Matrix Metalloproteinase Inhibitors in Cancer Therapy (Cancer Drug Discovery and Development)

Cutting-edge investigators review the current status of the entire field, from the biology of MMPs through the current clinical studies. The authors include many leading scientists from pharmaceutical companies who present all the latest concepts and results on the preferred design strategies for MMP inhibitors, their molecular mechanisms, and their substrates. In addition, they fully describe their personal research on specific MMP inhibitors, detailing vanguard design strategies, their in vitro activity, the outcome of animal model studies and, where available, their toxicology, safety, efficacy in human clinical trials. Comprehensive and state-of-the-art, Matrix Metalloproteinase Inhibitors in Cancer Therapy offers basic and clinical investigators alike a richly informative summary of all the latest research on these powerful new drugs, and their high promise as emerging cancer therapeutics.

the Association Of Matrix Metalloproteinases (mmps)-enzymes That Disrupt The Body's Normal Repair Functions-with Several Diseases, Including Growing And Invasive Tumors, Holds The Tantalizing Promise That Their Inhibiton Might Have Therapeutic Value. In Matrix Metalloproteinase Inhibitors In Cancer Therapy, Cutting-edge Investigators Review The Current Status Of The Entire Field, From The Biology Of Mmps Through The Current Clinical Studies. The Authors Include Many Leading Scientists From Pharmaceutical Companies Who Present All The Latest Concepts And Results On The Preferred Design Strategies For Mmp Inhibitors, Their Molecular Mechanisms, And Their Substrates. In Addition, They Fully Describe Their Company's Research Effort On Specific Mmp Inhibitors, Detailing Vanguard Design Strategies, Their In Vitro Activity, The Outcome Of Animal Model Studies And, Where Available, Their Toxicology, Safety, And Efficacy In Human Clinical Trials. Comprehensive And State-of-the-art, Matrix Metalloproteinase Inhibitors Offers Basic And Clinical Investigators Alike A Richly Informative Summary Of All The Latest Research On These Powerful New Drugs, And Their High Promise As Emerging Cancer Therapeutics.

eric M. Scholar

this Book Is The Latest In The Cancer Drug Discovery And Development Series. The Purpose Is To Provide An Informative Summary Of The Latest Research On The Matrix Metalloproteinase Inhibitors, A New Class Of Drugs. The Book Covers The Entire Field Of Metalloproteinase Inhibitors From The Biology Of These Compounds Through Current Clinical Studies And Is Written For Students, Basic Scientists And Clinicians. It Is Edited By Neil Clendeninn And Krzysztof Appelt And The Contributors Include Leading Scientists From Pharmaceutical Companies. In The First Half Of The Book The Authors Discuss The Molecular Mechanisms Of The Enzymes, Substrates And Natural Inhibitors As Well The Design Strategy For Mmp Inhibitors. There Are Chapters On The Biology And Regulation Of The Mmpis, Tissue Inhibitors Of Metalloproteinases, The Substrate Specificity Of The Enzyme And Mmpis Role In Cancer. Some Of The Chapters Also Discuss Uses Of Mmpis In Diseases Other Than Cancer. The Last Half Of The Book Consists Of Five Chapters That Review The Development Of These Drugs Within The Industry. Authors From Each Of Five Pharmaceutical Companies Present Their Research On These Drugs Including The Design Strategy, In Vitro Animal Work, Toxicology, And Human Clinical Trial Safety And Efficacy For Each Of Their Respective Mmp Inhibitors. Given The Importance And Rapid Expansion Of This Field This Is A Very Useful And Interesting Book. It Provides Up-to-date Information On Several Aspects Of This Area With Chapters Covering All The Important Areas. The Last Five Chapters Are Written By People From Companies Who May Potentially Market The Drugs Described So Their Material May Be Biased. However, This Is A Minordeficiency In An Otherwise Excellent Book.

Matrix metalloproteinases (MMPs) are the predominant family of enzymes that degrade extracellular matrix and cell surface molecules.