Matrix Proteases in Health and Disease: BEHRENDT:MATRIX PROTEASES O-BK

Presenting a comprehensive overview of the multifaceted field of proteases in the extracellular matrix environment, this reference focuses on the recently elucidated functions of complex proteolytic systems in physiological and pathological tissue remodeling. The proteases treated include both serine proteases such as plasminogen activators and TTSPs, metalloproteases such as MMPs and ADAMS and cysteine protease cathepsins. The text specifically addresses the role of extracellular proteases in cancer cell invasion, stroke and infectious diseases, describing the basic biochemistry behind these disease states, as well as therapeutic strategies based on protease inhibition. With its trans-disciplinary scope, this reference bridges the gap between fundamental research and biomedical and pharmaceutical application, making this required reading for basic and applied scientists in the molecular life sciences.Content: Chapter 1 Matrix Proteases and the Degradome (pages 5–23): Clara Soria?Valles, Carlos Lopez?Otin and Ana Gutierrez?Fernandez Chapter 2 The Plasminogen Activation System in Normal Tissue Remodeling (pages 25–55): Vincent Ellis Chapter 3 Physiological Functions of Membrane?Type Metalloproteases (pages 57–78): Kenn Holmbeck Chapter 4 Bone Remodeling: Cathepsin K in Collagen Turnover (pages 79–97): Dieter Bromme Chapter 5 Type?II Transmembrane Serine Proteases: Physiological Functions and Pathological Aspects (pages 99–125): Gregory S. Miller, Gina L. Zoratti and Karin List Chapter 6 Plasminogen Activators in Ischemic Stroke (pages 127–156): Gerald Schielke and Daniel A. Lawrence Chapter 7 Bacterial Abuse of Mammalian Extracellular Proteases during Tissue Invasion and Infection (pages 157–180): Claudia Weber, Heiko Herwald and Sven Hammerschmidt Chapter 8 Experimental Approaches for Understanding the Role of Matrix Metalloproteinases in Cancer Invasion (pages 181–226): Elena Deryugina Chapter 9 Plasminogen Activators and Their Inhibitors in Cancer (pages 227–249): Joerg Hendrik Leupold and Heike Allgayer Chapter 10 Protease Nexin?1 – a Serpin with a Possible Proinvasive Role in Cancer (pages 251–281): Tina M. Kousted, Jan K. Jensen, Shan Gao and Peter A. Andreasen Chapter 11 Secreted Cysteine Cathepsins – Versatile Players in Extracellular Proteolysis (pages 283–297): Fee Werner, Kathrin Sachse and Thomas Reinheckel Chapter 12 ADAMs in Cancer (pages 299–324): Dorte Stautz, Sarah Louise Dombernowsky and Marie Kveiborg Chapter 13 Urokinase?Type Plasminogen Activator, Its Receptor and Inhibitor as Biomarkers in Cancer (pages 325–344): Tine Thurison, Ida K. Lund, Martin Illemann, Ib J. Christensen and Gunilla Hoyer?Hansen Chapter 14 Clinical Relevance of MMP and TIMP Measurements in Cancer Tissue (pages 345–371): Omer Bashir, Jian Cao and Stanley Zucker Chapter 15 New Prospects for Matrix Metalloproteinase Targeting in Cancer Therapy (pages 373–387): Emilie Buache and Marie?Christine Rio

Presenting a comprehensive overview of the multifaceted field of proteases in the extracellular matrix environment, this reference focuses on the recently elucidated functions of complex proteolytic systems in physiological and pathological tissue remodeling. The proteases treated include both serine proteases such as plasminogen activators and TTSPs, metalloproteases such as MMPs and ADAMS and cysteine protease cathepsins. The text specifically addresses the role of extracellular proteases in cancer cell invasion, stroke and infectious diseases, describing the basic biochemistry behind these disease states, as well as therapeutic strategies based on protease inhibition.

With its trans-disciplinary scope, this reference bridges the gap between fundamental research and biomedical and pharmaceutical application, making this required reading for basic and applied scientists in the molecular life sciences.