Married To The Office Slut: Parts 1-6

This is a cleaned version with correct pagination as well as without missing pages. It is also the same format as the hardcover version of the book, and not converted from .epub. Cover......Page 1 Title Page......Page 4 Copyright Page......Page 5 Contents......Page 8 Contributors......Page 10 Preface......Page 16 Acknowledgments......Page 18 Section I: General Principles......Page 20 1. Drug Invention and the Pharmaceutical Industry......Page 22 2. Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination......Page 32 3. Pharmacodynamics: Molecular Mechanisms of Drug Action......Page 50 4. Drug Toxicity and Poisoning......Page 74 5. Membrane Transporters and Drug Response......Page 84 6. Drug Metabolism......Page 104 7. Pharmacogenetics......Page 120 Section II: Neuropharmacology......Page 132 8. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems......Page 134 9. Muscarinic Receptor Agonists and Antagonists......Page 168 10. Anticholinesterase Agents......Page 182 11. Nicotine and Agents Acting at the Neuromuscular Junction and Autonomic Ganglia......Page 196 12. Adrenergic Agonists and Antagonists......Page 210 13. 5-Hydroxytryptamine (Serotonin) and Dopamine......Page 244 14. Neurotransmission in the Central Nervous System......Page 262 15. Drug Therapy of Depression and Anxiety Disorders......Page 286 16. Pharmacotherapy of Psychosis and Mania......Page 298 17. Pharmacotherapy of the Epilepsies......Page 322 18. Treatment of Central Nervous System Degenerative Disorders......Page 346 19. Hypnotics and Sedatives......Page 358 20. Opioids, Analgesia, and Pain Management......Page 374 21. General Anesthetics and Therapeutic Gases......Page 406 22. Local Anesthetics......Page 424 23. Ethanol......Page 440 24. Drug Use Disorders and Addiction......Page 452 Section III: Modulation of Pulmonary, Renal, and Cardiovascular Function......Page 462 25. Drugs Affecting Renal Excretory Function......Page 464 26. Renin and Angiotensin......Page 490 27. Treatment of Ischemic Heart Disease......Page 508 28. Treatment of Hypertension......Page 526 29. Therapy of Heart Failure......Page 546 30. Antiarrhythmic Drugs......Page 566 31. Treatment of Pulmonary Arterial Hypertension......Page 592 32. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs......Page 604 33. Drug Therapy for Dyslipidemias......Page 624 Section IV: Inflammation, Immunomodulation, and Hematopoiesis......Page 638 34. Introduction to Immunity and Inflammation......Page 640 35. Immunosuppressants and Tolerogens......Page 656 36. Immune Globulins and Vaccines......Page 674 37. Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor......Page 692 38. Pharmacotherapy of Inflammation, Fever, Pain, and Gout......Page 704 39. Histamine, Bradykinin, and Their Antagonists......Page 730 40. Pulmonary Pharmacology......Page 746 41. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins......Page 770 Section V: Hormones and Hormone Antagonists......Page 788 42. Introduction to Endocrinology: The Hypothalamic-Pituitary Axis......Page 790 43. Thyroid and Antithyroid Drugs......Page 806 44. Estrogens, Progestins, and the Female Reproductive Tract......Page 822 45. Androgens and the Male Reproductive Tract......Page 852 46. Adrenocorticotropic Hormone, Adrenal Steroids, and the Adrenal Cortex......Page 864 47. Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia......Page 882 48. Agents Affecting Mineral Ion Homeostasis and Bone Turnover......Page 906 Section VI: Gastrointestinal Pharmacology......Page 926 49. Pharmacotherapy for Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease......Page 928 50. Gastrointestinal Motility and Water Flux, Emesis, and Biliary and Pancreatic Disease......Page 940 51. Pharmacotherapy of Inflammatory Bowel Disease......Page 964 Section VII: Chemotherapy of Infectious Diseases......Page 974 52. General Principles of Antimicrobial Therapy......Page 976 53. Chemotherapy of Malaria......Page 988 54. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections......Page 1006 55. Chemotherapy of Helminth Infections......Page 1020 56. Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones,and Agents for Urinary Tract Infections......Page 1030 57. Penicillins, Cephalosporins, and Other β-Lactam Antibiotics......Page 1042 58. Aminoglycosides......Page 1058 59. Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents......Page 1068 60. Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosy......Page 1086 61. Antifungal Agents......Page 1106 62. Antiviral Agents (Nonretroviral)......Page 1124 63. Treatment of Viral Hepatitis (HBV/HCV)......Page 1138 64. Antiretroviral Agents and Treatment of HIV Infection......Page 1156 Section VIII: Pharmacotherapy of Neoplastic Disease......Page 1178 65. General Principles in the Pharmacotherapy of Cancer......Page 1180 66. Cytotoxic Drugs......Page 1186 67. Pathway-Targeted Therapies: Monoclonal Antibodies, Protein Kinase Inhibitors, and Various Small Molecules......Page 1222 68. Hormones and Related Agents in the Therapy of Cancer......Page 1256 Section IX: Special Systems Pharmacology......Page 1268 69. Ocular Pharmacology......Page 1270 70. Dermatological Pharmacology......Page 1290 71. Environmental Toxicology: Carcinogensand Heavy Metals......Page 1316 I. Principles of Prescription Order Writing and Patient Compliance......Page 1336 II. Design and Optimization of Dosage Regimens: Pharmacokinetic Data......Page 1344 A......Page 1398 B......Page 1402 C......Page 1404 D......Page 1408 E......Page 1411 F......Page 1413 G......Page 1414 H......Page 1415 I......Page 1417 K......Page 1419 L......Page 1420 M......Page 1421 N......Page 1424 O......Page 1426 P......Page 1427 R......Page 1431 S......Page 1432 T......Page 1434 V......Page 1437 Z......Page 1438 The gold-standard of pharmacology texts – completely updated to reflect the latest research and developments A Doody's Core Title for 2020! Goodman & Gilman's: The Pharmacological Basis of Therapeutics, Thirteenth Edition represents the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. Goodman & Gilman's careful balance of basic science and clinical application has guided thousands of practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing, and treating disease. The Thirteenth Edition includes more than 500 color illustrations, with many new figures emphasizing mechanisms of drug action. More than 30 new contributors have added to this edition, while the focus on basic principles is undiminished. This edition is enhanced by timely new content: •NEW chapters including Treatment of Pulmonary Arterial Hypertension, Immunity and Inflammation, Immunoglobulins and Vaccines, and Treatment of Viral Hepatitis •Expanded coverage of cardiovascular disease, with separate chapters on myocardial ischemia, hypertension, and heart failure •Increased emphasis on cellular signaling pathways involved in drug action •Summary tables at the end of each chapter that organize drugs discussed in that chapter into relevant categories and detail therapeutic usage, clinical pharmacology, and tips •Chapter Content Outlines at the beginning of each chapter •Abbreviation boxes in every chapter to easily identify the abbreviations appearing in that chapter More than a textbook, Goodman & Gilman's is a working template for the effective and rational prescribing of drugs in daily practice. The gold-standard of pharmacology texts - completely updated to reflect the latest research and developments A Doody's Core Title for 2021! Goodman & Gilman's: The Pharmacological Basis of Therapeutics , Thirteenth Edition represents the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. Goodman & Gilman's careful balance of basic science and clinical application has guided thousands of practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing, and treating disease. The Thirteenth Edition includes more than 500 color illustrations, with many new figures emphasizing mechanisms of drug action. More than 30 new contributors have added to this edition, while the focus on basic principles is undiminished. This edition is enhanced by timely new content: NEW chapters including Treatment of Pulmonary Arterial Hypertension, Immunity and Inflammation, Immunoglobulins and Vaccines, and Treatment of Viral Hepatitis Expanded coverage of cardiovascular disease, with separate chapters on myocardial ischemia, hypertension, and heart failure Increased emphasis on cellular signaling pathways involved in drug action Summary tables at the end of each chapter that organize drugs discussed in that chapter into relevant categories and detail therapeutic usage, clinical pharmacology, and tips Chapter Content Outlines at the beginning of each chapter Abbreviation boxes in every chapter to easily identify the abbreviations appearing in that chapter More than a textbook, Goodman & Gilman's is a working template for the effective and rational prescribing of drugs in daily practice. Goodman & Gilman's: The Pharmacological Basis Of Therapeutics, Thirteenth Edition Represents The Pinnacle Of Authority And Accuracy In Describing The Actions And Uses Of Therapeutic Agents In Relation To Physiology And Pathophysiology. Goodman & Gilman's Careful Balance Of Basic Science And Clinical Application Has Guided Thousands Of Practitioners And Students To A Clear Understanding Of The Drugs Essential To Preventing, Diagnosing, And Treating Disease. Enhanced By A Full-colour Presentation And Updated To Reflect All Critical New Developments In Drug Action And Drug-disease Interaction, The Thirteenth Edition Includes More Than 440 Color Illustrations Depicting Key Principles And Actions Of Specific Pathways And Therapeutic Agents. This Edition Also Includes New Chapters On Hypertension Therapy, Myocardial Ischemia Therapy, Treatment Of Pulmonary Arterial Hypertension, Immunostimulants And Vaccines, And Treatment Of Viral Hepatitis, Along With Appendices On Prescription Order Writing, Patient Compliance, And Pharmacokinetics. -- Provided By Publisher. Section I: General Principles -- Section Ii: Neuropharmacology -- Section Iii: Modulation Of Pulmonary, Renal, And Cardiovascular Function -- Section Iv: Inflammation, Immunomodulation, And Hematopoiesis -- Section V: Hormones And Hormone Antagonists -- Section Vi: Gastrointestinal Pharmacology -- Section Vii: Chemotherapy Of Infectious Diseases -- Section Viii: Pharmacotherapy Of Neoplastic Disease -- Section Ix: Special Systems Pharmacology. Editor, Laurence L. Brunton ; Associate Editors, Björn C. Knollmann, Randa Hilal-dandan. Includes Bibliographical References And Index.