timonen PATTERNS OF PROLIFERATION IN HUMAN NK CELLS: PRACTICAL AND THEORETICAL IMPLICATIONS , Pages 607-616 , William W. Travis, Hillel S. Koren CULTURE OF NK CELLS: SPECIFICITY, PHENOTYPES, FUNCTIONS AND COMPARISON WITH ACTIVATED T CELLS , Pages 617-629 , John R. Ortaldo, Paola Allavena, Llewellyn Mason, Ronald B. Herberman ANALYSIS AND FUNCTIONAL CHARACTERIZATION OF T3 − , NK CELL DERIVED AND T3 + , CTL PRECURSOR CELL DERIVED CLONES , Pages 631-643 , R.J. van de Griend, R.L.H. Bolhuis NK CELLS AND T CELL DIFFERENTIATION , Pages 645-654 , Colin G. Brooks RECOGNITIVE HETEROGENEITY OF NK CELLS , Pages 655-664 , Graham Pawelec, Peter Wernet, Walter Newman INDEX , Pages 665-669