Mast Cells and Basophils: Development, Activation and Roles in Allergic/Autoimmune Disease: Novartis Foundation Symposium 271

The book presents recent advances relating to the factors and mechanisms that regulate the growth, differentiation and function of mast cells and basophils; discussion of new technologies used to study these cells, and integration of the basic scientific findings in the context of therapeutic possibilities for the treatment of diseases such as allergic inflammation and autoimmune disease which are mediated, in part, by these granulocytes.Content: The Book Covers Recent Advances Relating To The Factors And Mechanisms That Regulate The Growth, Differentiation And Function Of Mast Cells And Basophils. It Describes New Technologies Used To Study These Cells. It Also Discusses How The Basic Scientific Findings Can Be Integrated Into Possible Therapeutic Applications. The Book Focuses On The Role Of Mast Cells And Basophils In Disease. Some Of The Discussions Examine The Part Played By Mast Cells In Allergic Inflammation And The Effect Of Stabilization Of These Cells In Novel Therapies. There Is Also Discussion Of Mastocytosis And The Underlying Mutations.--jacket. Chair's Introductions / Santa Jeremy Ono -- Mitf And Sgigsf: An Essential Transcription Factor And Its Target Adhesion Molecule For Development And Survival Of Mast Cells / Yukihiko Kitamure -- Immune Sensitization In The Skin Is Enhanced By Antigen-independent Effects Of Ige On Mast Cells / Paul J. Bryce, Mendy L. Miller, Ichiro Miyajima, Mindy Tsai, Stephen J. Galli And Hans C. Oettgen -- The Role Of Src Family Kinases In Mast Cell Effector Function / Yasuko Furumoto, Gregorio Gomez, Claudia Gonzalez-espinosa, Martina Kovarova, Sandra Odom, John J. Ryan And Juan Rivera -- Rasgrp4 In Mast-cell Signalling And Disease Susceptibility / Richard L. Stevens, Nasa Morokawa, Jing Wang And Steven A. Krilis -- Regulation Of Mast Cell Secretory Response To The Type I Fce Receptor: Inhibitory Elements And Disensitisation / J. Abramson, E.a. Barbu And I. Pecht -- Ige Regulation Of Mast Cell Survival And Function / Toshiaki Kawakami, Jiro Kitaura, Wenbin Xiao And Yuko Kawakami --^ Rabgef1, A Negative Regulator Of Ras Signalling, Mast Cell Activation And Skin Inflammation / See-ying Tam, Janet Kalesnikoff, Susumu Nakae, Mindy Tsai -- Role Of Cc Chemokines And Their Receptors In Multiple Aspects Of Mast Cell Biology: Comparative Protein Profiling Of Fceri- And /or Ccr1-engaged Mast Cells Using Protein Chip Technology / Masako Toda, Takao Nakamura, Masaharu Ohbayashi, Yoshifumi Ikeda, Maria Dawson, Richardo Micheler Richardson, Andrew Alban, Benjamin Leed, Dai Miyazaki And Santa Jemy Ono -- The Role Of Phosphoinositide-3-kinase In Mast Cell Homing To The Gastrointestinal Tract / Shigeo Koyasu, Akiko Minowa, Yasuo Terauchi, Takashi Kadowaki And Satoshi Matsuda -- The Mast Cell And The Cysteinyl Leukotrienes / Frank Austen -- Regulation Of Gene Expression In Mast Cells: Micro-rna Expression And Chromatin Structural Analysis Of Cytokine Genes / Silvia Monticelli, K. Mark Ansel, Dong U. Lee And Anjana Rao --^ The Involvement Of Bcl-2 In Mast Cell Apoptosis / Cellina Cohen-saidon And Ehud Razin -- Mast Cells In Autoantibody Responses And Arthritis / P.a. Nigrovic And D.m. Lee -- Mastering The Immune Response: Mast Cells In Autoimmunity / Greg D. Gregory, Allison Bickford, Michaela Robbie-ryan, Mindy Tanzola And Melissa A. Browwn -- Mastocytosis / Dean D. Metcalfe. [editors, Gregory Bock And Jamie Goode]. Symposium On Mast Cells And Basophils : Development, Activation And Roles In Allergic/autoimmune Disease, Held At The Novartis Foundation, London, 16-18 November 2004--contents P. Includes Bibliographical References And Indexes. Addresses the research on mast cells and basophils and its significance in relation to allergic and autoimmune diseases. This is an area of burgeoning interest, driven by increasing recognition of the fundamental importance of these cell types in several disease processes.