Mao - The Mother Of All Amine Oxidases (journal Of Neural Transmission. Supplementa)

Monoamine oxidase (MAO) is linked to psychiatric and neurological disorders, because inhibitors of the enzyme are used clinically for treatment of affective disorders and Parkinson’s disease. One of the interesting new aspects of MAO is the occurrence in the human population of deletions of genes coding for one or the other enzyme subtype (A or B). This leads to the possibility of a genetic basis for psychiatric disorders based on MAO. Subjects with deletions of type A or B, and combined deletions, have been described. In the first group of 6 papers in this book, the occurrence and characterization of these phenotypes, as well as the structure of MAO genes, is explored. Advances in the biochemistry of MAO subtypes and their physiological function and localization in brain and periphery is included. Other sections of the book deal with the neuroprotective action of MAO inhibitors and their pharmacology, especially the pharmacology of new MAO-B inhibitors. Front Matter....Pages I-XIX Determination of regions important for Monoamine Oxidase (MAO) A and B substrate and inhibitor selectivities....Pages 1-8 Monoamine oxidase A deficiency: Biogenic amine metabolites in random urine samples....Pages 9-15 Relationship between monoamine oxidase (MAO) A specific activity and proportion of human skin fibroblasts which express the enzyme in culture....Pages 17-27 Are MAO-A deficiency states in the general population and in putative high-risk populations highly uncommon?....Pages 29-38 Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline)....Pages 39-48 Experience with tranylcypromine in early Parkinson’s disease....Pages 49-61 Deprenyl monotherapy improves visuo-motor control in early parkinsonism....Pages 63-69 Endogenous monoamine oxidase A inhibitory activity (tribulin), measured in saliva, is related to cardiovascular reactivity in normal individuals....Pages 71-77 MAO inhibitory side effects of neuroleptics and platelet serotonin content in schizophrenic patients....Pages 79-85 Modulation of glutamate neurotoxicity in the transformed cell culture by monoamine oxidase inhibitors, clorgyline and deprenyl....Pages 87-91 A cell culture model of cerebral ischemia as a convenient system to screen for neuroprotective drugs....Pages 93-98 Neuroprotection by selegiline and other MAO inhibitors....Pages 99-107 The neuroprotective and neuronal rescue effects of (—)-deprenyl....Pages 109-123 Oxidation of N-methyl(R)salsolinol: involvement to neurotoxicity and neuroprotection by endogenous catechol isoquinolines....Pages 125-138 Substrate regulation of monoamine oxidases....Pages 139-147 Monoamine oxidases and related amine oxidases as phase I enzymes in the metabolism of xenobiotics....Pages 149-171 Monoamine oxidases: from brain maps to physiology and transgenics to pathophysiology....Pages 173-187 Structure-function relationships of mitochondrial monoamine oxidase A and B: chimaeric enzymes and site-directed mutagenesis studies....Pages 189-200 Deamination of methylamine and angiopathy; toxicity of formaldehyde, oxidative stress and relevance to protein glycoxidation in diabetes....Pages 201-216 Monoamine oxidase activities in human cystic and colonic arteries — influence of age....Pages 217-223 Influence of maturation and ageing on the biotransformation of noradrenaline in the rat....Pages 225-232 The oxidation of dopamine and epinine by the two forms of monoamine oxidase from rat liver....Pages 233-238 Properties and functions of tissue-bound semicarbazide-sensitive amine oxidases in isolated cell preparations and cell cultures....Pages 239-250 Studies on the time-dependent activation of microsomal semicarbazide-sensitive amine oxidase....Pages 251-257 Studies on the behaviour of semicarbazide-sensitive amine oxidase in Sprague-Dawley rats treated with the monoamine oxidase inhibitor tranylcypromine....Pages 259-264 Semicarbazide-sensitive amine oxidase in pig heart....Pages 265-270 Chronic TVP-1012 (rasagiline) dose — activity response of monoamine oxidases A and B in the brain of the common marmoset....Pages 271-278 Increased striatal dopamine production from L-DOPA following selective inhibition of monoamine oxidase B by R(+)-N-propargyl-1-aminoindan (rasagiline) in the monkey....Pages 279-285 Effects of N-propargyl-1-(R)aminoindan (rasagiline) in models of motor and cognition disorders....Pages 287-300 (R)(+)-N-Propargyl-1-aminoindan (rasagiline) and derivatives: highly selective and potent inhibitors of monoamine oxidase B....Pages 301-305 Function of endogenous monoamine oxidase inhibitors (tribulin)....Pages 307-313 Long term administration of (—)-deprenyl increases mortality in male Wistar rats....Pages 315-320 Selegiline as immunostimulant — a novel mechanism of action?....Pages 321-328 Clorgyline effect on pineal melatonin biosynthesis in rats with lesioned suprachiasmatic nuclei....Pages 329-332 The effect of MAO-A inhibition and cold-immobilization stress on N-acetylserotonin and melatonin in SHR and WKY rats....Pages 333-336 The influence of the antidepressant pirlindole and its dehydro-derivative on the activity of monoamine oxidase A and GABA A receptor binding....Pages 337-342 “In vitro” effect of some 5-hydroxy-indolalkylamine derivatives on monoamine uptake system....Pages 343-349 N-Alkyloxycarbonyl derivatives of ethylene diamine as monoamine oxidase inhibitors....Pages 351-355 Back Matter....Pages 357-363 One of the aspects of Monoamine oxidase (MAO) is the occurrence in the human population of deletions of genes coding for one or the other enzyme subtype (A or B). This book describes subjects with deletions of type A or B, and combined deletions. It explores the occurrence and characterization of these phenotypes, and the structure of MAO genes.