McDonald's Blood Flow in Arteries, Sixth Edition: Theoretical, Experimental and Clinical Principles

For over fifty years, **McDonald's Blood Flow in Arteries** has remained the definitive reference work in the field of arterial hemodynamics, including arterial structure and function with special emphasis on pulsatile flow and pressure. Prestigious, authoritative and comprehensive, the sixth edition has been totally updated and revised with several new chapters. This edition continues to provide the theoretical basis required for a thorough understanding of arterial blood flow in both normal and pathological conditions, while keeping clinical considerations and readability paramount throughout the text.New for the sixth edition * McDonald's groundbreaking waveform analysis is extended to explain ill effects of aging on the aorta and heart, and on the small blood vessels of vital organs - brain and kidneys. * Rigorous theory and methodology are combined to show relevance of blood pressure and flow pulsations to individual clinical problems and to results of the most recent epidemiological studies and clinical trials. * Written by a small tightly-knit group to provide consistency and easy reference of normal and abnormal functions in arteries of all sizes in humans, experimental animals, and realistic computer models. * Now available in a digital version, together with this book, to provide instant access to this invaluable reference resource. Erudite, definitive yet thoroughly practical, **McDonald's Blood Flow in Arteries** is essential reading for modern cardiologists, intensive care physicians, anesthesiologists, gerontologists, diabetologists, nephrologists and neurologists as well as physiologists, pharmacologists and epidemiologists. Book title......Page 4 Contents......Page 8 Foreword......Page 10 Foreword......Page 11 Preface......Page 12 List of Abbreviations......Page 14 1 Introduction......Page 16 2 The nature of flow of a liquid......Page 28 3 Properties of the arterial wall: theory......Page 70 4 Properties of the arterial wall: practice......Page 92 5 Endothelial function......Page 126 6 General principles for measuring arterial waves......Page 144 7 Pulsatile pressure–flow relations......Page 180 8 Ultrasound......Page 192 9 Wave reflections......Page 210 10 Contours of pressure and flow waves in arteries......Page 240 11 Principles of recording and analysis of arterial waveforms......Page 270 12 Vascular impedance......Page 288 13 Aortic input impedance as ventricular load......Page 326 14 Coupling of the left ventricle with the systemic circulation: implications to cardiac failure......Page 336 15 Cardiac failure: clinical implications......Page 360 16 The pulmonary circulation......Page 372 17 The coronary circulation......Page 390 18 Special circulations......Page 412 19 Aging......Page 426 20 Hypertension......Page 462 21 Interpretation of blood pressure in epidemiological studies and clinical trials......Page 484 22 Arterial biomarkers......Page 500 23 Atherosclerosis......Page 514 24 Specific arterial disease......Page 522 25 Generalized and metabolic disease......Page 538 26 Therapeutic strategies......Page 550 27 Exercise......Page 568 28 Central arterial pressure......Page 584 29 Lifestyle and environment......Page 594 30 Pressure pulse waveform analysis......Page 610 Bibliography......Page 654 A......Page 758 C......Page 760 E......Page 762 F......Page 763 I......Page 764 M......Page 765 P......Page 766 R......Page 767 S......Page 768 V......Page 769 Z......Page 770 For over fifty years, McDonald's Blood Flow in Arteries has remained the definitive reference work in the field of arterial hemodynamics, including arterial structure and function with special emphasis on pulsatile flow and pressure. Prestigious, authoritative and comprehensive, the sixth edition has been totally updated and revised with several new chapters. This edition continues to provide the theoretical basis required for a thorough understanding of arterial blood flow in both normal and pathological conditions, while keeping clinical considerations and readability paramount throughout the text. New for the sixth edition McDonald's groundbreaking waveform analysis is extended to explain ill effects of aging on the aorta and heart, and on the small blood vessels of vital organs - brain and kidneys. Rigorous theory and methodology are combined to show relevance of blood pressure and flow pulsations to individual clinical problems and to results of the most recent epidemiological studies and clinical trials. Written by a small tightly-knit group to provide consistency and easy reference of normal and abnormal functions in arteries of all sizes in humans, experimental animals, and realistic computer models. Now available in a digital version, together with this book, to provide instant access to this invaluable reference resource. Erudite, definitive yet thoroughly practical, McDonald's Blood Flow in Arteries is essential reading for modern cardiologists, intensive care physicians, anesthesiologists, gerontologists, diabetologists, nephrologists and neurologists as well as physiologists, pharmacologists and epidemiologists. This Book Is A Dedicated Resource For Those Sitting The Part A Of The Mcem (membership Of The College Of Emergency Medicine) Examination. It Forms An Essential Revision Guide For Emergency Trainees Who Need To Acquire A Broad Understanding Of The Basic Sciences, Which Underpin Their Approach To Clinical Problems In The Emergency Department. Common Clinical Scenarios Are Used To Highlight The Essential Underlying Basic Science Principles, Providing A Link Between Clinical Management And A Knowledge Of The Underlying Anatomical, Physiological, Pathological And Biochemical Processes. Multiple Choice Questions With Reasoned Answers Are Used To Confirm The Candidates Understanding And For Self Testing. Unlike Other Recent Revision Books Which Provide Mcq Questions With Extended Answers, This Book Uses Clinical Cases Linked To The Most Recent Basic Science Aspects Of The Cem Syllabus To Provide A Book That Not Only Serves As A Useful Revision Resource For The Part A Component Of The Mcem Examination, But Also A Unique Way Of Understanding The Processes Underlying Common Clinical Cases Seen Every Day In The Emergency Department. This Book Is Essential For Trainees Sitting The Part A Of The Mcem Exam And For Clinicians And Medical Students Who Need To Refresh Their Knowledge Of Basic Sciences Relevant To The Management Of Clinical Emergencies. 'McDonald's Blood Flow in Arteries' provides the theoretical basis required for the understanding of arterial blood flow, both in normal and in disease conditions including pulmonary hypertension, atherosclerosis and heart failure. Timed to publish in the year of the 50th anniversary of the first edition, this is a sixth edition of the key reference work in arterial haemodynamics.