Manual of Childhood Infections : The Blue Book

Now in its third edition, and endorsed by both the Royal College of Paediatrics and Child Health and the European Society of Pediatric Infectious Diseases, the Manual of Childhood Infections (known by its readers as The Blue Book ) is a simple-to-use, evidence-based, and practical handbook on how to recognise, investigate and manage both common and rare infectious diseases in children and babies. The handbook is divided into two sections, the first of which is syndrome-based and covers all the key diagnosis and management features of common childhood infections, such as sepsis, meningitis, and pneumonia. The second section lists specific organisms, and provides all the key points in the epidemiology, clinical features, and management for all the key infections. Each chapter includes key references for further reading and suggestions for future research. Packed with helpful tips and practical guidance, including lists of alternative diagnoses and useful tables, the handbook also features a neonatal and paediatric formulary of around 100 of the commonest used antimicrobials based on the BNF for Children, but presented in a simple easy-to-use weight based dosing regimen. Common side effects and cautions are also included. The book is aimed at both junior trainees looking after ill children and more senior colleagues who want to check their management plans, and is written for both a UK and European audience, reflecting the range of clinical practice across Europe, while being clear where the evidence base is strongest. Cover 1 Contents 10 Section editors 15 Contributors 16 Abbreviations and symbols 25 Section 1 Clinical syndromes 32 1 Antibiotics and resistance 34 2 Antifungal drugs 41 3 Antiparasitics 51 4 Antivirals 56 5 Bone and joint infections 69 6 Cardiac infections: endocarditis 75 7 Cardiac infections: myocarditis and pericarditis 85 8 Central venous catheter infections 99 9 Chronic fatigue syndrome 104 10 Congenital infections 108 11 Conjunctivitis 121 12 Diarrhoea and vomiting 128 13 Emerging and re-emerging infections 133 14 Encephalitis 138 15 Enlarged lymph nodes 147 16 Haemolytic-uraemic syndrome 162 17 Healthcare-associated infections 168 18 Acute hepatitis 179 19 Human immunodeficiency virus infection 184 20 Immunocompromised children with infection 194 21 Infection control in community settings 203 22 Intra-abdominal infections 209 23 Invasive fungal infection 224 24 Investigating the child with possible immunodeficiency 235 25 Kawasaki disease 245 26 Laboratory diagnosis of infection 251 27 Lower respiratory tract infection 261 28 Mastoiditis, quinsy, and brain abscess 271 29 Meningitis 278 30 Neonatal infection 293 31 Ocular infections 301 32 Periodic fever syndromes 313 33 Pyrexia of unknown origin 318 34 Rash: making a diagnosis 323 35 Refugees and internationally adopted children 334 36 Sepsis syndrome 339 37 Sexually transmitted infections 351 38 Skin and soft tissue infections 358 39 Toxic shock syndrome 365 40 Trauma, bites, and burns 375 41 Travelling abroad with children 381 42 The unwell child returning from abroad 388 43 Urinary tract infection 395 44 Upper respiratory tract infections 404 45 Zoonoses 414 Section 2 Specific infections 422 46 Adenovirus 425 47 Amoebiasis 432 48 Anaerobic infections 438 49 Arboviruses 447 50 Ascariasis 456 51 Aspergillosis 465 52 Botulism 479 53 Brucellosis 483 54 Campylobacter 487 55 Candidiasis 491 56 Cat scratch disease 495 57 Chicken pox—varicella zoster 498 58 Chlamydia 506 59 Cholera 514 60 Clostridium difficile infection 518 61 Cryptosporidiosis 527 62 Cytomegalovirus 530 63 Diphtheria 536 64 Enteroviruses and parechoviruses 539 65 Epstein–Barr virus 548 66 Escherichia coli diarrhoea 552 67 Giardiasis 554 68 Gonococcal infection 558 69 Gram-negative bacteria 562 70 Haemophilus influenzae 568 71 Hand, foot, and mouth disease 573 72 Head lice (pediculosis) 575 73 Helicobacter pylori 579 74 Helminthiases 584 75 Hepatitis B 595 76 Hepatitis C 602 77 Herpes simplex virus 1 and 2 607 78 Human herpesviruses 6 and 7 614 79 Human papillomavirus 618 80 Influenza and parainfluenza 626 81 Legionella 631 82 Leishmaniasis 634 83 Listeriosis 640 84 Lyme disease 644 85 Malaria 647 86 Measles 655 87 Meningococcal disease 659 88 Molluscum contagiosum and other poxviruses 668 89 Mumps 671 90 Mycoplasma 675 91 Non-tuberculous mycobacterial infection 680 92 Norovirus 686 93 Parvovirus 690 94 Pertussis 695 95 Plague 701 96 Pneumocystis pneumonia (PcP) 705 97 Polio 709 98 Rabies 714 99 Respiratory syncytial virus 718 100 Rotavirus 723 101 Rubella 727 102 Scabies 732 103 Schistosomiasis 736 104 Shigellosis 741 105 Staphylococcal infections including MRSA 744 106 Streptococcal infections 752 107 Syphilis 761 108 Tetanus 766 109 Threadworm 769 110 Tinea 772 111 Toxocariasis 778 112 Toxoplasmosis 780 113 Tuberculosis 784 114 Typhoid and paratyphoid—enteric fever 790 115 Typhus 795 116 Viral haemorrhagic fevers 802 117 Yellow fever 809 118 Yersiniosis 814 Appendices 817 Appendix 1 The contribution of infectious diseases to neonatal and childhood deaths in England and Wales 817 Appendix 2 Guidance on infection control in school and other childcare settings 823 Appendix 3 Immunization of the normal and immunocompromised child 828 Appendix 4 Notification and surveillance of infectious diseases 834 Appendix 5 Blue Book Formulary 841 Index 894 A 894 B 896 C 896 D 898 E 898 F 899 G 900 H 900 I 902 J 903 K 903 L 903 M 904 N 905 O 905 P 906 Q 907 R 907 S 908 T 910 U 911 V 911 W 912 X 912 Y 912 Z 912 Endorsed by The Royal College of Paediatrics and Child Health, providing the standard of care within NHS practice, and the European Society of Pediatric Infectious Diseases Contains contributions from over 150 international experts writing on specialised topics Features a neonatal and paediatric formulary of around 100 of the most commonly used antimicrobials based on the BNF for Children, presented in an easy-to-use weight based dosing regimen and including common side effects and cautions New to this edition Many new chapters extend the range of the book to include all common and rarer childhood infections, while an enhanced european and global focus reflects the changing world of international travel and imported infections Now in its third edition, and endorsed by both the Royal College of Paediatrics and Child Health and the European Society of Pediatric Infectious Diseases, the Manual of Childhood Infections (known by its readers as The Blue Book) is a simple-to-use, evidence-based, and practical handbook on how to recognise, investigate and manage both common and rare infectious diseases in children and babies. The handbook is divided into two sections, the first of which is syndrome-based and covers all the key diagnosis and management features of common childhood infections, such as sepsis, meningitis, and pneumonia. The second section lists specific organisms, and provides all the key points in the epidemiology, clinical features, and management for all the key infections. Each chapter includes key references for further reading and suggestions for future research. Packed with helpful tips and practical guidance, including lists of alternative diagnoses and useful tables, the handbook also features a neonatal and paediatric formulary of around 100 of the commonest used antimicrobials based on the BNF for Children, but presented in a simple easy-to-use weight based dosing regimen Common side effects and cautions are also included. The book is aimed at both junior trainees looking after ill children and more senior colleagues who want to check their management plans, and is written for both a UK and European audience, reflecting the range of clinical practice across Europe, while being clear where the evidence base is strongest. Readership: Trainee and consultant paediatricians in the UK and Europe, and beyond This manual gives information on the causative organisms, epidemiology and clinical features of all important childhood infections. It includes guidance on the clinical management of the infections and on steps to be taken to prevent future cases