Mapping the Progress of Alzheimer’s and Parkinson’s Disease (Advances in Behavioral Biology, 51)

This book is the proceedings of the highly successful 5 th International Conference on Progress in Alzheimer's Disease and Parkinson's Disease which took place from March 31 st to April 5 th , 2001, in Kyoto, Japan. This international conference was organized as a joint Congress with the 9 th International Catecholamine Symposium, and included a total of 1258 clinicians and researchers from 38 countries throughout the world. This meeting was an extremely good opportunity for investigators and clinicians to meet and discuss with people who were working in somewhat different but closely related fields, and to exchange their scientific knowledge and experiences. 1h The 5 International Conference on the Progress in Alzheimer's Disease and Parkinson's 51 1 Disease took place from March 31 to April 5 \ 2001 in Kroto, Japan. This international 1 conference was organized as a joint Congress with the 9 International Catecholamine Symposium. A total of 1258 clinicians and researchers participated in this joint congress 1h from 38 countries in the world. This book represents the proceedings of the 5 Conference on Alzheimer's and Parkinson's disease. The International Conference on the Progress in Alzheimer's and Parkinson's disease was first launched by Professor Abraham Fisher of Israel and Professor Israel Hanin of USA. The first conference was held in Eilat, Israel in 1985. The second conference was organized in Kyoto, Japan in 1989; the third one in Chicago, USA, in 1993, and the fourth one in Eilat, Israel in 1997. The International Catecholamine Symposium (ICS) is an international meeting devoted to the development of basic as well as clinical research on catecholamines. The first Catecholamine Symposium was held in Bethesda, USA in 1958. Since then this symposium has occurred every 5 years. Professor Toshiharu Nagatsu was appointed as 1h the president of the 9 International Catecholamine Symposium, which was to be held in 200 I also in Japan. Therefore, we decided to organize a joint congress of the two meetings, because there is much overlap in research between Alzheimer's disease, Parkinson's disease, and catecholamines. We thank Professor Nagatsu very much for agreeing to organizing this joint congress. Preliminaries......Page 1 SCIENTIFIC ADVISORY BOARD......Page 6 ACKNOWLEDGEMENTS......Page 10 PREFACE......Page 12 CONTENTS......Page 14 ETIOLOGY AND PATHOGENESIS OF ALZHEIMER’S DISEASE......Page 24 FAMILIAL ALZHEIMER’S DISEASE AND BIOLOGY OF PRESENILINS......Page 88 ANIMAL MODELS OF ALZHEIMER’S DISEASE......Page 140 GLYCOSAMINOGLYCANS (GAGs) IN ALZHEIMER’S DISEASE......Page 168 PROGRESS IN THE TREATMENT OF ALZHEIMER’S DISEASE......Page 210 NOVEL DRUG TREATMENT OF ALZHEIMER’S DISEASE......Page 228 ETIOLOGY AND PATHOGENESIS......Page 262 FAMILIAL PARKINSON’S DISEASE......Page 304 CLINICAL TOPICS IN PARKINSON’S DISEASE......Page 328 PROGRESS IN THE TREATMENT OF PARKINSON’S DISEASE......Page 384 DOPAMINE AGONISTS......Page 402 SURGICAL TREATMENT OF PARKINSON’S DISEASE......Page 452 NEW TREATMENT ON THE HORIZON IN PARKINSON’S DISEASE......Page 470 DEMENTIA WITH LEWY BODIES......Page 496 INDEX......Page 572 Annotation This book is the proceedings of the highly successful5 International Conference on Progress in Alzheimer's Diseaseand Parkinson's Disease which took place from March 31 toApril 5, 2001, in Kyoto, Japan. This international conferencewas organized as a joint Congress with the 9 InternationalCatecholamine Symposium, and included a total of 1258 clinicians andresearchers from 38 countries throughout the world. This meeting wasan extremely good opportunity for investigators and clinicians to meetand discuss with people who were working in somewhat different butclosely related fields, and to exchange their scientific knowledge andexperiences Here, we recently summarize recent work from our laboratories on two interrelated aspects of the role of amyloid -proteins (A ) as the initiator of Alzheimer's disease (AD): its production and its degradation.