Maturation phenomenon in cerebral ischemia II : neuronal recovery and plasticity ; with 14 tables

Many nerve cells of the brain which are not killed outright may suffer delayed death or recovery after ischemic insult. This fact has led to the concept of maturation phenomenon of neuronal injuries. Since the 1st International Symposium on Maturation Phenomenon in 1990, new developments, particularly in molecular biology, have been rapidly bringing new information about molecular nature and mechanisms of cell death. This book contains the presentations of the 2nd International Symposium held in Tokyo in April 1996. The latest developments in maturation phenomenon and the present status of investigation are described and further stimulation of research in this field is provided. The book contains black-and-white illustrations. Front Matter....Pages i-xiii Front Matter....Pages 223-225 Molecular Approaches to Neuronal Functions and Neuronal Cell Death....Pages 3-9 Evolution of Gene Expression in Hippocampus Following Focal and Global Ischemia....Pages 11-17 Synaptic Messengers, Inflammatory Mediators, and Neuronal Plasticity in Cerebral Ischemia....Pages 19-25 Ischemic Neuronal Injury and Gene Expression of Facilitative and Inhibitory Growth Factors....Pages 27-32 Is Apoptosis Involved in Glutamate Neurotoxicity?....Pages 33-40 Front Matter....Pages 41-41 Glutamate Enhances Brain Damage from Ischemia and Trauma....Pages 43-51 Glutamate-Mediated Mechanisms in Delayed Neuronal Death After Cerebral Ischemia....Pages 53-56 Neuroprotection by Drug-Induced Neurotrophic Factors....Pages 57-67 Stress Response and Ischemic Tolerance in the Brain....Pages 69-75 Preconditioning Depresses Excitatory Cell Signaling Following the Second Ischemic Insult....Pages 77-84 Electrophysiological Evaluation of Ischemic Tolerance Phenomenon....Pages 85-91 Transient Ischemia Depletes Free Ubiquitin in the Gerbil Hippocampal CA1 Neurons....Pages 93-97 Insight into the Protective Mechanisms of Cortical Spreading Depression in Cardiac Arrest Cerebral Ischemia in Rat....Pages 99-104 Transneuronal Induction of Tolerance in Cerebral Ischemia....Pages 105-111 Front Matter....Pages 113-113 Features and Threshold of Infarct Development in Ischemic Maturation Phenomenon....Pages 115-121 Impending Cerebral Infarction and Inflammatory Response: A Possible Target for Therapeutic Intervention....Pages 123-127 Astroglial and Microglial Activation in Hippocampus of Rat After Global Forebrain Ischemia....Pages 129-142 Glial Protection Against Neuronal Damage....Pages 143-150 On the Role of Glia-Derived Protease Nexin-1 in Neuronal and Glial Adaptation to Ischemia-Induced Cell Loss in Human Brain....Pages 151-158 Functional Outcome After Brain Infarction: Effect of Enriched Environment and Amphetamine....Pages 159-167 Front Matter....Pages 113-113 Behavioral Changes After Cerebral Infarction in the Rat: Long-Term Spatial Cognitive Impairment and Cerebral Acetylcholine Levels....Pages 169-175 Modulation of Protein Synthesis and Calcium Uptake Following Traumatic Lesion of Rat Brain Cortex....Pages 177-182 Temperature Modulation in the Ischemic Maturation Phenomenon....Pages 183-188 The Role of Endothelin-1 and Nitric Oxide in Cerebral Ischemia....Pages 189-195 Microglial Cell Death Following Phagocytosis of Zymosan-A Under a Video-Enhanced Contrast — Differential Interference Contrast Microscope: Does This Include Apoptosis?....Pages 197-203 Mitochondrial Respiratory Enzyme Activity and the Maturation Phenomenon in Cerebral Ischemia....Pages 205-211 Maturation of Cell Damage After Repetitive Hypoxia—Ischemia in the Rat....Pages 213-217 Synopsis and Round Table Discussion....Pages 219-221 Back Matter....Pages 223-225