Mechanically Gated Channels and their Regulation (Mechanosensitivity in Cells and Tissues Book 6)

The volume dwells on the major issues of mechanical stress influencing the ion channels and intracellular signaling pathways. This book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. In our opinion the book presents not only the latest achievements in the field but also brings the problem closer to the experts in related medical and biological sciences as well as practicing doctors. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different living organs and tissues and allows to predict changes, which arise due to alterations of their environment, and possibly will allow to develop new methods of artificial intervention. We also hope that presenting the problem will attract more attention to it both from researchers and practitioners and will assist to efficiently introduce it into the practical medicine. Front Matter....Pages 1-1 Force from Lipids: A Multidisciplinary Approach to Study Bacterial Mechanosensitive Ion Channels....Pages 1-33 Mechanosensitive K2P channels, TREKking through the autonomic nervous system....Pages 35-68 TRPV1 in Cell Signaling: Molecular Mechanisms of Function and Modulation....Pages 69-102 The Molecular Mechanism of Multifunctional Mechano-Gated Channel TRPV4....Pages 103-157 Mechanical Stretch and Intermediate-Conductance Ca 2+ -Activated K + Channels in Arterial Smooth Muscle Cells....Pages 159-187 Sensing Mechanism of Stretch Activated Ion Channels....Pages 189-213 Ion Channels in Cardiac Fibroblasts: Link to Mechanically Gated Channels and their Regulation....Pages 215-244 The Role of Nitric Oxide in the Regulation of Ion Channels in the Cardiomyocytes: Link to Mechanically Gated Channels....Pages 245-262 The Role of Ion Channels in Cellular Mechanotransduction of Hydrostatic Pressure....Pages 263-279 Lipid-Mediated Mechanisms Involved in the Mechanical Activation of TRPC6 and TRPV4 Channels in the Vascular Tone Regulation....Pages 281-301 Stretch Effects on Atrial Conduction: A Potential Contributor to Arrhythmogenesis....Pages 303-325 Early Activation of Intracellular Signals after Myocardial Stretch: Anrep Effect, Myocardial Hypertrophy and Heart Failure....Pages 327-365 Recent Aspects of Angiotensin II Action in the Heart. Implications for Myocardial Ischemia and Heart Failure....Pages 367-378 Mechanosensitivity of Pancreatic β-cells, Adipocytes, and Skeletal Muscle Cells: The Therapeutic Targets of Metabolic Syndrome....Pages 379-404 The Role of the Primary Cilium in Chondrocyte Response to Mechanical Loading....Pages 405-426 Back Matter....Pages 420-420