Mast Cell Biology: Contemporary and Emerging Topics (Advances in Experimental Medicine and Biology, 716)

The editors of Mast Cell Biology, Drs. Gilfillan and Metcalfe, have enlisted an outstanding group of investigators to discuss the emerging concepts in mast cell biology with respect to development of these cells, their homeostasis, their activation, as well as their roles in maintaining health on the one hand and on the other, their participation in disease. Mast Cell Biology : Introduction And Overview / Alasdair M. Gilfillan, Sarah J. Austin, And Dean D. Metcalfe -- Mast Cell Progenitor Trafficking And Maturation / Jenny Hallgren And Michael F. Gurish -- Monomeric Ige And Mast Cell Development, Survival, And Function / Jun-ichi Kashiwakura, Iris M. Otani, And Toshiaki Kawakami -- Mast Cell Apoptosis And Survival / Maria Ekoff And Gunnar Nilsson -- Regulators Of Ca2+ Signaling In Mast Cells -- Potential Targets For Treatmen Of Mast Cellrelated Diseases / Hong-tao Ma And Michael A. Beaven -- Spatio-temporal Signaling In Mast Cells / Bridget S. Wilson, Janet M. Oliver, And Diane S. Lidke -- The Mechanisms Of Exocytosis In Mast Cells / Ulrich Blank -- An Emerging Role For The Lipid Mediator Sphingosine-1-phosphate In Mast Cell Effector Function And Allergic Disease / Ana Olivera And Juan Rivera. Down-regulation Of Mast Cell Responses Through Itim Containing Inhibitory Receptors / Laila Karra And Francesca Levi-schaffer -- The Mast Cell In Innate And Adaptive Immunity / Christopher P. Shelburne And Soman N. Abraham -- Mast Cells And Immunoregulation/immunomodulation / Mindy Tsai, Michele Grimbaldeston, And Stephen J. Galli -- Mast Cell Proteases As Protective And Inflammatory Mediators / George H. Caughey -- Mast Cells In Lung Inflammation / Elena P. Moiseeva And Peter Bradding -- Mast Cells, Angiogenesis, And Cancer / Domenico Ribatti And Enrico Crivellato. Edited By Alasdair M. Gilfillan, Dean D. Metcalfe. Includes Bibliographical References And Index. Front Matter....Pages i-xxiii Front Matter....Pages 1-1 Mast Cell Biology: Introduction and Overview....Pages 2-12 Front Matter....Pages 13-13 Mast Cell Progenitor Trafficking and Maturation....Pages 14-28 Monomeric IgE and Mast Cell Development, Survival and Function....Pages 29-46 Mast Cell Apoptosis and Survival....Pages 47-60 Front Matter....Pages 61-61 Regulators of Ca 2+ Signaling in Mast Cells: Potential Targets for Treatment of Mast Cell-Related Diseases?....Pages 62-90 Spatio-Temporal Signaling in Mast Cells....Pages 91-106 The Mechanisms of Exocytosis in Mast Cells....Pages 107-122 An Emerging Role for the Lipid Mediator Sphingosine-1-Phosphate in Mast Cell Effector Function and Allergic Disease....Pages 123-142 Down-Regulation of Mast Cell Responses through ITIM Containing Inhibitory Receptors....Pages 143-159 Front Matter....Pages 161-161 The Mast Cell in Innate and Adaptive Immunity....Pages 162-185 Mast Cells and Immunoregulation/Immunomodulation....Pages 186-211 Mast Cell Proteases as Protective and Inflammatory Mediators....Pages 212-234 Mast Cells in Lung Inflammation....Pages 235-269 Mast Cells, Angiogenesis and Cancer....Pages 270-288 Back Matter....Pages 289-294